%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.00299835 23.67700005 Tm 0 g [(SU)1(LT2B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.59199524 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.59199524 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.29598999 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SULT)-1(2B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4469986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.6969986 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.69700623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SULT)-1(2B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4469986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.82099915 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.022995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.39700317 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.3769989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.75100708 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.2250061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(su)-1(lfo)-1(t)1(ran)-1(sfe)1(rase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.42900085 12.82499981 Tm [(fami)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.24200439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.61599731 12.82499981 Tm [(cy)1(to)-1(sol)-1(ic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.38600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.75999451 12.82499981 Tm [(2B,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.41299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.78700256 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.18798828 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.56201172 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.69299316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.06698608 12.82499981 Tm [(HS)-1(ST2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.6960144 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(165)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SULT)-1(2B1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 289.97900391 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(sulfot)1(ransfera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83499908 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.08300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.58300018 11.72200012 Tm [(cy)-1(t)1(osolic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.79200745 11.72200012 Tm [(2B)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88299561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.38299561 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.64700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.14700317 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.42500305 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HS)-1(ST2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.78700066 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O00)-1(20)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(34)-1(69)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 142.42500305 109.94999695 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sulfot)1(ransferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.86299896 11.72200012 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.41000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.91000366 11.72200012 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.41600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.91600037 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.91700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.41700745 11.72200012 Tm [(sulfat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.07800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.57800293 11.72200012 Tm [(conj)-1(ug)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.05599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.55599976 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.39801025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.71699905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.21699905 27.3220005 Tm [(ho)1(rmone)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55599976 27.3220005 Tm [(ne)-1(uro)1(transmit)1(ters,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.79800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.29800415 27.3220005 Tm [(dr)1(u)-1(g)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.1269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.6269989 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.90400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.40400696 27.3220005 Tm [(xenobiot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.46600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.96600342 27.3220005 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mpo)1(u)-1(nd)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.08399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.58399963 42.92200089 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.66400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.16400146 42.92200089 Tm [(cy)-1(t)1(osolic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.70600128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.20600128 42.92200089 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75300598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25300598 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.77099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27099609 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.21099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.71099854 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.6519928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.1519928 42.92200089 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.98500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.48498535 42.92200089 Tm [(tiss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.65200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15200043 58.52199936 Tm [(dist)1(ributio)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.12999725 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.62999725 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.90699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.40699768 58.52199936 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.25700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.75700378 58.52199936 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.29600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.79600525 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.60299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.10299683 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.6190033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.1190033 58.52199936 Tm [(st)1(ruc)-1(tur)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(\(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.4280014 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.9280014 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.20500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.70500183 74.12200165 Tm [(len)-1(g)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.40399933 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.90399933 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.7460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.2460022 74.12200165 Tm [(exons\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.35299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.85299683 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.41400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91400146 74.12200165 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.10899353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.60899353 74.12200165 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.04100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.54100037 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.6230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.12298584 74.12200165 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mbers.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.55699921 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.81900024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31900024 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.83499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.33499908 89.72200012 Tm [(sulfat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.16200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.66200256 89.72200012 Tm [(dehydro)1(e)-1(p)1(iandrost)1(erone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.86700439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.36700439 89.72200012 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.01400757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.51400757 89.72200012 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.13500977 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.63500977 89.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(-nitr)1(oph)1(e)-1(nol,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.57099915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.07099915 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.04599762 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.54599762 105.3219986 Tm [(typical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.68900299 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.18900299 105.3219986 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.53900146 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.81700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.31700134 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.31799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.81799316 105.3219986 Tm [(ph)1(e)-1(nol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.8769989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.3769989 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.65400696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.15400696 105.3219986 Tm [(estro)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.34698486 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 17.10000038 m 142.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 33.45000076 m 142.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 49.80000305 m 142.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 66.15000153 m 142.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 82.5 m 142.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 98.84999847 m 142.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 115.19999695 m 142.05000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>