%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 102 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.55799866 23.67700005 Tm 0 g [(SE)1(NP7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03799438 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.03799438 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.74200439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SE)-1(N)1(P7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.47499847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.72499847 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.7250061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(N)1(P7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.47499847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.84899902 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.0510025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.42500305 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.40499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.77900696 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.25300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SUMO1/sentrin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.82000732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.19400024 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.94500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.31900024 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.3809967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.75500488 12.82499981 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.07699585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(801-1)1(000)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54100037 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57600403 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.61700439 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65200806 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.08300781 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.11801147 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.61099243 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.64599609 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.33200073 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.36700439 12.04500008 Tm [(SE)-1(N)1(P7)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 343.91699219 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SUMO1/se)-1(nt)1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.71299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.21299744 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.66999817 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.52400208 11.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.80200195 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(QF6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.65299988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(29)-1(98)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.92500305 16.35000038 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 137.17500305 0.75 l 137.17500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 138.17500305 -0.25 l 138.17500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.92500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 137.92500305 94.34999847 l h f* Q q 1 0 0 1 137.55000305 0 cm -0.625 -0.25 m 289.625 -0.25 l 289.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(reve)-1(r)1(sible)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.9280014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.4280014 11.72200012 Tm [(po)1(stt)1(ranslatio)1(n)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.647995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.147995 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.4730072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.9730072 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.81500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.31500244 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.78799438 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.28799438 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.79998779 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.29998779 11.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(ad)1(dition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.50500107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.00500107 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.84700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.34700012 27.3220005 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.71099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.21099854 27.3220005 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.08200073 27.3220005 Tm [(SUMO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.12399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.62399292 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.09700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.59700012 27.3220005 Tm [(\(see)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.98199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.48199463 27.3220005 Tm [(SUMO1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.89900017 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.39900017 42.92200089 Tm [(60)-1(19)-1(12)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.0719986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.5719986 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.13300323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.63300323 42.92200089 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1740036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.6740036 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.95199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.45199585 42.92200089 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.16900635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.66900635 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.43099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.93099976 42.92200089 Tm [(pro)1(c)-1(esses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.22799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.72799683 42.92200089 Tm [(SUMO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(-sp)1(e)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.85100174 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.35100174 58.52199936 Tm [(pro)1(teases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.29599762 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79599762 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.56300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.06300354 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.20400238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.70400238 58.52199936 Tm [(SENP7,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.11399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.61399841 58.52199936 Tm [(pro)1(c)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.97200012 58.52199936 Tm [(SUMO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.01400757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.51400757 58.52199936 Tm [(precu)-1(r)1(sors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.79098511 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 74.12200165 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.96099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.46099854 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.43600082 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.93599701 74.12200165 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.48999786 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.98999786 74.12200165 Tm [(dig)1(l)-1(ycin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.61799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.11799622 74.12200165 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.14100647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.64100647 74.12200165 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.18200684 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.68200684 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.96000671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.46000671 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.46099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.96099854 74.12200165 Tm [(conj)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ugat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.29299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.79299927 89.72200012 Tm [(reaction.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.0059967 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 0.75 m 137.55000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 17.10000038 m 137.55000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 33.45000076 m 137.55000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 49.80000305 m 137.55000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 66.15000153 m 137.55000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 82.5 m 137.55000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.55000305 98.84999847 m 137.55000305 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 192.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.82499695 m 426.92498779 192.82499695 l S Q Q q 1 0 0 1 0 576.32897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>