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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.75900269 23.67700005 Tm 0 g [(DHC)-1(R2)1(4)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 150.83700562 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 161.83700562 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 338.54098511 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(DHCR24)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 97.94499969 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.19499969 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 187.19500732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DHCR24)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 97.94499969 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 100.31900024 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 133.52099609 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 135.89500427 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 195.875 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 198.24899292 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 232.7230072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(24-dehydrocho)-1(leste)1(rol)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 160.16600037 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 162.53999329 12.82499981 Tm [(re)1(d)-1(uctase)1(;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 207.58500671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 209.95899963 12.82499981 Tm [(DCE)-1(;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 229.95399475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 232.32800293 12.82499981 Tm [(SE)-1(LADIN)1(1;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 276.78399658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 279.1579895 12.82499981 Tm [(Nbla03646;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 328.30999756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 330.68399048 12.82499981 Tm [(selad)-1(in-)-1(1)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 369.43399048 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <</MCID 51 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 52 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(217)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(DHCR24)] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAABB 9 Tf 1 0 0 -1 287.83401489 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <</MCID 76 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <</MCID 79 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(24)-1(-)1(de)-1(h)1(y)-1(d)1(rocholesterol)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 97.98899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 102.48899841 11.72200012 Tm [(reduc)-1(t)1(ase)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 144.44799805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DCE)1(;)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 19.99099922 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 24.49099922 11.72200012 Tm [(SELAD)1(IN1)-1(;)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 69.84700012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 74.34700012 11.72200012 Tm [(Nbla036)-1(46)-1(;)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 123.33699799 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 127.83699799 11.72200012 Tm [(seladin-1)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 167.3480072 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q15)-1(39)-1(2)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 105 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(04)-1(37)-1(5)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 109 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 181.32499695 31.95000076 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SD)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(S-PA)1(GE)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 32.56800079 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 136 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 181.32499695 16.35000038 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 137 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 180.57499695 0.75 l 180.57499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 181.57499695 -0.25 l 181.57499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 149 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 150 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 181.32499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 181.32499695 94.34999847 l h f* Q q 1 0 0 1 180.94999695 0 cm -0.625 -0.25 m 246.2250061 -0.25 l 246.2250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 151 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(flav)1(i)-1(n)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 120.82499695 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 125.32499695 11.72200012 Tm [(ad)1(e)-1(nine)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 159.7559967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 164.2559967 11.72200012 Tm [(dinuc)-1(leot)1(i)-1(d)1(e)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 217.84700012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 222.34700012 11.72200012 Tm [(\(FA)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(D\)-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 60.78099823 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 65.28099823 27.3220005 Tm [(oxid)1(oreduc)-1(t)1(ase)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 131.39700317 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 135.89700317 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 160.9940033 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 165.4940033 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 204.16600037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 208.66600037 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 222.66700745 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 227.16700745 27.3220005 Tm [(re)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(duction)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 32.83200073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 37.33200073 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 46.17399979 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 50.67399979 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 64.67500305 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 69.17500305 42.92200089 Tm [(delta)1(-24)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 105.20999908 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 109.70999908 42.92200089 Tm [(do)1(u)-1(b)1(le)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 139.98399353 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 144.48399353 42.92200089 Tm [(bo)1(n)-1(d)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 167.2559967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 171.7559967 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 180.5980072 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 185.0980072 42.92200089 Tm [(st)1(e)-1(ro)1(l)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 209.2769928 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 213.7769928 42.92200089 Tm [(inter)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 39.29199982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 43.79199982 58.52199936 Tm [(during)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 72.22899628 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 76.72899628 58.52199936 Tm [(cholesterol)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 124.18599701 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 128.68600464 58.52199936 Tm [(bios)1(y)-1(nt)1(he)-1(s)1(i)-1(s)1(.)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 183.92100525 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 188.42100525 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 204.22799683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 208.72799683 58.52199936 Tm [(pro)1(tei)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(contains)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 46.26100159 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 50.76100159 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 55.73600006 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 60.23600006 74.12200165 Tm [(leader)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 87.01200104 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 91.51200104 74.12200165 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 132.35899353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 136.85899353 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 154.08099365 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 158.58099365 74.12200165 Tm [(directs)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 187.30799866 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 191.80799866 74.12200165 Tm [(it)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 197.55599976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 202.05599976 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 211.1309967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 215.6309967 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 229.63200378 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 54.75600052 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 59.25600052 89.72200012 Tm [(reticu)-1(lum)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 99.98000336 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 104.48000336 89.72200012 Tm [(membrane.)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 153.43099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 157.93099976 89.72200012 Tm [(Missen)-1(s)1(e)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 197.37600708 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 201.87600708 89.72200012 Tm [(mutat)1(io)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 0.75 m 180.94999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 17.10000038 m 180.94999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 33.45000076 m 180.94999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 49.80000305 m 180.94999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 66.15000153 m 180.94999695 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 98.1000061 m 180.94999695 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 114.45000458 m 180.94999695 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.94999695 130.80000305 m 180.94999695 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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