%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.04000092 23.67700005 Tm 0 g [(SDF4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.55499268 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.55499268 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.25900269 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(SD)-1(F4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.43099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.68099976 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.68099976 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SD)-1(F4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.43099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.80500031 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.00700378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.3809967 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.36099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.73500061 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.20899963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(stromal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.64800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.02200317 12.82499981 Tm [(ce)1(l)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.5059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.87999725 12.82499981 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.17500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.54899597 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.93800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.31199646 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.44299316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.81700134 12.82499981 Tm [(Cab)-1(4)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.41499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.78900146 12.82499981 Tm [(SD)-1(F-4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.43400574 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(312)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(SD)-1(F4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.25 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.47999954 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.97999954 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.38999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.88999939 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.17199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.67199707 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.79100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.29100037 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cab)1(4)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.46500015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.96500015 11.72200012 Tm [(SDF-4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.96699905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9B)-1(RK)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.125 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(06)-1(21)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 139.42500305 78.75 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 288.125 -0.25 l 288.125 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.6499939 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.05999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.55999756 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.84199524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.34199524 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.46099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.96099854 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.18299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.68299866 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.2440033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.7440033 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.71899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.21899414 11.72200012 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72400093 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22400093 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.06600189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.56600189 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.56700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.06700134 27.3220005 Tm [(CREC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.93199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.43199921 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.23899841 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.98699951 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.79400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.29400635 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.80099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.30099487 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.60800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.10800171 27.3220005 Tm [(contai)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 42.92200089 Tm [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.33499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.83499908 42.92200089 Tm [(EF-h)1(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.27700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.77700043 42.92200089 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46600342 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.74299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.24299622 42.92200089 Tm [(calc)-1(ium-b)1(i)-1(nd)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.05000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.55000305 42.92200089 Tm [(mot)1(ifs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.90499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.40499878 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.66700745 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.16700745 42.92200089 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.13800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.63800049 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.71300125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.21299744 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.21399689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.71399689 58.52199936 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.67500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.17500305 58.52199936 Tm [(lume)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20100403 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.70100403 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.97799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47799683 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.64900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.14900208 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.00300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.50300598 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.87199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.37199402 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.31300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.81300354 58.52199936 Tm [(regul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.02499962 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.52499962 74.12200165 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.29499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.79499817 74.12200165 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.82099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.32099915 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.08299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.58299255 74.12200165 Tm [(activit)1(i)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.125 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 0.75 m 139.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 17.10000038 m 139.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 33.45000076 m 139.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 49.80000305 m 139.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 66.15000153 m 139.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 82.5 m 139.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 98.84999847 m 139.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 115.19999695 m 139.05000305 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 577.07897949 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>