%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.55599976 23.67700005 Tm 0 g [(TEP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.03900146 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.03900146 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 323.74301147 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TE)-1(P)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.98999786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.23999786 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.24000549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TE)-1(P)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.98999786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.36399841 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.56600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.94000244 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.29400635 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.76800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(telomer)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.3219986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.69599915 12.82499981 Tm [(asso)-1(c)1(i)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.61300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.98699951 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.3690033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.74299622 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.87399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.2480011 12.82499981 Tm [(TP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.29400635 12.82499981 Tm [(TL)-1(P)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.3809967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.75500488 12.82499981 Tm [(p240;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.42098999 12.82499981 Tm [(TROV)-1(E1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.40701294 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.78100586 12.82499981 Tm [(VAULT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 351.4039917 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(2366)1(-2627)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.10299683 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13800049 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.1789856 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.21398926 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.64498901 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.67999268 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.17300415 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.20800781 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.89401245 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.9289856 12.04500008 Tm [(TE)-1(P)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 342.92001343 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(telomerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.79899979 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29899979 11.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.4260025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.9260025 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.23300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.73300171 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.01100159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.11000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.61000061 11.72200012 Tm [(TLP1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.8390007 11.72200012 Tm [(p24)-1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.58699799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.08699799 11.72200012 Tm [(TROVE1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.93499756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.43499756 11.72200012 Tm [(VAU)1(L)-1(T2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.6289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q99)-1(97)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(26)-1(10)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 135.4750061 16.35000038 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 134.7250061 0.75 l 134.7250061 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 135.7250061 -0.25 l 135.7250061 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.4750061 0.75 m 426.17501831 0.75 l 426.17501831 78.75 l 135.4750061 78.75 l h f* Q q 1 0 0 1 135.1000061 0 cm -0.625 -0.25 m 292.07501221 -0.25 l 292.07501221 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.35299683 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.91400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.41400146 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.38899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.88899994 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.92100525 11.72200012 Tm [(ribo)1(n)-1(ucle)-1(o)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.35699463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.85699463 11.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(omp)1(l)-1(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9659996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.4659996 27.3220005 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.00099945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.50099945 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.77899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.27899933 27.3220005 Tm [(telomerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.07800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.57800293 27.3220005 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.05000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.55000305 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.64700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.14700317 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.81900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.31900024 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.32000732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ad)1(dition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.89899826 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.39899826 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.24100113 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.74100113 42.92200089 Tm [(ne)-1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.49900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.99900055 42.92200089 Tm [(telomeres)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.8239975 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3239975 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.59199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.09199524 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.09300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.59300232 42.92200089 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.38800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.88800049 42.92200089 Tm [(en)-1(d)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.63000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.13000488 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.93701172 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.43701172 42.92200089 Tm [(telo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(merase-as)1(soc)-1(ia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.2440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.7440033 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.21700287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.71700287 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.23500061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.73500061 58.52199936 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.81199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.31199646 58.52199936 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.022995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.522995 58.52199936 Tm [(ci)-1(liat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.82099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.32099915 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.39599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.89599609 58.52199936 Tm [(hum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ans.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.85300064 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.35300064 74.12200165 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.0759964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.5759964 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.49099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.99099731 74.12200165 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.16000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.66000366 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.60099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.10099792 74.12200165 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.4730072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.9730072 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.89500427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.39500427 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.13101196 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 0.75 m 135.1000061 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 17.10000038 m 135.1000061 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 33.45000076 m 135.1000061 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 49.80000305 m 135.1000061 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 66.15000153 m 135.1000061 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 82.5 m 135.1000061 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 98.84999847 m 135.1000061 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.1000061 115.19999695 m 135.1000061 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92501831 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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