%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.99900055 23.67700005 Tm 0 g [(SKI)1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.59700012 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 143.59700012 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 320.30099487 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SKIL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.33899689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.58899689 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.58900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SKIL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.33899689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.71299744 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.91500092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.28900146 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.26899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.64300537 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.11700439 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SKI-l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.95700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.33100128 12.82499981 Tm [(proto)-1(-on)-1(c)1(o)-1(g)1(ene;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.06199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.43600464 12.82499981 Tm [(SNO;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.80000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.17399597 12.82499981 Tm [(Sn)-1(oA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.93699646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.31100464 12.82499981 Tm [(Sn)-1(oI;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.64399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.01800537 12.82499981 Tm [(Sn)-1(oN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.67401123 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(235)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SKIL)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 272.74301147 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SKI-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.24300003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.74300003 11.72200012 Tm [(pro)1(to-)1(onc)-1(o)1(gen)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.63600159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SNO;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.01199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.51199913 11.72200012 Tm [(SnoA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.47299957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.97299957 11.72200012 Tm [(SnoI;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.24700165 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.74700165 11.72200012 Tm [(SnoN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.52600098 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P12)-1(75)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(59)-1(38)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 113.17500305 16.35000038 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 112.42500305 0.75 l 112.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 113.42500305 -0.25 l 113.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.17500305 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 113.17500305 109.94999695 l h f* Q q 1 0 0 1 112.80000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.33000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.83000183 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.67199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.17199707 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.17300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67300415 11.72200012 Tm [(SMAD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.34899902 11.72200012 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(at)1(hwa)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.88000107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38000107 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.47700119 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.97699738 27.3220005 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.81800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.31800079 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.22799683 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.14399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.64399719 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.92100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.42100525 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.74699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.24699402 27.3220005 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.14401245 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.64401245 27.3220005 Tm [(tr)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nsfor)1(min)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.12099838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.62099838 42.92200089 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.53700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.03700256 42.92200089 Tm [(fa)1(c)-1(t)1(or-b)1(e)-1(t)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.23199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73199463 42.92200089 Tm [(\(TGFB)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.19000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.69000244 42.92200089 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.8809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.3809967 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.38200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.88200378 42.92200089 Tm [(ab)1(se)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.04299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.54299927 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.38499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.88499451 42.92200089 Tm [(ligand)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.87600708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.37600708 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.37701416 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.00699997 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31400299 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.81400299 58.52199936 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.4260025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.9260025 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.00099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.50099945 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.5019989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.0019989 58.52199936 Tm [(pro)1(moter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.95899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.45899963 58.52199936 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.42100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.92100525 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.76300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.26300049 58.52199936 Tm [(TGFB)-1(-)1(responsive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.55300903 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.68199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.18199921 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.45899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.95899963 74.12200165 Tm [(rec)-1(ruit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41200256 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.38700104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.88700104 74.12200165 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.40499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.90499878 74.12200165 Tm [(repressor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.22900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.72900391 74.12200165 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.875 74.12200165 Tm [(TGFB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.15499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65499878 74.12200165 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.58599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.08599854 74.12200165 Tm [(cau)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43799973 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93799973 89.72200012 Tm [(SMAD3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.39199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89199829 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96699905 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46700287 89.72200012 Tm [(en)-1(t)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.01499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.51499939 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.51599884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.01599884 89.72200012 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.33399963 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.61099243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.11099243 89.72200012 Tm [(degra)1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.0059967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.5059967 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.96200562 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.46200562 89.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.93499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.43499756 89.72200012 Tm [(allow)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.52999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.02999878 105.3219986 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.7120018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.21199799 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.28700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.78700256 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.64099884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.14099884 105.3219986 Tm [(activat)1(ed.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.45799255 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.95799255 105.3219986 Tm [(Four)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.44299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94299316 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.86500549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.36500549 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.93499756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.43499756 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.77700806 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.27700806 105.3219986 Tm [(th)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 0.75 m 112.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 17.10000038 m 112.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 33.45000076 m 112.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 49.80000305 m 112.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 66.15000153 m 112.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 82.5 m 112.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 98.84999847 m 112.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.80000305 115.19999695 m 112.80000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>