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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.71900177 23.67700005 Tm 0 g [(SN)1(X4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.87600708 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.87600708 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.57998657 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SNX4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.37400055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.62400055 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.62399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SNX4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.37400055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.7480011 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.94999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3239975 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.30400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.67799377 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.1519928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(sorti)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.69000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.06400299 12.82499981 Tm [(nexi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.27899933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.65299988 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.78399658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.15800476 12.82499981 Tm [(ATG24)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.32899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 7.5 Tf 1 0 0 -1 0 11.53299999 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.93700027 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63299942 11.53299999 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.04899979 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.74499893 11.53299999 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.73400116 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.43000031 11.53299999 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.89700317 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.59300232 11.53299999 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.18599701 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.88200378 11.53299999 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.375 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.07099915 11.53299999 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.13900757 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.83500671 11.53299999 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.68499756 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.3809967 11.53299999 Tm [(200-4)1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.48500061 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.18099976 11.53299999 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.3809967 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.07699585 11.53299999 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.43600464 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.13200378 11.53299999 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.37600708 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.07200623 11.53299999 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.47698975 11.53299999 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.17300415 11.53299999 Tm [(SNX4)] TJ ET EMC /P <> BDC BT /FAAABB 7.5 Tf 1 0 0 -1 279.1539917 11.53299999 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.875 11.72200012 Tm [(ne)-1(x)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.02999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.52999878 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.80799866 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATG24B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.38700104 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O95)-1(21)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(18)-1(76)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 148.42500305 109.94999695 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.6519928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.1519928 11.72200012 Tm [(ne)-1(x)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.30700684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.80700684 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.05499268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.29000092 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.13199997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.63199997 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.08799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.58799744 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16999817 27.3220005 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.21899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.71899414 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.69400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19400024 27.3220005 Tm [(ph)1(ox)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.76699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.26699829 27.3220005 Tm [(\(PX\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08999634 27.3220005 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.08399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.58399963 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.0359993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.5359993 42.92200089 Tm [(ph)1(osph)1(oinositide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55899811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.05899811 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.20300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.70300293 42.92200089 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.69700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.19700623 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.47399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.97399902 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.49200439 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.99200439 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.36099243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.86099243 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.80200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.46699905 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.96699905 58.52199936 Tm [(tr)1(aff)1(i)-1(cki)-1(ng)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.64399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.14399719 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90599823 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.21299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.71299744 58.52199936 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.83999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.33999634 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.73599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.23599243 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.23699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.73699951 58.52199936 Tm [(lon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.25099945 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.75099945 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.5929985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.0929985 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.09400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.59400177 74.12200165 Tm [(leptin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.13700104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63700104 74.12200165 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.05900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.55900574 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.83599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.33599854 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.73199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.23199463 74.12200165 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.65400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.15400696 74.12200165 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.64199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.25399971 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.75400162 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.0320015 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5320015 89.72200012 Tm [(plat)1(el)-1(et-)1(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.13899994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.63899994 89.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.55499268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.05499268 89.72200012 Tm [(fa)1(c)-1(t)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.34100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.84100342 89.72200012 Tm [(insul)-1(in,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.9960022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.4960022 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.772995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.272995 89.72200012 Tm [(epid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ermal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.34600067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.84600067 105.3219986 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.76200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.26200104 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.3809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.8809967 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.8219986 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.3219986 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.73200226 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.23200226 105.3219986 Tm [(cu)-1(lt)1(u)-1(r)1(e)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.46099854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.96099854 105.3219986 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.60800171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.10800171 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.02200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.52200317 105.3219986 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.26300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.76300049 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.32400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.82400513 105.3219986 Tm [(unk)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 0.75 m 148.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 17.10000038 m 148.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 33.45000076 m 148.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 49.80000305 m 148.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 66.15000153 m 148.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 82.5 m 148.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 98.84999847 m 148.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 115.19999695 m 148.05000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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