%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 121 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [(TESC)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 49.16699982 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 225.8710022 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -25 61.9640007 Tm [(TE)-1(SC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 -4.33300018 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0.91699982 61.9640007 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.91700745 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TE)-1(SC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.66699982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.04100037 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.24299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.61699677 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.59700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.97099304 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.44500732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tesc)1(al)-1(cin)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.90299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.27700043 12.82499981 Tm [(TS)-1(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.62599945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [(CHP3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.88699341 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 216.83399963 m 416.75 216.83399963 l 416.75 248.03399658 l -1.45000005 248.03399658 l h f* Q q 1 0 0 1 0 216.83399963 cm /P <> BDC q 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 275.97299194 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(15-21)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(TE)-1(SC)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 328.95800781 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0 G 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0 G 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0 G 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0 G 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 g -1.45000005 304.9119873 m 416.75 304.9119873 l 416.75 336.11199951 l -1.45000005 336.11199951 l h f* Q q 1 0 0 1 0 304.9119873 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 336.11199951 m 416.75 336.11199951 l 416.75 367.31201172 l -1.45000005 367.31201172 l h f* Q q 1 0 0 1 0 336.11199951 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.31201172 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.25100708 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tescalc)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.9620018 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TSC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.54100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.04100037 11.72200012 Tm [(CHP3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.80699921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q96)-1(BS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.00899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(BC0)-1(15)-1(22)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 152.17500305 31.95000076 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 152.17500305 16.35000038 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q 1 g 0.375 0.75 m 151.42500305 0.75 l 151.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 152.42500305 -0.25 l 152.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 152.17500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 152.17500305 94.34999847 l h f* Q q 1 0 0 1 151.80000305 0 cm -0.625 -0.25 m 271.625 -0.25 l 271.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Te)-1(scalcin)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.93500137 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.43500137 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.69200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.19200134 11.72200012 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.01100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.51100159 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.65200043 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.15200043 11.72200012 Tm [(TESC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.64100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.14100647 11.72200012 Tm [(TSC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.51499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.01499939 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.17300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.67300415 11.72200012 Tm [(CHP3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.64100647 11.72200012 Tm [(26)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.97399902 11.72200012 Tm [(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.8030014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.3030014 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.61000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.11000061 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.33200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.83200073 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.04699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.54699707 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.92100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.42100525 27.3220005 Tm [(EF-h)1(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.86300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.36300659 27.3220005 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.19000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.69000244 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.96699524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.4670105 27.3220005 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.81999969 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.31999969 42.92200089 Tm [(ab)1(u)-1(nd)1(antly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.9240036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.4240036 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.36499786 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.86499786 42.92200089 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.88999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.38999939 42.92200089 Tm [(heart)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.80200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.30200195 42.92200089 Tm [(tiss)1(u)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.20100403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.70100403 42.92200089 Tm [(Us)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.28399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78399658 42.92200089 Tm [(calc)-1(iu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.43299961 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.93299961 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0739994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.5739994 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.54899979 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.04899979 58.52199936 Tm [(cofacto)1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.56999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.06999969 58.52199936 Tm [(Te)-1(scalcin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.83899689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.33899689 58.52199936 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.18299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.68299866 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.07899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.57899475 58.52199936 Tm [(NHE-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.97599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.47599792 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.75300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.25300598 58.52199936 Tm [(func)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.82900047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40399933 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.90399933 74.12200165 Tm [(couple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.93399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.43399811 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.43499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.93499756 74.12200165 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.88499451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.38499451 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.227005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.727005 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.72799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.22799683 74.12200165 Tm [(ERK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.76499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.26499939 74.12200165 Tm [(casc)-1(a)1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.27000427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.77000427 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.16600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.66600037 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.66699219 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.95399857 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.45399857 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.29600143 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.79600143 89.72200012 Tm [(Et)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.26300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.76300049 89.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.23600006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.73600006 89.72200012 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.17300415 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.67300415 89.72200012 Tm [(megakaryocy)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.77799988 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 0.75 m 151.80000305 16.35000038 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 17.10000038 m 151.80000305 32.70000076 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 33.45000076 m 151.80000305 49.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 49.80000305 m 151.80000305 65.40000153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 66.15000153 m 151.80000305 97.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 98.1000061 m 151.80000305 113.70000458 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 114.45000458 m 151.80000305 130.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.80000305 130.80000305 m 151.80000305 224.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 422.42498779 97.7250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 422.42498779 114.07500458 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 422.42498779 130.42500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>