%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 107 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 77.74199677 23.67700005 Tm 0 g [(THAP12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.85400391 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 160.85400391 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 337.55801392 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(THAP1)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.80200195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.05200195 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.05200195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(THAP1)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.80200195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.1760025 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.37800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.7519989 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.73199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.10600281 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.58000183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(THAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.15799713 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.53199768 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.92900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3030014 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.13800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.51199341 12.82499981 Tm [(12;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.96499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.33900452 12.82499981 Tm [(DAP)1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.42999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.80400085 12.82499981 Tm [(THAP0)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.09399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.46800232 12.82499981 Tm [(PRK)1(RIR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.90600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.27999878 12.82499981 Tm [(P5)1(2rIP)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.5329895 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(612-7)1(61)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(THAP1)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 344.7789917 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TH)-1(A)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.95899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.45899963 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.2859993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.78600311 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.53299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.03299713 11.72200012 Tm [(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.58899689 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DA)1(P4)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.13899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.63899994 11.72200012 Tm [(TH)-1(A)1(P0)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.04199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.54199982 11.72200012 Tm [(PRK)1(RIR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.19999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.69999695 11.72200012 Tm [(P52)-1(rI)1(PK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06300354 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O43)-1(42)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(21)-1(99)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 162.375 31.95000076 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(AG)1(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.97400093 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 162.375 16.35000038 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 161.625 0.75 l 161.625 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 162.625 -0.25 l 162.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 162.375 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 162.375 63.15000153 l h f* Q q 1 0 0 1 162 0 cm -0.625 -0.25 m 265.17498779 -0.25 l 265.17498779 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Up)1(stream)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93700027 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.43700027 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.16400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66400146 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.5059967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.0059967 11.72200012 Tm [(interferon-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.28700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.78700256 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.9129982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4129982 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.50099945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.00099945 27.3220005 Tm [(R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.87599945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.37599945 27.3220005 Tm [(\(PKR)1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.64900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.14900208 27.3220005 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.18099976 27.3220005 Tm [(block)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.45899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.95899963 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.96000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.46000671 27.3220005 Tm [(PKR)1(-inhibito)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.7440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.2440033 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(unc)-1(t)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.62099838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.12099838 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.96300125 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.46300125 42.92200089 Tm [(DNA)1(JC3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.99700165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.49700165 42.92200089 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.19799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.69799805 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.63900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.13900757 42.92200089 Tm [(resto)1(ratio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.34899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.84899902 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.69099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.19099426 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.27900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.77900696 42.92200089 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ivity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.63100052 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.13100052 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.40800095 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.90800095 58.52199936 Tm [(supp)1(re)-1(ss)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.65399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.15399933 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.9960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.4960022 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.40600586 58.52199936 Tm [(gr)1(owt)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.48800659 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 0.75 m 162 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 17.10000038 m 162 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 33.45000076 m 162 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 49.80000305 m 162 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 66.15000153 m 162 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 98.1000061 m 162 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 114.45000458 m 162 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162 130.80000305 m 162 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57501221 m 426.92498779 193.57501221 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>