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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.85600281 23.67700005 Tm 0 g [(RFFL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.74000549 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 145.74000549 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 322.44400024 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RFF)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.76399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 88.01399994 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 172.01400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RFF)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.76399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.13800049 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.33999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.71399689 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.69400024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.06799316 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.54200745 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.52899933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.5719986 12.82499981 Tm [(fi)-1(nge)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.57299805 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.63600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.67900085 12.82499981 Tm [(FY)-1(VE-)-1(li)-1(k)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.73599243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.77900696 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.17599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.21899414 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.0539856 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.09698486 12.82499981 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.54598999 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.58898926 12.82499981 Tm [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.91799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.96099854 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.34298706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 353.38598633 12.82499981 Tm [(li)-1(gase)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.31799316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 384.36099243 12.82499981 Tm [(CARP)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29199219 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(FRING;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.38299942 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.75699997 30.49699783 Tm [(CARP)1(-)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90299988 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.27700043 30.49699783 Tm [(RN)1(F)-1(189)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.35500336 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.72899628 30.49699783 Tm [(RN)1(F)-1(34L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.8999939 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.27400208 30.49699783 Tm [(RIFIF)-1(YL)-1(I)1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.8690033 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(97-31)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(RFF)-1(L)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 328.18499756 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 145.7749939 31.95000076 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.13400078 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63400078 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.99499893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.49499893 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.27200317 11.72200012 Tm [(FYVE-)1(l)-1(ike)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.20999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.70999908 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.53700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.03700256 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.78399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.28399658 11.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.50999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.00999451 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.69100952 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.19100952 11.72200012 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 27.3220005 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.41600037 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CAR)1(P2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.67900085 11.72200012 Tm [(FRING;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.15799713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.65799713 11.72200012 Tm [(CAR)1(P-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.73100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23100281 11.72200012 Tm [(RNF18)-1(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.20500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.70500183 11.72200012 Tm [(RNF34)-1(L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.51899719 11.72200012 Tm [(RIFIFYLIN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.26100159 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WZ73)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.9070015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(28)-1(42)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 145.7749939 78.75 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 281.7749939 -0.25 l 281.7749939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22599983 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.72599983 11.72200012 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.60700226 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.10700226 11.72200012 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.90100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40100098 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.6230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1230011 11.72200012 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.96400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.46400452 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.3730011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.8730011 11.72200012 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.88900757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.13000107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.63000107 27.3220005 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.52700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02700043 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.02799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.52799988 27.3220005 Tm [(ubiquitin-)1(me)-1(dia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.98500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.48500061 27.3220005 Tm [(pro)1(teasoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.51600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.01600647 27.3220005 Tm [(degr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ad)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.72200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.22200012 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.06399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.56399918 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.52799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02799988 42.92200089 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.00800323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.50800323 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.14700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.64700317 42.92200089 Tm [(Mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.29899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.79899597 42.92200089 Tm [('L)-1(ys-)1(4)-1(8')-1(-)1(lin)-1(ked)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.40301514 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.2990036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.7990036 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.64099884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.14099884 58.52199936 Tm [(PRR)1(5)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.29499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.79499817 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.07200623 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.57200623 58.52199936 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.48599243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.98599243 58.52199936 Tm [(subsequen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.0269928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.5269928 58.52199936 Tm [(pro)1(teasoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.55801392 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.77799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.27799988 74.12200165 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.83399963 74.12200165 Tm [(indirec)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.49499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.99499512 74.12200165 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.26100159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.76100159 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.17100525 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.67100525 74.12200165 Tm [(migra)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.68299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.18299866 74.12200165 Tm [(th)1(ro)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 0.75 m 145.3999939 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 32.70000076 m 145.3999939 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 49.05000305 m 145.3999939 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 65.40000153 m 145.3999939 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 81.75 m 145.3999939 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 98.09999847 m 145.3999939 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 114.44999695 m 145.3999939 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 130.80000305 m 145.3999939 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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