%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 96.88999939 23.67700005 Tm 0 g [(TKT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.70599365 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 141.70599365 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 318.41000366 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TKT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.93800354 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.93800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TKT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.06199646 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.26399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.63800049 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61799622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.99200439 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.46600342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transke)1(to)-1(lase;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.46199799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.83599854 12.82499981 Tm [(TK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.21699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.59100342 12.82499981 Tm [(TKT1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.41099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.78500366 12.82499981 Tm [(HEL)-1(10)1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.83399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TKT)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 271.32800293 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansk)-1(eto)1(lase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.19900131 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.03899956 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.53899956 11.72200012 Tm [(TKT1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.01499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.51499939 11.72200012 Tm [(HEL1)-1(07)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.87599945 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P29)-1(40)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(09)-1(97)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 138.92500305 16.35000038 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 138.17500305 0.75 l 138.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 139.17500305 -0.25 l 139.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 138.92500305 78.75 l h f* Q q 1 0 0 1 138.55000305 0 cm -0.625 -0.25 m 288.625 -0.25 l 288.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(th)1(iamine)-1(-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.33399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.83399963 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.21499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.71499634 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.81199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.31201172 11.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.35900879 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.13500023 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.63500023 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.57600021 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.07600021 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.07699966 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.57699966 27.3220005 Tm [(channe)-1(ling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.89700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.39700317 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.23899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.73899841 27.3220005 Tm [(exc)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.35899353 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.85899353 27.3220005 Tm [(suga)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.23899841 27.3220005 Tm [(ph)1(osph)1(ates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.30599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80599976 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.8809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.3809967 27.3220005 Tm [(glyc)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.88599968 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.38599968 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.32699966 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.82699966 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.82799911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.32799911 42.92200089 Tm [(pentos)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.0759964 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.5759964 42.92200089 Tm [(ph)1(osph)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.477005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.977005 42.92200089 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.10499573 42.92200089 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.98599243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.48599243 42.92200089 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.56698608 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.42200089 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.99199677 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 58.52199936 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.83399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.33399963 58.52199936 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.70599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.20599365 58.52199936 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.36599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86599731 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.21299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.71299744 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.22000122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.72000122 58.52199936 Tm [(ob)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(erve)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.12999916 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.62999916 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.90800095 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.40800095 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.86399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.36399841 74.12200165 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.04599762 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 0.75 m 138.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 17.10000038 m 138.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 33.45000076 m 138.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 49.80000305 m 138.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 66.15000153 m 138.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 82.5 m 138.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 98.84999847 m 138.55000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.55000305 115.19999695 m 138.55000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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