%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.09999847 23.67700005 Tm 0 g [(DLAT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.49499512 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.49499512 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.19900513 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(DL)-1(A)1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.06600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 90.31600189 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.31599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DL)-1(A)1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.06600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.44000244 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.64199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.01599884 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.9960022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.36999512 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.84399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(di)-1(hydrol)-1(ip)-1(oamid)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.35099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.7250061 12.82499981 Tm [(S-)-1(ac)1(etyltransferase)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.227005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.60099792 12.82499981 Tm [(DL)-1(TA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.477005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.85099792 12.82499981 Tm [(PDCE2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.5920105 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.96600342 12.82499981 Tm [(PDC-E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.11199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(DL)-1(A)1(T)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.79501343 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(dih)1(y)-1(d)1(rolipoa)1(mi)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.29799652 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.79799652 11.72200012 Tm [(S-a)1(c)-1(etyltra)1(n)-1(sf)1(e)-1(r)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.37800598 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DLTA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.13199997 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.63199997 11.72200012 Tm [(PDC)1(E2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.4070015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.90699768 11.72200012 Tm [(PDC)1(-E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.40899658 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P10)-1(51)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(39)-1(08)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 167.67500305 31.95000076 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(PA)1(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47999954 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 167.67500305 16.35000038 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 166.92500305 0.75 l 166.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 167.92500305 -0.25 l 167.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.67500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 167.67500305 94.34999847 l h f* Q q 1 0 0 1 167.30000305 0 cm -0.625 -0.25 m 259.875 -0.25 l 259.875 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.88400269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.38400269 11.72200012 Tm [(E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.61000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.11000061 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.95199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.45199585 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.45300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.95300293 11.72200012 Tm [(multi-enzyme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.34899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pyruvat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.65200043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.15200043 27.3220005 Tm [(dehydro)1(gen)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.89199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.39199829 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.8710022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.3710022 27.3220005 Tm [(\(PDC)1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.93200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.43200684 27.3220005 Tm [(PDC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.81399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.31399536 27.3220005 Tm [(resides)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.44700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.94700623 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 42.92200089 Tm [(inn)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.53099823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.03099823 42.92200089 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.21399689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71399689 42.92200089 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.4980011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.9980011 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.2749939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7749939 42.92200089 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.44700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.94700623 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.94799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.44799805 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(onversion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86299896 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.70500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.20500183 58.52199936 Tm [(pyruvat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.85700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35700226 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.43199921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.93199921 58.52199936 Tm [(ace)-1(t)1(yl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.03799438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.53799438 58.52199936 Tm [(coe)-1(nz)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.15400696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.65400696 58.52199936 Tm [(A.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.15299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.65299988 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.96000671 58.52199936 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 74.12200165 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.51599884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.01599884 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.85800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.35800171 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.81400299 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.31400299 74.12200165 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.9960022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.4960022 74.12200165 Tm [(dih)1(y)-1(d)1(rolipoa)1(mi)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.79400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.29400635 74.12200165 Tm [(ace)-1(t)1(yl)-1(t)1(ransf)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.41399956 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.91399956 89.72200012 Tm [(acc)-1(ept)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.28900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.78900146 89.72200012 Tm [(ace)-1(t)1(yl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.89499664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.39499664 89.72200012 Tm [(gr)1(oups)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.76999664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.26999664 89.72200012 Tm [(fo)1(rme)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.84500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34500122 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.85699463 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.35699463 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.35800171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.85800171 89.72200012 Tm [(oxid)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.84599304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.34599304 89.72200012 Tm [(dec)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 0.75 m 167.30000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 17.10000038 m 167.30000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 33.45000076 m 167.30000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 49.80000305 m 167.30000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 66.15000153 m 167.30000305 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 98.1000061 m 167.30000305 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 114.45000458 m 167.30000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.30000305 130.80000305 m 167.30000305 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>