%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 110 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.73400116 23.67700005 Tm 0 g [(SLC25)1(A2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86199951 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.86199951 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.56600952 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SL)-1(C25A)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.12799835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.12800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SL)-1(C25A)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.2519989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.80799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.18200684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.65600586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(sol)-1(ute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.76999664 12.82499981 Tm [(car)1(ri)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85500336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.31300354 12.82499981 Tm [(fami)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.50700378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.96499634 12.82499981 Tm [(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.60899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.06700134 12.82499981 Tm [(\(mi)-1(tochon)-1(drial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.13900757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.59700012 12.82499981 Tm [(car)1(ri)-1(e)1(r;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.49200439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.95001221 12.82499981 Tm [(orni)-1(thi)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.25799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.71600342 12.82499981 Tm [(transpo)-1(r)1(ter\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.84698486 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 367.30499268 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 403.70599365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 407.16400146 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29501343 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(ORC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.38299942 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.75699997 30.49699783 Tm [(ORNT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.6269989 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.32099915 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.35600281 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.3809967 12.04500008 Tm [(173)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.06599426 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.10099792 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.14199829 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.17700195 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.60800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64300537 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.13600159 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.17100525 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.85699463 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.89199829 12.04500008 Tm [(SL)-1(C25A)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 290.50201416 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 111.67500305 31.95000076 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(solute)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.28800011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78800011 11.72200012 Tm [(carrier)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.0870018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.5870018 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66899872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16899872 11.72200012 Tm [(25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.72499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22499847 11.72200012 Tm [(\(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.41400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.91400146 11.72200012 Tm [(carrier;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.3789978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.8789978 11.72200012 Tm [(ornit)1(hin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.41999817 11.72200012 Tm [(tr)1(anspor)1(ter\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.70401001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.26399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.76399994 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.04199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ORC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.67499924 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17499924 11.72200012 Tm [(ORNT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.13899994 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(XI2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.98800087 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(00)-1(93)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 111.67500305 16.35000038 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 110.92500305 0.75 l 110.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 111.92500305 -0.25 l 111.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 111.67500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 111.67500305 78.75 l h f* Q q 1 0 0 1 111.30000305 0 cm -0.625 -0.25 m 315.875 -0.25 l 315.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.04399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.54399872 11.72200012 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.61599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.11599731 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.11699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.61699677 11.72200012 Tm [(pro)1(tocad)1(he)-1(r)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.86799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.36799622 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.05000305 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.32699585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.82699585 11.72200012 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.39900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.89900208 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.41500854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.91500854 11.72200012 Tm [(cl)-1(ust)1(e)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.59698486 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.06300354 27.3220005 Tm [(5,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.50700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.00700378 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.46299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.96299744 27.3220005 Tm [(intro)1(n)-1(less)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.29499817 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.81100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.31100464 27.3220005 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.22799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.72799683 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.20300293 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.51000977 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.01000977 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.23199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.73199463 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.29299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.79299927 27.3220005 Tm [(hi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(gh)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.45700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.95700073 42.92200089 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.15200043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.65200043 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72699738 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22699738 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.7480011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.2480011 42.92200089 Tm [(ornit)1(hin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.28900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.78900146 42.92200089 Tm [(tr)1(anspor)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.06700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.56700134 42.92200089 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.75 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.69099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.19099426 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.19200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.69200134 42.92200089 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(ri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 58.52199936 Tm [(inn)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.90000153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.40000153 58.52199936 Tm [(membrane.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.35099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.85099792 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.65799713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.15799713 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.66499329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.16499329 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.97200012 58.52199936 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.64599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.14599609 58.52199936 Tm [(lik)-1(ely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.10099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.60099792 58.52199936 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.64801025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.14801025 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.12298584 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.62298584 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.2829895 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.7829895 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.72399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(metab)1(olism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.72600174 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.22600174 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.36699677 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.86699677 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84200287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.34200287 74.12200165 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.5249939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.0249939 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.75999451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.25999451 74.12200165 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.73300171 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 0.75 m 111.30000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 32.70000076 m 111.30000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 49.05000305 m 111.30000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 65.40000153 m 111.30000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 81.75 m 111.30000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 98.09999847 m 111.30000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 114.44999695 m 111.30000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 111.30000305 130.80000305 m 111.30000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>