%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.95899963 23.67700005 Tm 0 g [(SWAP70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.63600159 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.63600159 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.33999634 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(SWAP)1(70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.55899811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 109.80899811 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 193.80900574 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SWAP)1(70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.30899811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.68299866 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.88499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.25900269 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.23899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.61300659 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.08700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SWAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.04000092 12.82499981 Tm [(switch)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.40499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.77900696 12.82499981 Tm [(B-cell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.18899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.56300354 12.82499981 Tm [(compl)-1(e)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.62600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198 12.82499981 Tm [(70k)1(Da)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.90600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.27999878 12.82499981 Tm [(su)-1(bun)-1(it;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.18899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.56298828 12.82499981 Tm [(HS)-1(P)1(C321;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.72698975 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.10101318 12.82499981 Tm [(SWAP)1(-70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.625 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SWAP)1(70)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 289.00299072 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SWA)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.19099998 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.69099998 11.72200012 Tm [(sw)1(i)-1(t)1(c)-1(h)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.46299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.96299744 11.72200012 Tm [(B-c)-1(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.91300201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.41300201 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.89199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.39199829 11.72200012 Tm [(70)-1(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.67799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.17799377 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.47799683 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HS)-1(P)1(C3)-1(21)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.68199921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.18199921 11.72200012 Tm [(SWA)1(P-70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.82299805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UH6)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.84799957 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(61)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 136.42500305 109.94999695 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pho)1(spha)1(tidylinosito)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.55699921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.05699921 11.72200012 Tm [(3,4)-1(,)1(5)-1(-)1(trisp)1(hosp)1(hat)1(e)-1(-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.28799438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.78799438 11.72200012 Tm [(guanine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.15899658 11.72200012 Tm [(nu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cl)-1(eot)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.34799957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.84799957 27.3220005 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.95400238 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.45400238 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.57299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.07299805 27.3220005 Tm [(\(GE)1(F)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.50700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.00700378 27.3220005 Tm [(wh)1(ic)-1(h,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.27099609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.77099609 27.3220005 Tm [(indepen)-1(d)1(e)-1(nt)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.89599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.39599609 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.23800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.73800659 27.3220005 Tm [(RA)1(S)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.30700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.80700684 27.3220005 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ransd)1(u)-1(ces)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.21099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.71099854 42.92200089 Tm [(signals)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.11000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.61000061 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.32099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.82099915 42.92200089 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.30900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.80900574 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.89700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.39700317 42.92200089 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.98500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.48500061 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.55999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.05999756 42.92200089 Tm [(RA)1(C.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.45498657 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.95498657 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.95401001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.45401001 42.92200089 Tm [(als)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 58.52199936 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.51399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.01399994 58.52199936 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.94499969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.44499969 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.28700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.78700256 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.57099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07099915 58.52199936 Tm [(ruff)1(l)-1(ing)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.55299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05299377 58.52199936 Tm [(Regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.33299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.83299255 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.83401489 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.33401489 58.52199936 Tm [(acti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.69200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.19200134 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.33300018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.83300018 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35399628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.85399628 74.12200165 Tm [(effec)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.33200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.83200073 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.99000549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.49000549 74.12200165 Tm [(ad)1(apt)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.83999634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.33999634 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.64700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.14700317 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.08799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.58799744 74.12200165 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.58499146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.08499146 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 89.72200012 Tm [(ag)1(onist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.13499832 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.63499832 89.72200012 Tm [(st)1(i)-1(mulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.11399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61399841 89.72200012 Tm [(ph)1(osph)1(atid)1(y)-1(linosito)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.41200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.91200256 89.72200012 Tm [(\(3,4)-1(\)-)1(bisph)1(osph)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.74899292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.24899292 89.72200012 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(rod)1(uc)-1(t)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.99000168 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49000168 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.76699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.26699829 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.67700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.17700195 105.3219986 Tm [(pro)1(trusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.24699402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.74699402 105.3219986 Tm [(\(By)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.16400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.66400146 105.3219986 Tm [(similarit)1(y)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.54299927 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 0.75 m 136.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 17.10000038 m 136.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 33.45000076 m 136.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 49.80000305 m 136.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 66.15000153 m 136.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 82.5 m 136.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 98.84999847 m 136.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 115.19999695 m 136.05000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream 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