%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.33000183 23.67700005 Tm 0 g [(TCF25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.26600647 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.26600647 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.97000122 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(TC)-1(F25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 83.93299866 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.93299866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TC)-1(F25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.18299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.55699921 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.75900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.13300323 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.11300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.48699951 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.96099854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transcripti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.83799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.21199799 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.60099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.9750061 12.82499981 Tm [(25;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.42799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.80200195 12.82499981 Tm [(Hul)-1(p1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.29200745 12.82499981 Tm [(NU)1(L)-1(P)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.7769928 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.15100098 12.82499981 Tm [(FKSG26;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.70599365 12.82499981 Tm [(PRO26)1(20;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.88000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.2539978 12.82499981 Tm [(hKIA)1(A1049)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.30899048 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(477-6)1(76)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(TC)-1(F25)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 338.24899292 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.58399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08399963 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.20300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.70300293 11.72200012 Tm [(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.25900269 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(lp)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.09399986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.59400177 11.72200012 Tm [(NULP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.1989975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.6989975 11.72200012 Tm [(FKSG26)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.8030014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.3030014 11.72200012 Tm [(PRO262)-1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.29699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.79699707 11.72200012 Tm [(hK)1(IAA10)-1(49)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.4730072 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(Q70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14899826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(09)-1(34)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 132.125 47.54999924 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.9129982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4129982 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.38800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.88800049 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.54799652 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.04799652 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.98899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.48899841 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.89900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.39900208 11.72200012 Tm [(deat)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.1309967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.6309967 11.72200012 Tm [(control.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.48500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.98500061 11.72200012 Tm [(Acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.3500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.8500061 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.99099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.49099731 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.46600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.96600342 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.92001343 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(repressor)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.49100113 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.99100113 27.3220005 Tm [(Has)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.0929985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.59300232 27.3220005 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09999847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.59999847 27.3220005 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.18099976 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.2559967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.7559967 27.3220005 Tm [(repress)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.92199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.42199707 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.0059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.5059967 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.3480072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.8480072 27.3220005 Tm [(SRF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.69900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.19900513 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.14001465 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.64001465 27.3220005 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(itro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.90600014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.40600014 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18299866 42.92200089 Tm [(so)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.07099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.57099915 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.74199677 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.24199677 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.1230011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.6230011 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.59799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.09799957 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.75800323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.25799561 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19900513 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.69900513 42.92200089 Tm [(heart)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.11099243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.61099243 42.92200089 Tm [(development.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.7749939 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 0.75 m 131.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 17.10000038 m 131.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 33.45000076 m 131.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 49.80000305 m 131.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 66.15000153 m 131.75 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 82.5 m 131.75 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 98.84999847 m 131.75 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 115.19999695 m 131.75 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 545.87902832 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>