%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.95999908 23.67700005 Tm 0 g [(SRPK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.63499451 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.63499451 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.33898926 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SRPK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.72699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.97699738 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.977005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SRPK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.72699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.10099792 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.3030014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.67700195 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.65699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.03100586 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.50500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SRS)-1(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.17500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5490036 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.93099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.30500031 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.36500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.73899841 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.86999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.2440033 12.82499981 Tm [(SF)-1(RSK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.19500732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(451-6)1(55)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(SRPK1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 338.71499634 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SRSF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.04500008 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.54500008 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.85200119 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.35200119 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.44000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.94000244 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.21800232 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SFRSK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.0359993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(SB4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.00899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(38)-1(29)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 131.17500305 109.94999695 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(serine)-1(/arg)1(in)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.42799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.92799377 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.73500061 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.82299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.32299805 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.27999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.77999878 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.05801392 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 27.3220005 Tm [(SR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.57099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.07099915 27.3220005 Tm [(\(serine)-1(/arg)1(in)-1(ine-rich)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.61399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.11399841 27.3220005 Tm [(do)1(main\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.94700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.44700623 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.52900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.02900696 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.8710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.3710022 27.3220005 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.28599548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.78599548 27.3220005 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.23800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 42.92200089 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.20600128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.70600128 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.78099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.28099823 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.28199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.78199768 42.92200089 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.6000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.1000061 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.3769989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.8769989 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.87800598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.37800598 42.92200089 Tm [(cy)-1(t)1(oplas)1(m.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.61300659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.11300659 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.11199951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.61199951 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.17300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.67300415 42.92200089 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ough)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.91900063 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.41900063 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.49399948 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.99399948 58.52199936 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.375 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.34999847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.84999847 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.51000214 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.01000214 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.9509964 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.4509964 58.52199936 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.68200684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.18200684 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.02400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.52400208 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.88800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.38800049 58.52199936 Tm [(constitut)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.55999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.05999756 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.33700562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.83700562 58.52199936 Tm [(alt)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5359993 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0359993 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9509964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.4509964 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.96299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.46299744 74.12200165 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.72900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.22900391 74.12200165 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.69599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.19599915 74.12200165 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.0059967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.5059967 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.3480072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.84799194 74.12200165 Tm [(splicin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.70899963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.20899963 89.72200012 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.93199921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.43199921 89.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.34700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.84700012 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.68899536 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.18899536 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.64500427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.14500427 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.66099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.16099548 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.33000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.83000183 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.77099609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.27099609 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.64300537 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.14300537 89.72200012 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(anscript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.13199997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.63199997 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.36799622 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 0.75 m 130.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 17.10000038 m 130.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 33.45000076 m 130.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 49.80000305 m 130.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 66.15000153 m 130.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 82.5 m 130.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 98.84999847 m 130.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 115.19999695 m 130.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q q 1 0 0 1 0 608.2789917 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>