%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.5039978 23.67700005 Tm 0 g [(SU)1(LT2A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.09199524 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 165.09199524 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.79598999 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SULT)-1(2A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.81099701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.06099701 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 190.06100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SULT)-1(2A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.81099701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.18499756 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.38699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.76100159 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.74099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.11500549 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.58900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(su)-1(lfo)-1(t)1(ran)-1(sfe)1(rase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.91400146 12.82499981 Tm [(fami)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.727005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.58599854 12.82499981 Tm [(cy)1(to)-1(sol)-1(ic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.35600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.21499634 12.82499981 Tm [(2A)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.23199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.09100342 12.82499981 Tm [(dehydroepi)-1(and)-1(r)1(o)-1(ste)1(ron)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.01400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.87298584 12.82499981 Tm [(\(DH)-1(EA)1(\))-1(-pre)1(f)-1(e)1(rr)1(i)-1(ng,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.40100098 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.77500153 30.49699783 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.90599823 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.27999878 30.49699783 Tm [(HS)-1(T;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.57299805 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.9469986 30.49699783 Tm [(ST)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.01999664 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.39399719 30.49699783 Tm [(ST)-1(D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60500336 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.97899628 30.49699783 Tm [(hS)-1(Ta;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.27600098 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.6499939 30.49699783 Tm [(DHE)-1(A)1(S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.48800659 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.86199951 30.49699783 Tm [(ST)-1(2A)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.33200073 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.70599365 30.49699783 Tm [(ST)-1(2A)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.36599731 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.32099915 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.35600281 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.3809967 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.06599426 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.10099792 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.14199829 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.17700195 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.60800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64300537 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.13600159 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.17100525 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.85699463 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89199829 12.04500008 Tm [(SULT)-1(2A)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 291.30200195 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 146.92500305 31.95000076 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(sulfot)1(ransfera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.33499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.83499908 11.72200012 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.08300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.58300018 11.72200012 Tm [(cy)-1(t)1(osolic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.79200745 11.72200012 Tm [(2A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.56900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.06900024 11.72200012 Tm [(dehydro)1(e)-1(p)1(iandrost)1(eron)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(\(DHEA\)-)1(preferring,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.86299896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.36299896 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.6269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.1269989 27.3220005 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.40499878 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HS)-1(T;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.4810009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.9810009 11.72200012 Tm [(ST2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.77899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.27899933 11.72200012 Tm [(STD;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.65399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.15399933 11.72200012 Tm [(hSTa;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.69000244 11.72200012 Tm [(DHEAS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.147995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.647995 11.72200012 Tm [(ST2)-1(A)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.05599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.55599976 11.72200012 Tm [(ST2)-1(A)1(3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.96400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.46400452 11.72200012 Tm [(DHEA-)1(ST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80799866 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q06)-1(52)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(20)-1(75)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 146.92500305 78.75 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(sulfot)1(ransfera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.61199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.11199951 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.35998535 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(Sulfot)1(ransferases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.52899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.02899933 27.3220005 Tm [(aid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.15499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.65499878 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.59600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.09600067 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.09700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.59700012 27.3220005 Tm [(metab)1(olism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.82299805 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.66499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.16499329 27.3220005 Tm [(dr)1(u)-1(g)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.82699585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.32699585 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.10400391 27.3220005 Tm [(en)-1(d)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(genous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.3429985 42.92200089 Tm [(compounds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.49500275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.99500275 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.50700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.00700378 42.92200089 Tm [(conve)-1(rt)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.10600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.60600281 42.92200089 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.8789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.3789978 42.92200089 Tm [(subst)1(anc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.66400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.16400146 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.17999268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.67999268 42.92200089 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ore)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.26500034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.76499939 58.52199936 Tm [(hydro)1(philic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.97299957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.47299957 58.52199936 Tm [(wa)1(ter-so)1(lu)-1(b)1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.42100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.92100525 58.52199936 Tm [(sulfat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.58200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.08200073 58.52199936 Tm [(conj)-1(ug)1(ates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.16900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.66900635 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.89100647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.39100647 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42498779 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.92498779 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.7789917 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(easily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.8010006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.3010006 74.12200165 Tm [(exc)-1(ret)1(e)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.40799713 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.90799713 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.16999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.66999817 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.97699738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.477005 74.12200165 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.14900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.64900208 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.6499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.1499939 74.12200165 Tm [(sulfat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.36700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.86700439 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.70899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.20899963 74.12200165 Tm [(st)1(e)-1(ro)1(i)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 0.75 m 146.55000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 32.70000076 m 146.55000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 49.05000305 m 146.55000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 65.40000153 m 146.55000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 81.75 m 146.55000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 98.09999847 m 146.55000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 114.44999695 m 146.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 130.80000305 m 146.55000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>