%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.00800323 23.67700005 Tm 0 g [(SFTPA2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58700562 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 158.58700562 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.29098511 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SF)-1(TPA)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.58699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.83699799 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.83700562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SF)-1(TPA)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.58699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.96099854 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.16299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.53700256 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.51699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.89100647 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.36500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(su)-1(r)1(factan)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.53800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.44400024 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.82600403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.73199463 12.82499981 Tm [(A2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.93899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.84500122 12.82499981 Tm [(PSAP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.40299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.30900574 12.82499981 Tm [(PSPA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.86700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.772995 12.82499981 Tm [(SP-A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.1210022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.02700806 12.82499981 Tm [(SPA2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.48300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.38900757 12.82499981 Tm [(PSP-A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.1619873 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.06799316 12.82499981 Tm [(SF)-1(TP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 351.38900757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.29501343 12.82499981 Tm [(SP-2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.96499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.8710022 12.82499981 Tm [(SPAII;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29598999 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(COL)-1(EC5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.8219986 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.19599915 30.49699783 Tm [(SF)-1(TPA)1(2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.49500275 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-248)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(SF)-1(TPA)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 333.75698853 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(surfa)1(c)-1(t)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.98300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.48300171 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.79000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.29000092 11.72200012 Tm [(A2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.90000153 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 120.67500305 31.95000076 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PSAP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.70599937 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.20599937 11.72200012 Tm [(PSPA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.91199875 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.41199875 11.72200012 Tm [(SP-A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.50499725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.00499725 11.72200012 Tm [(SPA2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.48300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.98300171 11.72200012 Tm [(PSP-)1(A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.58299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.08299255 11.72200012 Tm [(SFT)-1(P)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.16799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.66799927 11.72200012 Tm [(SP-2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.03900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.53900146 11.72200012 Tm [(SPAII)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.02999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.52999878 11.72200012 Tm [(COLEC5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.91699219 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.41699219 11.72200012 Tm [(SFT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(PA)1(2)-1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.76399994 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IWL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.31200027 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(39)-1(72)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 120.67500305 16.35000038 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 119.92500305 0.75 l 119.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 120.92500305 -0.25 l 120.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.67500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 120.67500305 78.75 l h f* Q q 1 0 0 1 120.30000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.21299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.05500031 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.96399689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.46399689 11.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.64599609 11.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.98800659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.48800659 11.72200012 Tm [(pulmonary-)1(su)-1(r)1(factant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.9289856 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.1269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6269989 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09999847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.59999847 27.3220005 Tm [(\(SFT)-1(P)1(A\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.08499908 27.3220005 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.90600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.40600586 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.67399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.17399597 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.46899414 27.3220005 Tm [(10)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.19099426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.69100952 27.3220005 Tm [(Mutat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.56299973 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.06299973 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.57899857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.07900238 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.35600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.85600281 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.83100128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.33100128 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.72499847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.2250061 42.92200089 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.41999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91999817 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.43600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.93600464 42.92200089 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.75700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.25700378 42.92200089 Tm [(ne)-1(a)1(rby,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.99899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.49899292 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.5960083 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.0960083 42.92200089 Tm [(af)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(fec)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.09300041 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.59300041 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.59400177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.09400177 58.52199936 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.48799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98799896 58.52199936 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.56500244 58.52199936 Tm [(carbo)1(hydrat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.89199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.39199829 58.52199936 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.88299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.38299561 58.52199936 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.37701416 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.87701416 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.39498901 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.89498901 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ssociat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.65299988 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.04899979 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.5490036 74.12200165 Tm [(idiop)1(ath)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.34300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.84300232 74.12200165 Tm [(pulmonary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.40699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.90699768 74.12200165 Tm [(fib)1(rosis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.22200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.72200012 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52900696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.02900696 74.12200165 Tm [(cu)-1(rr)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.96699524 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.4670105 74.12200165 Tm [(version)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.56298828 74.12200165 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 0.75 m 120.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 17.10000038 m 120.30000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 49.05000305 m 120.30000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 65.40000153 m 120.30000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 81.75 m 120.30000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 98.09999847 m 120.30000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 114.44999695 m 120.30000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.30000305 130.80000305 m 120.30000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>