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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.54299927 23.67700005 Tm 0 g [(THOP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.05200195 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.05200195 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 332.75601196 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(THOP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.35700226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.60700226 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.60699463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(THOP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.35700226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73100281 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.93299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.30700684 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.66099548 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.13499451 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(thi)-1(me)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.57299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.9469986 12.82499981 Tm [(ol)-1(igop)-1(e)1(p)-1(tid)-1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.84399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.21800232 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.34899902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.7230072 12.82499981 Tm [(TOP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.02600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.3999939 12.82499981 Tm [(MP7)1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.6289978 12.82499981 Tm [(EP24.15;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.92800903 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.30200195 12.82499981 Tm [(MEPD_HUMA)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.6289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(490-6)1(89)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(THOP1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 340.96899414 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(th)1(ime)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.18199921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.68199921 11.72200012 Tm [(oligo)1(peptid)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.02700043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.52700043 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TOP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.16699982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.66699982 11.72200012 Tm [(MP78)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.68899918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18899918 11.72200012 Tm [(EP24.1)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.08799744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.58799744 11.72200012 Tm [(MEPD)1(_)-1(HUMA)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.84899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P52)-1(88)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(13)-1(87)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 110.17500305 16.35000038 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 109.42500305 0.75 l 109.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 110.42500305 -0.25 l 110.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.17500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 110.17500305 78.75 l h f* Q q 1 0 0 1 109.80000305 0 cm -0.625 -0.25 m 317.375 -0.25 l 317.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(ki)-1(ninase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.66999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.16999817 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.39199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.89199829 11.72200012 Tm [(uses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.87600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.37600708 11.72200012 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.25500488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.75500488 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.89599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.39599609 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.3710022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cofacto)1(r.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.52099991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.02099991 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.82799911 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.32799911 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.83499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.33499908 27.3220005 Tm [(oligo)1(peptid)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.67999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.17999268 27.3220005 Tm [(cl)-1(eaves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.16600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.66600037 27.3220005 Tm [(cy)-1(t)1(osolic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.20799255 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.70799255 27.3220005 Tm [(pept)1(ides,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.2539978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.7539978 27.3220005 Tm [(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.59799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.09799957 42.92200089 Tm [(th)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.5320015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.0320015 42.92200089 Tm [(unavailab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.81099701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.31099701 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58899689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.08899689 42.92200089 Tm [(disp)1(lay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.28799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.78799438 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.05599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.55599976 42.92200089 Tm [(antig)1(e)-1(n-)1(prese)-1(nt)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.28700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.7869873 42.92200089 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.5289917 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.0289917 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.29098511 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.06399918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.56399918 58.52199936 Tm [(cl)-1(eaves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55000305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.05000305 58.52199936 Tm [(ne)-1(uro)1(peptid)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.78599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.28599548 58.52199936 Tm [(under)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.67799377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.17799377 58.52199936 Tm [(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.73399353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.23399353 58.52199936 Tm [(aa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.18299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.68299866 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.62399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.12399292 58.52199936 Tm [(len)-1(g)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.82299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.32299805 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.6000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.1000061 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.13400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(degra)1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.89500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.39500046 74.12200165 Tm [(beta)1(-amyloid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.91100311 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.41100311 74.12200165 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.52200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.02200317 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.32899475 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.82899475 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.90400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.40400696 74.12200165 Tm [(amyloido)1(gen)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.88299561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.38299561 74.12200165 Tm [(pept)1(ides.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.9289856 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 0.75 m 109.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 17.10000038 m 109.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 33.45000076 m 109.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 49.80000305 m 109.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 66.15000153 m 109.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 82.5 m 109.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 98.84999847 m 109.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.80000305 115.19999695 m 109.80000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm
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