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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.77100372 23.67700005 Tm 0 g [(TFEB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.82499695 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 146.82499695 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.5289917 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TF)-1(EB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.02999878 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.02999878 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TF)-1(EB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.15399933 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.35600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.73000336 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.71000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.08399963 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.55799866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transcripti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.83799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.21199799 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.60099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.9750061 12.82499981 Tm [(EB;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.6230011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.99699402 12.82499981 Tm [(TC)-1(FEB;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.18499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.55900574 12.82499981 Tm [(BHLHE)-1(35)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.34899902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.7230072 12.82499981 Tm [(ALPHA)1(T)-1(FEB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.03399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(300-4)1(76)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(TF)-1(EB)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 333.61700439 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.58399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08399963 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.20300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.70300293 11.72200012 Tm [(EB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.29799652 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TCFEB)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.72299957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.22299957 11.72200012 Tm [(BH)-1(LH)-1(E)1(3)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.08100128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.58100128 11.72200012 Tm [(ALPHATFEB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86799622 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P19)-1(48)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(32)-1(44)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.375 16.35000038 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.625 0.75 l 130.625 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 131.625 -0.25 l 131.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.375 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 131.375 109.94999695 l h f* Q q 1 0 0 1 131 0 cm -0.625 -0.25 m 296.17498779 -0.25 l 296.17498779 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Transcriptio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.39099884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.89099884 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.01000214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.51000214 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.73200226 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.23200226 11.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.71699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.21699524 11.72200012 Tm [(rec)-1(o)1(gnizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.38999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.88999939 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.66700745 11.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.2789917 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.7789917 11.72200012 Tm [(E-)1(box)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.65200806 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(seque)-1(nce)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.01300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.51300049 27.3220005 Tm [(\(5')-1(-)1(CANNTG-)1(3)-1('\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.98699951 27.3220005 Tm [(Ef)1(fic)-1(ient)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.48399353 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.98399353 27.3220005 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.52600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.02600098 27.3220005 Tm [(requires)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.97601318 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.47601318 27.3220005 Tm [(dime)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(riza)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.24700165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.74700165 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.14300156 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.64300156 42.92200089 Tm [(itself)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.17900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.67900085 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.83699799 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.33699799 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.73300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.23300171 42.92200089 Tm [(anot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.91299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.41299438 42.92200089 Tm [(MiT/)-1(TFE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.49499512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.99499512 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.07699585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.57699585 42.92200089 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.84100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.34100342 42.92200089 Tm [(suc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18300056 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68300056 58.52199936 Tm [(TFE3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.84999847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.34999847 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.50799942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.00799942 58.52199936 Tm [(MITF.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.55400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.05400085 58.52199936 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.24500275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.74500275 58.52199936 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.67199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.17199707 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.56799316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.06799316 58.52199936 Tm [(TFE3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.90100098 58.52199936 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.96099854 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.96200562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.46200562 58.52199936 Tm [(expr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ession)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.10099983 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.60099983 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.44300079 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.94300079 74.12200165 Tm [(CD40)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.99299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.49299622 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.93399811 74.12200165 Tm [(T-ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.72899628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.22899628 74.12200165 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.28500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.78500366 74.12200165 Tm [(playing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.36399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.86399841 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.83900452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.33900452 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.99899292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.49899292 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.44000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94000244 74.12200165 Tm [(T-ce)-1(ll-d)1(e)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(en)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.41500092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.91500092 89.72200012 Tm [(antib)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.1740036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.6740036 89.72200012 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.83699799 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.33699799 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.77799988 89.72200012 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.92900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.42900085 89.72200012 Tm [(CD4+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.25799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.75799561 89.72200012 Tm [(T-ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.38600159 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.88600159 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.16299438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.66299438 89.72200012 Tm [(th)1(y)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(us-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.63100052 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.1309967 105.3219986 Tm [(humora)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.67900085 105.3219986 Tm [(immun)-1(it)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.71000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.21000671 105.3219986 Tm [(Spec)-1(if)1(i)-1(cally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.72399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.22399902 105.3219986 Tm [(rec)-1(o)1(gnizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.39700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.89700317 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.17401123 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.67401123 105.3219986 Tm [(bi)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 0.75 m 131 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 17.10000038 m 131 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 33.45000076 m 131 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 49.80000305 m 131 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 66.15000153 m 131 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 82.5 m 131 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 98.84999847 m 131 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131 115.19999695 m 131 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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