%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.40100098 23.67700005 Tm 0 g [(SRP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.19500732 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.19500732 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.89898682 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SRP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59400177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 94.84400177 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.84399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SRP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59400177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.96800232 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.16999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54399872 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.52400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.897995 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.37199402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(si)-1(g)1(n)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41500092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.78900146 12.82499981 Tm [(re)1(cogni)-1(tio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.87399292 12.82499981 Tm [(particl)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.08200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.45599365 12.82499981 Tm [(14;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.28300476 12.82499981 Tm [(ALURBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.34599304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-136)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(SRP14)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 329.47601318 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2329998 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.7329998 11.72200012 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.22399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.72399902 11.72200012 Tm [(pa)1(rticle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.64600372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.14600372 11.72200012 Tm [(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.70199585 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ALU)1(RB)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.69900131 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P37)-1(10)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(35)-1(49)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 135.67500305 16.35000038 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 134.92500305 0.75 l 134.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 135.92500305 -0.25 l 135.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 135.67500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 135.67500305 94.34999847 l h f* Q q 1 0 0 1 135.30000305 0 cm -0.625 -0.25 m 291.875 -0.25 l 291.875 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Signal-r)1(e)-1(cognitio)1(n)-1(-)1(par)1(tic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.46199799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.96199799 11.72200012 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.71499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.21499634 11.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.89700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.39700317 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.37199402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.87199402 11.72200012 Tm [(cru)-1(cial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.14500427 11.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80499268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.30499268 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.2460022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.7460022 11.72200012 Tm [(ta)1(rge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.0510006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.5510006 27.3220005 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.15499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.65499878 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.12799835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.62799835 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.20300293 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.20399475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.70399475 27.3220005 Tm [(roug)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.70599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.20599365 27.3220005 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.96200562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.46200562 27.3220005 Tm [(reticu)-1(lum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.18600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.68600464 27.3220005 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(embrane.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.51800156 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.01800156 42.92200089 Tm [(SRP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.87200165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.37200165 42.92200089 Tm [(to)1(gether)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.74700165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.24700165 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14300537 42.92200089 Tm [(SRP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.2749939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.7749939 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.05200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55200195 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.55299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.05299377 42.92200089 Tm [(Alu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.32600403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.82600403 42.92200089 Tm [(po)1(rtion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.74798584 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.24798584 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.08999634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.58999634 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 58.52199936 Tm [(SRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.72400093 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.22399902 58.52199936 Tm [(RNA)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.91500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.41500092 58.52199936 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.63400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.13400269 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.13499451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.63499451 58.52199936 Tm [(elongat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.15100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.65100098 58.52199936 Tm [(arr)1(e)-1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.12399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.62399292 58.52199936 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.45100403 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.95100403 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.79299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.29299927 58.52199936 Tm [(SRP.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.03601074 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 74.12200165 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.7859993 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.2859993 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.12799835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.62799835 74.12200165 Tm [(SRP9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.48200226 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.98200226 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.25900269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.75900269 74.12200165 Tm [(SRP14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.89100647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.39100647 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.95199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.45199585 74.12200165 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.99299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.49299622 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.77099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.27099609 74.12200165 Tm [(SRP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.84700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.34700012 74.12200165 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.87200928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.37200928 74.12200165 Tm [(bin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ding.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.62100029 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 0.75 m 135.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 17.10000038 m 135.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 33.45000076 m 135.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 49.80000305 m 135.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 66.15000153 m 135.30000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 82.5 m 135.30000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 98.84999847 m 135.30000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 135.30000305 115.19999695 m 135.30000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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