%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 117 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.02700043 23.67700005 Tm 0 g [(SE)1(T)-1(D3)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.56799316 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.27200317 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SE)-1(TD3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.09999847 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.1000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(TD3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.22399902 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.4260025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.80000305 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.77999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.15400696 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.62800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.06800079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.44200134 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.83899689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.21299744 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.04800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.42199707 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.55299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.92700195 12.82499981 Tm [(C14orf154)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.53700256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(97-29)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(SE)-1(TD3)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 334.25799561 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SET)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.30200005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.80200005 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.62900162 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.12900162 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.87599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.37599945 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.65399933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C14)-1(or)1(f15)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.68799973 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q86)-1(TU7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.04600143 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(09)-1(05)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 107.17500305 16.35000038 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 106.42500305 0.75 l 106.42500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 107.42500305 -0.25 l 107.42500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.17500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 107.17500305 63.15000153 l h f* Q q 1 0 0 1 106.80000305 0 cm -0.625 -0.25 m 316.625 -0.25 l 316.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)1(tone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.24900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.74900055 11.72200012 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.72799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.22799683 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.44999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.94999695 11.72200012 Tm [(methylat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14300537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.64300537 11.72200012 Tm [('L)-1(ys-)1(4)-1(')] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.477005 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.7539978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.2539978 11.72200012 Tm [('L)-1(ys-)1(3)-1(6')] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.86599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.36599731 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.20800781 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.70800781 11.72200012 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(to)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.72699928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.22699928 27.3220005 Tm [(H3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.4659996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.9659996 27.3220005 Tm [(\(H3)-1(K4me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.74099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.24099731 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.51799774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.01799774 27.3220005 Tm [(H3)-1(K36me)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.23699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.73699951 27.3220005 Tm [(Acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.102005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.602005 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.74299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.24299622 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.21800232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.71800232 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17199707 27.3220005 Tm [(activat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(Plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.47299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97299957 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.49399948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.99399948 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.95500183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.45500183 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11499786 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.61499786 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.05599976 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.05700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55700684 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.51100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.01100159 42.92200089 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.24200439 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.74200439 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.58401489 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.08401489 42.92200089 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.24398804 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.40999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.90999985 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.23600006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.73600006 58.52199936 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.83000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.33000183 58.52199936 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.16999817 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.56599426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.06599426 58.52199936 Tm [(MYOD)1(1)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.92500305 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 0.75 m 106.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 17.10000038 m 106.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 33.45000076 m 106.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 49.80000305 m 106.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 66.15000153 m 106.80000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 82.5 m 106.80000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 98.84999847 m 106.80000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 106.80000305 115.19999695 m 106.80000305 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 177.6000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.9750061 m 423.17498779 177.9750061 l S Q Q q 1 0 0 1 0 571.26202393 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 599.20098877 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>