%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.84999847 23.67700005 Tm 0 g [(RND3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.7460022 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.7460022 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.45001221 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RN)1(D)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.26100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 92.51100159 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.51100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RN)1(D)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.26100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.63500214 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.83699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.21099854 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.19099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.56500244 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.03900146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.75499725 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.1289978 12.82499981 Tm [(famil)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.32299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.6969986 12.82499981 Tm [(GTPase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.2230072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.59700012 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.102005 12.82499981 Tm [(ARHE;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.35699463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.73100281 12.82499981 Tm [(Rho)-1(8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.61700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.99099731 12.82499981 Tm [(Rho)-1(E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.68200684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.05599976 12.82499981 Tm [(me)1(mB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-244)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(RN)1(D)-1(3)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 327.47698975 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Rho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.13899994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63899994 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.72100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.22100067 11.72200012 Tm [(GTPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.8259964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.3259964 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.60399628 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AR)1(H)-1(E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.2840004 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.7840004 11.72200012 Tm [(Rho)1(8)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.36700058 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.86700058 11.72200012 Tm [(Rho)1(E;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.12000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.62000275 11.72200012 Tm [(memB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.23999786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P61)-1(58)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(12)-1(51)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 136.7749939 16.35000038 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 136.0249939 0.75 l 136.0249939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 137.0249939 -0.25 l 137.0249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 136.7749939 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 136.7749939 94.34999847 l h f* Q q 1 0 0 1 136.3999939 0 cm -0.625 -0.25 m 290.7749939 -0.25 l 290.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.57400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.07400513 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.63499451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.13499451 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.61000061 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.87399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.37399292 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.21600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.71600342 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.71699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.2170105 11.72200012 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GTPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.60499954 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.10499954 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.41200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.91200256 27.3220005 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.16300201 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.66299438 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.47000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.97000122 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.477005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.977005 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.28399658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.78399658 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.39599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.89599609 27.3220005 Tm [(only)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.32199097 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(GTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.3579998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.8579998 42.92200089 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.50500107 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.00500107 42.92200089 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.68700027 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.18700027 42.92200089 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.45500183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.95500183 42.92200089 Tm [(GTPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.55999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.05999756 42.92200089 Tm [(activit)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.69799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.19799805 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.4750061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.9750061 42.92200089 Tm [(ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.1289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.6289978 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.70399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.20399475 42.92200089 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.04499817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.54499817 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.68600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.18600464 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.16101074 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.66101074 42.92200089 Tm [(ne)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.5529995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.0529995 58.52199936 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.77999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.27999878 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.12200165 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.62200165 58.52199936 Tm [(cy)-1(t)1(oske)-1(letal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.36999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.86999512 58.52199936 Tm [(org)1(anizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.11599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.61599731 58.52199936 Tm [(leading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.54699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.04699707 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.12199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.62199402 58.52199936 Tm [(loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.0710144 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.5710144 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.41299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ad)1(hesion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.875 74.12200165 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.60700226 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.10700226 74.12200165 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.63000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.13000488 74.12200165 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.21099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.71099854 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.94700623 74.12200165 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.28900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.78900146 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.79000854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.68000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.18000031 89.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.65299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.15299988 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.50700378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.00700378 89.72200012 Tm [(identified.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10400391 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 0.75 m 136.3999939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 17.10000038 m 136.3999939 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 33.45000076 m 136.3999939 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 49.80000305 m 136.3999939 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 66.15000153 m 136.3999939 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 82.5 m 136.3999939 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 98.84999847 m 136.3999939 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 136.3999939 115.19999695 m 136.3999939 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>