%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.76000214 23.67700005 Tm 0 g [(SMY)1(D)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83500671 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.83500671 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.53900146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SMY)-1(D3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.94999695 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.94999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SMY)-1(D3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.0739975 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.27600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.6499939 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.63000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.0039978 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.47799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.06800079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.44200134 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.50499725 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.8789978 12.82499981 Tm [(MYND)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.21099854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58500671 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.98199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.35600281 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.19099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.56500244 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.69599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.07000732 12.82499981 Tm [(KMT3E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.8769989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.25100708 12.82499981 Tm [(ZMY)-1(N)1(D1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.63101196 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.00500488 12.82499981 Tm [(ZNFN3A)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.82998657 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.20401001 12.82499981 Tm [(bA74P)1(14.1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.48001099 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(228)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SMY)-1(D3)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 284.19500732 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SET)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.30200005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.80200005 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.07899857 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.57899857 11.72200012 Tm [(MYND)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.97599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.47599792 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.3030014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.8030014 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.55000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.05000305 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.32800293 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(KMT3E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.05799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.55799866 11.72200012 Tm [(ZMYND)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.98100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.48100281 11.72200012 Tm [(ZNFN3)-1(A)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.53199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.03199768 11.72200012 Tm [(bA)1(7)-1(4P14)-1(.1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.17500305 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(7B)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.77600098 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(31)-1(01)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.17500305 16.35000038 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.42500305 0.75 l 130.42500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 131.42500305 -0.25 l 131.42500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.17500305 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 131.17500305 63.15000153 l h f* Q q 1 0 0 1 130.80000305 0 cm -0.625 -0.25 m 296.375 -0.25 l 296.375 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.5 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134 11.72200012 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.97900391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.47900391 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.57600403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.07600403 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.98300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9659996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.4659996 27.3220005 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.31800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81800079 27.3220005 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.10900116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.60900116 27.3220005 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.36000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.86000061 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.37199402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.87199402 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.39300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.89300537 27.3220005 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.23300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.73300171 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.6289978 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.10400391 27.3220005 Tm [(speci)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.02799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.52799988 42.92200089 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0530014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5530014 42.92200089 Tm [(helic)-1(as)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.91799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.41799927 42.92200089 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15000153 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.65000153 42.92200089 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.57200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.07200623 42.92200089 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.64199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.14199829 42.92200089 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.48399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.98399353 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.92401123 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65999985 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.00699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.50700378 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.01399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.51399994 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.20400238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.70400238 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.98199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.48199463 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.93800354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.43800354 58.52199936 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.11999512 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 0.75 m 130.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 17.10000038 m 130.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 33.45000076 m 130.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 49.80000305 m 130.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 66.15000153 m 130.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 82.5 m 130.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 98.84999847 m 130.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 130.80000305 115.19999695 m 130.80000305 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 426.92498779 177.9750061 l S Q Q q 1 0 0 1 0 561.47900391 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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