%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 111 l -90 111 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 100 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 295.6000061 0 0 -98.65000153 0 98.65000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 153.55000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.17900085 23.67700005 Tm 0 g [(SE)1(P)-1(TI)1(N2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.41700745 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 162.41700745 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 339.1210022 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SE)-1(P)1(T)-1(IN)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.23799896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.48799896 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.48800659 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(P)1(T)-1(IN)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.23799896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.61199951 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.81399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.18800354 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.16799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.54200745 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01600647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(septi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.29100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.66500092 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.79599762 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.16999817 12.82499981 Tm [(DIF)-1(F6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.05599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.42999268 12.82499981 Tm [(NEDD5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.38600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.75999451 12.82499981 Tm [(SE)-1(P)1(T)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.38400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.75799561 12.82499981 Tm [(NEDD-5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.92900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.30299377 12.82499981 Tm [(Pnutl)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.81900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.19299316 12.82499981 Tm [(hNe)1(d)-1(d5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.06698608 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-371)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(SE)-1(P)1(T)-1(IN)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 336.88598633 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(septin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.31399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.81399918 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.09199905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DIFF6)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.50799942 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.00799942 11.72200012 Tm [(NEDD)1(5)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.4280014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.9280014 11.72200012 Tm [(SEPT2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.18000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.68000031 11.72200012 Tm [(NEDD)1(-5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.9940033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.4940033 11.72200012 Tm [(Pnutl3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.28500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.78500366 11.72200012 Tm [(hNedd)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.54100037 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q15)-1(01)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(33)-1(55)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 152.92500305 31.95000076 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.94799995 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 152.92500305 16.35000038 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 152.92500305 94.34999847 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Filame)-1(nt)1(-fo)1(rmin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.28700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.78700256 11.72200012 Tm [(cy)-1(t)1(oske)-1(letal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.53500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.03500366 11.72200012 Tm [(GTPa)1(se)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.80700684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.30700684 11.72200012 Tm [(Forms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.84599304 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.34599304 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.32099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.82099915 11.72200012 Tm [(filamentous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.45700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.95700073 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.35300064 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.85299683 27.3220005 Tm [(SEPTIN12)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.84600067 27.3220005 Tm [(SEPTIN6,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.06100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.56100464 27.3220005 Tm [(SEPTIN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.60899353 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.10899353 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.38600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.88600159 27.3220005 Tm [(pro)1(bab)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.92199707 27.3220005 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(EPTIN4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.85400009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.35400009 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.68199921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.18199921 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.18299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.68299866 42.92200089 Tm [(sperm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.57299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.07299805 42.92200089 Tm [(annulu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.79200745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.29200745 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.38900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.88900757 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.44999695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.94999695 42.92200089 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.49099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.99099731 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.26899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.76899719 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.77000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.27000427 42.92200089 Tm [(st)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(uc)-1(t)1(ural)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.76399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.26399994 58.52199936 Tm [(integrit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.3690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.8690033 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.14600372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.64600372 58.52199936 Tm [(mot)1(il)-1(it)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.45599365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.95599365 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.79800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.29800415 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.29899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.79899597 58.52199936 Tm [(sperm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.68899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.18899536 58.52199936 Tm [(ta)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.30700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.80700684 58.52199936 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.2440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.7440033 58.52199936 Tm [(po)1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mei)-1(o)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.91699982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.41699982 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.74299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.24299622 74.12200165 Tm [(\(PubMed:)1(2)-1(55)-1(88)-1(830)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.26699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.76699829 74.12200165 Tm [(Required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.7460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.2460022 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.52400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.02398682 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(orma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.96100044 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.46100044 89.72200012 Tm [(org)1(anizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.70700073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.20700073 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.0490036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.5490036 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.55000305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.05000305 89.72200012 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.83200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.33200073 89.72200012 Tm [(cy)-1(t)1(oske)-1(leton.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.14399719 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.64399719 89.72200012 Tm [(Plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.44999695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.94999695 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.92500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.42500305 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.08499146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.58499146 89.72200012 Tm [(i)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 0.75 m 152.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 17.10000038 m 152.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 33.45000076 m 152.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 49.80000305 m 152.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 66.15000153 m 152.55000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 98.1000061 m 152.55000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 114.45000458 m 152.55000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 130.80000305 m 152.55000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>