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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.65699768 23.67700005 Tm 0 g [(RHEB)1(L1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 156.93800354 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 333.64199829 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RHEBL)-1(1)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 95.81800079 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.06800079 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 185.06799316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RHEBL)-1(1)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 95.81800079 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 98.19200134 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 131.39399719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 133.76800537 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 193.7480011 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 196.12199402 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 230.59599304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Ras)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 77.83699799 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 80.21099854 12.82499981 Tm [(ho)-1(molo)-1(g)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 118.07900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 120.45300293 12.82499981 Tm [(enriched)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 157.96200562 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 160.33599854 12.82499981 Tm [(in)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 168.26199341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 170.63600159 12.82499981 Tm [(brai)-1(n)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 192.76899719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 195.14300537 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 209.96000671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 212.33399963 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 220.46499634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 222.83900452 12.82499981 Tm [(RHEBL)-1(1)1(c)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 260.09698486 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <</MCID 53 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 19.43899918 l -0.75 19.43899918 l h W n q /GS2 gs 1 g 3.95000005 0.5 m 422.15002441 0.5 l 422.15002441 18.43899918 l 3.95000005 18.43899918 l h f* Q q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 57 >> BDC q /GS2 gs 1 g 0 1.25 m 28.15600014 1.25 l 28.15600014 16.68799973 l 0 16.68799973 l h f* Q q /GS2 gs 1 g 28.15600014 1.25 m 30.81900024 1.25 l 30.81900024 16.68799973 l 28.15600014 16.68799973 l h f* Q q /GS2 gs 1 g 30.81900024 1.25 m 62.12599945 1.25 l 62.12599945 16.68799973 l 30.81900024 16.68799973 l h f* Q q /GS2 gs 1 g 62.12599945 1.25 m 64.78900146 1.25 l 64.78900146 16.68799973 l 62.12599945 16.68799973 l h f* Q q /GS2 gs 1 g 64.78900146 1.25 m 127.63999939 1.25 l 127.63999939 16.68799973 l 64.78900146 16.68799973 l h f* Q q /GS2 gs 1 g 127.63999939 1.25 m 130.30299377 1.25 l 130.30299377 16.68799973 l 127.63999939 16.68799973 l h f* Q q /GS2 gs 1 g 130.30299377 1.25 m 139.37799072 1.25 l 139.37799072 16.68799973 l 130.30299377 16.68799973 l h f* Q q /GS2 gs 1 g 139.37800598 1.25 m 142.04100037 1.25 l 142.04100037 16.68799973 l 139.37800598 16.68799973 l h f* Q q /GS2 gs 1 g 142.04100037 1.25 m 149.35800171 1.25 l 149.35800171 16.68799973 l 142.04100037 16.68799973 l h f* Q q /GS2 gs 1 g 149.35800171 1.25 m 152.02099609 1.25 l 152.02099609 16.68799973 l 149.35800171 16.68799973 l h f* Q q /GS2 gs 1 g 152.02099609 1.25 m 187.66099548 1.25 l 187.66099548 16.68799973 l 152.02099609 16.68799973 l h f* Q q /GS2 gs 1 g 187.66099548 1.25 m 190.32398987 1.25 l 190.32398987 16.68799973 l 187.66099548 16.68799973 l h f* Q q /GS2 gs 1 g 190.32400513 1.25 m 206.15701294 1.25 l 206.15701294 16.68799973 l 190.32400513 16.68799973 l h f* Q q /GS2 gs 1 g 206.15699768 1.25 m 208.81999207 1.25 l 208.81999207 16.68799973 l 206.15699768 16.68799973 l h f* Q q /GS2 gs 1 g 208.82000732 1.25 m 235.89001465 1.25 l 235.89001465 16.68799973 l 208.82000732 16.68799973 l h f* Q q /GS2 gs 1 g 235.88999939 1.25 m 238.55299377 1.25 l 238.55299377 16.68799973 l 235.88999939 16.68799973 l h f* Q q /GS2 gs 1 g 238.55299377 1.25 m 260.35900879 1.25 l 260.35900879 16.68799973 l 238.55299377 16.68799973 l h f* Q q /GS2 gs 1 g 260.35900879 1.25 m 263.02200317 1.25 l 263.02200317 16.68799973 l 260.35900879 16.68799973 l h f* Q q /GS2 gs 1 g 263.02200317 1.25 m 271.86401367 1.25 l 271.86401367 16.68799973 l 263.02200317 16.68799973 l h f* Q q /GS2 gs 1 g 271.86401367 1.25 m 274.52700806 1.25 l 274.52700806 16.68799973 l 271.86401367 16.68799973 l h f* Q q /GS2 gs 1 g 274.52700806 1.25 m 304.56799316 1.25 l 304.56799316 16.68799973 l 274.52700806 16.68799973 l h f* Q q /GS2 gs 1 g 304.56799316 1.25 m 307.23098755 1.25 l 307.23098755 16.68799973 l 304.56799316 16.68799973 l h f* Q q /GS2 gs 1 g 307.23098755 1.25 m 340.55899048 1.25 l 340.55899048 16.68799973 l 307.23098755 16.68799973 l h f* Q EMC /P <</MCID 58 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 12.89099979 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 28.15600014 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 30.81900024 12.89099979 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 62.12599945 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 64.78900146 12.89099979 Tm [(correspond)1(i)-1(ng)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 127.63999939 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 130.30299377 12.89099979 Tm [(to)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 139.37800598 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 142.04100037 12.89099979 Tm [(N)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 149.35800171 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 152.02099609 12.89099979 Tm [(terminal)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 187.66099548 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 190.32400513 12.89099979 Tm [(15)-1(0)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 206.15699768 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 208.82000732 12.89099979 Tm [(amino)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 235.88999939 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 238.55299377 12.89099979 Tm [(acids)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 260.35900879 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 263.02200317 12.89099979 Tm [(of)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 271.86401367 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 274.52700806 12.89099979 Tm [(human)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 304.56799316 12.89099979 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 307.23098755 12.89099979 Tm [(RHEB)-1(L1)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 340.55899048 12.89099979 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 18.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 18.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 18.68899918 m 426.3500061 18.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 292.57299805 m 416.75 292.57299805 l 416.75 323.77301025 l -1.45000005 323.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 323.77301025 m 416.75 323.77301025 l 416.75 354.97302246 l -1.45000005 354.97302246 l h f* Q q 1 0 0 1 0 292.57299805 cm /P <</MCID 82 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 354.97299194 cm /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 382.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ras)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 15.01599979 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 19.51600075 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 58.80799866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 63.30799866 11.72200012 Tm [(en)-1(r)1(i)-1(ched)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 100.70999908 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 105.20999908 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 113.15100098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 117.65100098 11.72200012 Tm [(bra)1(in)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 139.75100708 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 144.25100708 11.72200012 Tm [(lik)-1(e)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 159.04699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 163.54699707 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 168.82499695 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 105 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RHEB)-1(L1c)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 37.8409996 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 110 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8T)-1(A)1(I7)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 32.02700043 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 113 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 116 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 117 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(27)-1(48)-1(2)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 119 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 137 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 140 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 141 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 145 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 146 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 123.27500153 16.35000038 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 147 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 122.52500153 0.75 l 122.52500153 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 123.52500153 -0.25 l 123.52500153 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 160 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 123.27500153 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 123.27500153 125.55000305 l h f* Q q 1 0 0 1 122.90000153 0 cm -0.625 -0.25 m 300.5249939 -0.25 l 300.5249939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RhebL1)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 32.16799927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 36.66799927 11.72200012 Tm [(\(ras)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 52.25099945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 56.75099945 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 96.04299927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 100.54299927 11.72200012 Tm [(en)-1(r)1(i)-1(ched)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 137.94500732 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 142.44500732 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 150.38600159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 154.88600159 11.72200012 Tm [(bra)1(in)-1(-)1(lik)-1(e)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 195.67599487 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 200.17599487 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 231.48300171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 235.98300171 11.72200012 Tm [(1\),)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 246.43299866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 250.93299866 11.72200012 Tm [(also)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 268.19000244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 272.69000244 11.72200012 Tm [(kn)-1(o)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(wn)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 12.65200043 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 17.15200043 27.3220005 Tm [(as)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 26.29299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 30.79299927 27.3220005 Tm [(Rheb2)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 58.34199905 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 62.84199905 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 72 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 76.5 27.3220005 Tm [(GTPa)1(se)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 108.10500336 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 112.60500336 27.3220005 Tm [(RhebL1,)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 146.93899536 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 151.43899536 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 158 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 162.5 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 167.4750061 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 171.9750061 27.3220005 Tm [(18)-1(3)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 187.80799866 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 192.30799866 27.3220005 Tm [(amino)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 219.37800598 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 223.87800598 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 241.51800537 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 246.01800537 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 277.32501221 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 281.82501221 27.3220005 Tm [(th)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 8.32800007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 12.82800007 42.92200089 Tm [(belongs)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 47.26800156 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 51.76800156 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 60.8429985 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 65.34300232 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 79.34400177 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 83.84400177 42.92200089 Tm [(small)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 106.20800018 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 110.70800018 42.92200089 Tm [(GTPa)1(se)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 142.31300354 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 146.81300354 42.92200089 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 196.89700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 201.39700317 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 217.67399597 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 222.17399597 42.92200089 Tm [(Rheb)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 244.44500732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 248.94500732 42.92200089 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 277.19299316 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 281.69299316 42.92200089 Tm [(Lo)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(calizing)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 32.40100098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 36.90100098 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 45.97600174 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 50.47600174 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 64.47699738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 68.97699738 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 83.38700104 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 87.88700104 58.52199936 Tm [(membrane)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 134.67100525 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 139.17100525 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 148.31199646 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 152.81199646 58.52199936 Tm [(well)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 169.81399536 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 174.31399536 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 183.45500183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 187.95500183 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 201.95599365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 206.45599365 58.52199936 Tm [(cy)-1(t)1(oplas)1(m,)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 252.69099426 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 257.19100952 58.52199936 Tm [(RhebL1)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 289.35900879 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 6.56099987 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 11.06099987 74.12200165 Tm [(ubiquito)1(usly)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 64.39299774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 68.89299774 74.12200165 Tm [(expressed)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 112.04699707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 116.54699707 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 132.82400513 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 137.32400513 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 143.88499451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 148.38499451 74.12200165 Tm [(inc)-1(reased)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 189.38600159 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 193.88600159 74.12200165 Tm [(tw)1(o-)1(fold)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 230.95399475 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 235.45399475 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 243.39500427 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 247.89500427 74.12200165 Tm [(many)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 271.61199951 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 276.11199951 74.12200165 Tm [(tu)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mor)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 17.5909996 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 22.0909996 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 36.50099945 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 41.00099945 89.72200012 Tm [(line)-1(s.)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 62.77600098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 67.27600098 89.72200012 Tm [(RhebL1)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 99.44400024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 103.94400024 89.72200012 Tm [(exhibit)1(s)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 137.21099854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 141.71099854 89.72200012 Tm [(GTPa)1(se)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 173.31599426 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 177.81599426 89.72200012 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 208.28799438 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 212.78799438 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 229.06500244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 233.56500244 89.72200012 Tm [(may)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 251.73599243 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 256.23599243 89.72200012 Tm [(activat)1(e)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 289.63000488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(NF-kapp)1(a-B-mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 96.65299988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 101.15299988 105.3219986 Tm [(gene)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 122.66899872 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 127.16899872 105.3219986 Tm [(tr)1(ansc)-1(rip)1(tion.)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 183.91999817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 188.41999817 105.3219986 Tm [(Regulat)1(i)-1(ng)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 235.125 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 239.625 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 253.62600708 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 258.12600708 105.3219986 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 288.59799194 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 8.84200001 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 13.34200001 120.92199707 Tm [(Rictor,)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 40.8030014 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 45.3030014 120.92199707 Tm [(RhebL1)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 77.47100067 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 81.97100067 120.92199707 Tm [(also)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 99.22799683 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 103.72799683 120.92199707 Tm [(pro)1(motes)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 145.41499329 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 149.91499329 120.92199707 Tm [(signal)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 175.147995 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 179.647995 120.92199707 Tm [(tr)1(ansduc)-1(t)1(ion.)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 236.12199402 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 240.62199402 120.92199707 Tm [(RhebL1)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 272.79000854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 277.29000854 120.92199707 Tm [(exi)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 0.75 m 122.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 17.10000038 m 122.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 33.45000076 m 122.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 49.80000305 m 122.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 66.15000153 m 122.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 82.5 m 122.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 98.84999847 m 122.90000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.90000153 115.19999695 m 122.90000153 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 423.17498779 240.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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