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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.16999817 23.67700005 Tm 0 g [(RTCB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.42500305 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 148.42500305 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.1289978 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(RTCB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.12799835 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.12800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(RTCB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.87799835 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.2519989 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.45400238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.82800293 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.80799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.18200684 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.65600586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(RN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.30400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.6780014 12.82499981 Tm [(2',)1(3'-cy)1(cl)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.05699921 12.82499981 Tm [(ph)-1(osp)-1(hate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.53799438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.91200256 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.9750061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.34899902 12.82499981 Tm [(5'-OH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.69700623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.07099915 12.82499981 Tm [(li)-1(gase)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.00300598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.3769989 12.82499981 Tm [(FAAP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.58599854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.95999146 12.82499981 Tm [(HS)-1(P)1(C117;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.12399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.49798584 12.82499981 Tm [(C22orf28;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.59500122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.96899414 12.82499981 Tm [(DJ149A)1(16.6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 413.43399048 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 48.70299911 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 48.70299911 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 66.375 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 84.58099365 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 84.58099365 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 252.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 35.03900146 l -0.75 35.03900146 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(306-5)1(05)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(RTCB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.77301025 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 34.03900146 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 34.03900146 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 34.28900146 m 426.3500061 34.28900146 l S Q Q q /GS2 gs 1 g -1.45000005 287.25100708 m 416.75 287.25100708 l 416.75 318.45101929 l -1.45000005 318.45101929 l h f* Q q 1 0 0 1 0 287.25100708 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 318.45098877 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52499962 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02499962 11.72200012 Tm [(2')-1(,)1(3)-1('-cy)-1(clic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.34799957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.84799957 11.72200012 Tm [(ph)1(osph)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.74900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.24900055 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.02600098 11.72200012 Tm [(5')-1(-)1(OH)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.30000305 11.72200012 Tm [(ligas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.09399414 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FAA)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.11899948 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.61899948 11.72200012 Tm [(HS)-1(P)1(C1)-1(17)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.3010025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.8010025 11.72200012 Tm [(C22)-1(or)1(f28)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.87799835 11.72200012 Tm [(DJ14)-1(9A16.6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.46299744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y3I0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.24500084 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(02)-1(97)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.22499847 16.35000038 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 116.47499847 0.75 l 116.47499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 117.47499847 -0.25 l 117.47499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.22499847 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 117.22499847 94.34999847 l h f* Q q 1 0 0 1 116.84999847 0 cm -0.625 -0.25 m 310.32501221 -0.25 l 310.32501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cat)1(alytic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.74300003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.24300003 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.54299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.04299927 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.88500214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.38500214 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.38600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.88600159 11.72200012 Tm [(tR)1(NA-s)1(plic)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.57299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.07299805 11.72200012 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.86700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.36700439 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.84599304 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.34599304 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.56799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.06799316 11.72200012 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.07501221 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.57501221 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.08700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.71999931 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.22000122 27.3220005 Tm [(joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.48400116 27.3220005 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.56500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.06500244 27.3220005 Tm [(tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.94300079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44299316 27.3220005 Tm [(ha)1(l)-1(v)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.35099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.85099792 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.92599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.42599487 27.3220005 Tm [(mat)1(u)-1(r)1(e)-1(-)1(sized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.01899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.51899719 27.3220005 Tm [(tR)1(NAs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.56298828 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.06298828 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.57501221 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.07501221 27.3220005 Tm [(inc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(orp)1(orat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.09000015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.59000015 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.59100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.09100342 42.92200089 Tm [(precu)-1(r)1(sor-)1(de)-1(r)1(ive)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.37800598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.87800598 42.92200089 Tm [(splice)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.20199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.70199585 42.92200089 Tm [(jun)-1(ctio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.22599792 42.92200089 Tm [(ph)1(osph)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.12701416 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.62701416 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.14300537 42.92200089 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.45600128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.95600128 58.52199936 Tm [(tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.83399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.33399963 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.97499847 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.44999695 58.52199936 Tm [(canonic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.02900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.52900696 58.52199936 Tm [(3')-1(,)1(5)-1('-ph)1(osph)1(odiester.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.43400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.93400574 58.52199936 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.46600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.96600342 58.52199936 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.80700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.30700684 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.44799805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.94799805 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.46899414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52499962 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.02499962 74.12200165 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31900024 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.71499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.21499634 74.12200165 Tm [(bro)1(ad)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.85299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.35299683 74.12200165 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.20300293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.70300293 74.12200165 Tm [(speci)-1(f)1(ic)-1(it)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.33799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.83799744 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.11500549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.61500549 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.78599548 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.28599548 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.02700806 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52700806 74.12200165 Tm [(to)1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ard)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.16800022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.66799927 89.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.82699966 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.32699966 89.72200012 Tm [(RNA)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.18399811 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 0.75 m 116.84999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 17.10000038 m 116.84999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 33.45000076 m 116.84999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 49.80000305 m 116.84999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 66.15000153 m 116.84999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 82.5 m 116.84999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 98.84999847 m 116.84999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.84999847 115.19999695 m 116.84999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92501831 209.17498779 l S Q Q q 1 0 0 1 0 528.00097656 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 561.53997803 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 589.47900391 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm
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