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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.94499969 23.67700005 Tm 0 g [(TAB1)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 137.65100098 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.65100098 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.35501099 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(TAB1)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 85.22499847 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.47499847 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.4750061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TAB1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 85.22499847 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 87.59899902 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 120.8010025 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 123.17500305 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 183.15499878 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 185.52900696 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 220.00300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TGF)-1(-beta)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 102.06700134 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 104.44100189 12.82499981 Tm [(activate)1(d)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 143.86700439 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 146.24099731 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 173.30099487 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 175.67500305 12.82499981 Tm [(1/MAP)1(3K7)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 221.62800598 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 224.0019989 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 255.83000183 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 258.20401001 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 289.58599854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 291.95999146 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 300.09100342 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 302.46499634 12.82499981 Tm [(3'-Tab1;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 337.11300659 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 339.48699951 12.82499981 Tm [(MAP)1(3K7)1(IP1)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 389.45401001 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 57 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 58 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(64-36)1(8)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(TAB1)] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAABB 9 Tf 1 0 0 -1 330.29400635 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 86 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 87 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 89 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TGF-b)1(e)-1(t)1(a)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 39.70899963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 44.20899963 11.72200012 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 83.36000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 87.86000061 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 114.94799805 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 119.44799805 11.72200012 Tm [(1/)-1(MA)1(P3)-1(K)1(7)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 165.47200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 169.97200012 11.72200012 Tm [(binding)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 203.11599731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 207.61599731 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 238.92300415 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 243.42300415 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 248.70100403 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(3')-1(-)1(T)-1(a)1(b1;)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 34.80500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 39.30500031 11.72200012 Tm [(MAP)1(3)-1(K7IP1)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 89.63600159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 115 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q15)-1(75)-1(0)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 118 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 121 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 122 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(50)-1(55)-1(4)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 124 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 125 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 145 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 146 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 151 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 118.52500153 16.35000038 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 117.77500153 0.75 l 117.77500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 118.77500153 -0.25 l 118.77500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 164 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 165 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 118.52500153 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 118.52500153 109.94999695 l h f* Q q 1 0 0 1 118.15000153 0 cm -0.625 -0.25 m 309.0249939 -0.25 l 309.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 166 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 175.352005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 179.852005 11.72200012 Tm [(identified)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 220.78300476 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 225.28300476 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 234.42399597 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 238.92399597 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 243.89900208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 248.39900208 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 288.12600708 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 292.62600708 11.72200012 Tm [(o)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 21.62100029 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 26.12100029 27.3220005 Tm [(MAP)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 46.75299835 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 51.25299835 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 78.34100342 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 82.84100342 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 109.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 114.42900085 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 141.51699829 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 146.01699829 27.3220005 Tm [(MAP)1(3)-1(K7/T)-1(A)1(K1,)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 211.41200256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 215.91200256 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 241.00900269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 245.50900269 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 252.07000732 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 256.57000732 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 285.38900757 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 289.88900757 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 298.96398926 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 35.125 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 39.625 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 70.58899689 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 75.08899689 42.92200089 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 125.55599976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 130.05599976 42.92200089 Tm [(signaling)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 168.98699951 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 173.48699951 42.92200089 Tm [(pa)1(thw)1(ays,)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 216.28100586 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 220.78100586 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 240.54800415 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 245.04800415 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 254.18899536 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 258.68899536 42.92200089 Tm [(th)1(ose)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 282.57800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 287.07800293 42.92200089 Tm [(ind)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(uc)-1(ed)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 20.92200089 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 25.42200089 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 35.93399811 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 40.43399811 58.52199936 Tm [(TGF)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 57.06700134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 61.56700134 58.52199936 Tm [(beta)1(,)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 82.91600037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 87.41600037 58.52199936 Tm [(interle)-1(ukin)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 133.14100647 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 137.64100647 58.52199936 Tm [(1,)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 145.08500671 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 149.58500671 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 165.86199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 170.36199951 58.52199936 Tm [(WNT-)1(1)-1(.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 203.33399963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 207.83399963 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 225.09599304 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 229.59599304 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 260.90301514 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 265.40301514 58.52199936 Tm [(interact)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 4.16599989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 8.66600037 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 24.94300079 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 29.44300079 74.12200165 Tm [(th)1(us)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 48.04899979 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 52.54899979 74.12200165 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 90.10900116 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 94.60900116 74.12200165 Tm [(TAK1)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 117.09100342 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 121.59100342 74.12200165 Tm [(ki)-1(na)1(se)-1(.)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 150.84500122 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 155.34500122 74.12200165 Tm [(It)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 161.34399414 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 165.84399414 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 180.52600098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 185.02600098 74.12200165 Tm [(been)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 206.53300476 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 211.03300476 74.12200165 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 239.11399841 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 243.61399841 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 260.83599854 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 265.33599854 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 279.33700562 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 283.83700562 74.12200165 Tm [(C-t)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ermin)-1(a)1(l)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 32.28699875 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 36.78699875 89.72200012 Tm [(po)1(rtion)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 68.70899963 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 73.20899963 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 82.0510025 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 86.5510025 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 102.00700378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 106.50700378 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 137.81399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 142.31399536 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 148.875 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 153.375 89.72200012 Tm [(suff)1(i)-1(cie)-1(nt)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 192.63600159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 197.13600159 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 209.41400146 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 213.91400146 89.72200012 Tm [(binding)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 247.05799866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 251.55799866 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 267.83499146 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 272.33499146 89.72200012 Tm [(activat)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ion)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 13.66300011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 18.16300011 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 27.00499916 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 31.50499916 105.3219986 Tm [(TAK1,)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 56.15399933 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 60.65399933 105.3219986 Tm [(wh)1(il)-1(e)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 83.19799805 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 87.69799805 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 92.67299652 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 97.17299652 105.3219986 Tm [(po)1(rtion)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 129.09500122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 133.59500122 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 142.43699646 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 146.93699646 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 160.93800354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 165.43800354 105.3219986 Tm [(N-t)1(e)-1(r)1(mi)-1(nus)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 214.63000488 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 219.13000488 105.3219986 Tm [(acts)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 236.13699341 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 240.63699341 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 249.77799988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 254.27799988 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 259.25299072 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 263.75299072 105.3219986 Tm [(do)1(mi)-1(na)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 0.75 m 118.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 17.10000038 m 118.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 33.45000076 m 118.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 49.80000305 m 118.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 66.15000153 m 118.15000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 82.5 m 118.15000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 98.84999847 m 118.15000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.15000153 115.19999695 m 118.15000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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