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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.15299988 23.67700005 Tm 0 g [(TGM5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.44299316 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.44299316 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.14700317 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TGM5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.04000092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.29000092 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.28999329 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TGM5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.04000092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.41400146 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.61599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.98999786 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.97000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.34399414 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.81799316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transglu)-1(tam)1(i)-1(nase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29400635 12.82499981 Tm [(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.42500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.79899597 12.82499981 Tm [(TGX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.79899597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.17300415 12.82499981 Tm [(PSS)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.37800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.7519989 12.82499981 Tm [(TGM6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.60099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.9750061 12.82499981 Tm [(TGMX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.95300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.32699585 12.82499981 Tm [(TGASE)-1(5)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.22601318 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.6000061 12.82499981 Tm [(TGASE)-1(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.81799316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(TGM5)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 280.20098877 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansgluta)1(m)-1(inas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.1230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.6230011 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90100098 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TGX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.8239994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.3239994 11.72200012 Tm [(PSS2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.6629982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.1629982 11.72200012 Tm [(TGM6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.25299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.75299835 11.72200012 Tm [(TGMX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.37000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.87000275 11.72200012 Tm [(TGASE)1(5)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.64100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.14100647 11.72200012 Tm [(TGASE)1(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.272995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O43)-1(54)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(22)-1(85)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 160.125 31.95000076 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.125 16.35000038 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 159.375 0.75 l 159.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 160.375 -0.25 l 160.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.125 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 160.125 94.34999847 l h f* Q q 1 0 0 1 159.75 0 cm -0.625 -0.25 m 267.42498779 -0.25 l 267.42498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(tr)1(ansgluta)1(m)-1(inas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.3999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.8999939 11.72200012 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.15299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.65299988 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.45999908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.95999908 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.46700287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.96700287 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.27400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.77400208 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.44599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.94599915 27.3220005 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.647995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.147995 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.99000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.49000549 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(cross-)1(l)-1(inks)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.29899979 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.79899979 42.92200089 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.8710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.3710022 42.92200089 Tm [(gluta)1(min)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.8769989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.3769989 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.65400696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.15400696 42.92200089 Tm [(lysin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.52600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02600098 42.92200089 Tm [(residues,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.87199402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.37199402 42.92200089 Tm [(of)1(ten)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.21899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.70100021 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.20100021 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.14199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.64199829 58.52199936 Tm [(st)1(abilizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.48400116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.98400116 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.8259964 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.3259964 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.63299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.13299561 58.52199936 Tm [(assemblies.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.95599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.45599365 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.71800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.21800232 58.52199936 Tm [(reacti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.82900047 74.12200165 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.59899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.09899902 74.12200165 Tm [(dependen)-1(t)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.29100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.79100037 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.63999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.13999939 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.08099365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.58099365 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.03700256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.53700256 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05299377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.55299377 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.8999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.3999939 74.12200165 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ee)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75899982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25900078 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.38600159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.88600159 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.28199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.78199768 89.72200012 Tm [(acral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.0759964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.5759964 89.72200012 Tm [(peel)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.63000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.13000488 89.72200012 Tm [(skin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.13699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.63699341 89.72200012 Tm [(syndrome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.73399353 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 0.75 m 159.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 17.10000038 m 159.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 33.45000076 m 159.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 49.80000305 m 159.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 66.15000153 m 159.75 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 98.1000061 m 159.75 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 114.45000458 m 159.75 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.75 130.80000305 m 159.75 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm
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