%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 63.19100189 23.67700005 Tm 0 g [(SE)1(RP)-1(I)1(NA12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.40400696 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 175.40400696 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 352.10800171 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SE)-1(RP)1(INA)1(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.21900177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.46900177 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 199.46899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(RP)1(INA)1(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.21900177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.59300232 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.79499817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.16900635 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.14900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.522995 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.99699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ser)1(p)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.90699768 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.96899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.44099426 12.82499981 Tm [(in)-1(hi)-1(bi)-1(tor,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.0269928 12.82499981 Tm [(clad)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.64700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.1190033 12.82499981 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.19400024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.66600037 12.82499981 Tm [(\(al)-1(ph)-1(a-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.88800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.36000061 12.82499981 Tm [(anti)-1(protein)-1(ase)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.19500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.66699219 12.82499981 Tm [(anti)-1(tr)1(yps)-1(in\))-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.42401123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.89599609 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(12;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.45300007 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.82699966 30.49699783 Tm [(OL)-1(-64)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.05199814 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(214)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SE)-1(RP)1(INA)1(12)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 298.35501099 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 136.42500305 31.95000076 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(serpin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.39800072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.89800072 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.2519989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.7519989 11.72200012 Tm [(inhibito)1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.44999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.94999695 11.72200012 Tm [(cl)-1(a)1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.69599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.19599915 11.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.52900696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.02900696 11.72200012 Tm [(\(alph)1(a-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.83999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.33999634 11.72200012 Tm [(antip)1(rot)1(e)-1(inase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.32901001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.82901001 11.72200012 Tm [(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(itryp)1(sin)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.97600174 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.47600174 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.73999786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.23999786 27.3220005 Tm [(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.79599762 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(OL-64)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.40200043 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IW75)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.97200012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(40)-1(85)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.42500305 16.35000038 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 135.67500305 0.75 l 135.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 136.67500305 -0.25 l 136.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.42500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 136.42500305 31.95000076 l h f* Q q 1 0 0 1 136.05000305 0 cm -0.625 -0.25 m 291.125 -0.25 l 291.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ad)1(ipokin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.40100098 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.6230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.1230011 11.72200012 Tm [(mod)1(u)-1(la)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5759964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0759964 11.72200012 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.06500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.56500244 11.72200012 Tm [(action)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.06799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.56799316 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.08000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58000183 11.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.06500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.56500244 11.72200012 Tm [(inhibiti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 27.3220005 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.71699905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.21699905 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.1969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.6969986 27.3220005 Tm [(pro)1(tease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.30999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.80999756 27.3220005 Tm [(KLK7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.13200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.63200378 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.57299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.07299805 27.3220005 Tm [(wh)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.57499695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.07499695 27.3220005 Tm [(ad)1(ipose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.94400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.44400024 27.3220005 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.50900269 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 0.75 m 136.05000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 32.70000076 m 136.05000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 49.05000305 m 136.05000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 65.40000153 m 136.05000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 81.75 m 136.05000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 98.09999847 m 136.05000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 114.44999695 m 136.05000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.05000305 130.80000305 m 136.05000305 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 563.81799316 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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