%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 97.5 l -90 97.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 86.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 255.6000061 0 0 -85.30000305 0 85.30000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 140.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.55799866 23.67700005 Tm 0 g [(SE)1(NP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03799438 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.03799438 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.74200439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SE)-1(N)1(P2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.47499847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.72499847 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.7250061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SE)-1(N)1(P2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.47499847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.84899902 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.0510025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.42500305 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.40499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.77900696 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.25300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SUMO1/sentrin)-1(/SMT)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.11500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.48899841 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.24000549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.61399841 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.67599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.05000305 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.18099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.55499268 12.82499981 Tm [(AXA)1(M2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.26400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.63800049 12.82499981 Tm [(SMT)-1(3IP)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.26998901 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(189)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SE)-1(N)1(P2)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 281.43099976 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SUMO1/se)-1(nt)1(rin)-1(/SMT3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.98300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.48300171 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.44000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.94000244 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.29400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.79400635 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.07200623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AXA)1(M2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.70800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.20800018 11.72200012 Tm [(SMT3)-1(IP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.06199646 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(C62)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.14899826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(40)-1(60)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 155.17500305 31.95000076 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 155.17500305 78.75 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 272.375 -0.25 l 272.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SUMO1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.81900024 11.72200012 Tm [(\(UBL1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.2539978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.7539978 11.72200012 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.98600006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.48600006 11.72200012 Tm [(60)-1(19)-1(12)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.15899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.65899658 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.22000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.72000122 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.69500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.19500732 11.72200012 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55900574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.05900574 11.72200012 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.42999268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.92999268 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.76900101 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26900101 27.3220005 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3030014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8030014 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.65699768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.15699768 27.3220005 Tm [(covalen)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.65000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15000153 27.3220005 Tm [(conj)-1(ug)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.82800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.32800293 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.40299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.90299988 27.3220005 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.06199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.56199646 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.20100403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.70098877 27.3220005 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ENP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.04899979 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.54899979 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.11000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61000061 42.92200089 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.98400116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.48400116 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.3259964 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.8259964 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.8010025 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.3010025 42.92200089 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51000214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.01000214 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.85199738 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.35199738 42.92200089 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.89900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.39900208 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.6210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.1210022 42.92200089 Tm [(pro)1(c)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.97900391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.47900391 42.92200089 Tm [(ne)-1(w)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.39599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.89599609 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(yn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.65999985 58.52199936 Tm [(SUMO1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.97899628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47899628 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.49500275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.99500275 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.9960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.4960022 58.52199936 Tm [(conj)-1(ug)1(ata)1(ble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.53500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.03500366 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.7460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.2460022 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.522995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.022995 58.52199936 Tm [(cata)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.53199959 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.03199959 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.03300095 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.53300095 74.12200165 Tm [(deconj)-1(ug)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.87400055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.37400055 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.21600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.71600342 74.12200165 Tm [(SUMO1-conta)1(i)-1(ning)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.67599487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.17599487 74.12200165 Tm [(speci)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.54400635 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 0.75 m 154.80000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 17.10000038 m 154.80000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 33.45000076 m 154.80000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 49.80000305 m 154.80000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 66.15000153 m 154.80000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 98.1000061 m 154.80000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 114.45000458 m 154.80000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 130.80000305 m 154.80000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm 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