%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.73400116 23.67700005 Tm 0 g [(SLC29)1(A4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86199951 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.86199951 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.56600952 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SL)-1(C29A)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.12799835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.12800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SL)-1(C29A)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.2519989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.80799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.18200684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.65600586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(sol)-1(ute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08399963 12.82499981 Tm [(car)1(ri)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.16899872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.94100189 12.82499981 Tm [(fami)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.13499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.90699768 12.82499981 Tm [(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.55099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.32299805 12.82499981 Tm [(\(equ)-1(il)-1(ibrati)-1(v)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.09399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.86599731 12.82499981 Tm [(nu)-1(cleosi)-1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.76800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.54000854 12.82499981 Tm [(transpo)-1(r)1(ter\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.29098511 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.06298828 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.46398926 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.23599243 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 386.36700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.13900757 12.82499981 Tm [(ENT4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29199219 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(PMA)1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.59399986 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(240-3)1(39)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(SL)-1(C29A)1(4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 347.41598511 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 109.42500305 31.95000076 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(solute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.28800011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78800011 11.72200012 Tm [(carrier)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.0870018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.5870018 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66899872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16899872 11.72200012 Tm [(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.72499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22499847 11.72200012 Tm [(\(equili)-1(b)1(rat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.56300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.06300354 11.72200012 Tm [(nuc)-1(leoside)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.31500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.81500244 11.72200012 Tm [(tr)1(anspor)1(ter\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.26599121 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.76599121 11.72200012 Tm [(memb)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 27.3220005 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.32099915 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ENT4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.86899948 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.36899948 11.72200012 Tm [(PMA)1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.1609993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q7RTT)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.08399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(25)-1(32)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 109.42500305 78.75 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 318.125 -0.25 l 318.125 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(SLC2)-1(9A/ENT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.26800537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.76800537 11.72200012 Tm [(tr)1(anspor)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.04598999 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.54598999 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.29399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.79399872 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.60100174 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.10100174 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.60800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.10800171 27.3220005 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.89199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.39199829 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.69900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.19900513 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.8710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.3710022 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.37199402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.87199402 27.3220005 Tm [(reupta)1(k)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.04299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.54299927 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.38500977 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(monoa)1(mi)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.04299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.54299927 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.55899811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.05899811 42.92200089 Tm [(presynapt)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.80900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.30900574 42.92200089 Tm [(ne)-1(uro)1(n)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.54400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.04400635 42.92200089 Tm [(th)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.6499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.1499939 42.92200089 Tm [(determining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.98100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.48098755 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.48199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.98199463 42.92200089 Tm [(intensit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.54100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.04100037 58.52199936 Tm [(dura)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.76999664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.26999664 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.11199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.61199951 58.52199936 Tm [(monoa)1(mi)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.48899841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.98899841 58.52199936 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.99299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.49299622 58.52199936 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.59100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.09100342 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.08999634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.58999634 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.27200317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.77200317 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.2789917 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.7789917 58.52199936 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.85998535 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.35998535 58.52199936 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.95700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.45700073 74.12200165 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.36599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.86599731 74.12200165 Tm [(compounds,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.18499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.68499756 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.53500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.03500366 74.12200165 Tm [(serot)1(onin)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.19400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.69400024 74.12200165 Tm [(do)1(pamine)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.54199219 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.04199219 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.31900024 74.12200165 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 0.75 m 109.05000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 32.70000076 m 109.05000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 49.05000305 m 109.05000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 65.40000153 m 109.05000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 81.75 m 109.05000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 98.09999847 m 109.05000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 114.44999695 m 109.05000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 130.80000305 m 109.05000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>