%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 130 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 44 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(ZSCAN2)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 159.94700623 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 270.38699341 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.38699341 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(ZS)-1(CAN)1(21)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 136.14700317 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.64700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.89700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ZSC)-1(A)1(N21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.94400024 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.08999634 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.41099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.78500366 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.58099365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NY-REN-21;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.38300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.75700378 12.82499981 Tm [(Zi)-1(pro1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.92900085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.30299377 12.82499981 Tm [(ZNF38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.46600342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZS)-1(CAN)1(21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.83699799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.44799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.82200623 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.44200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.81599426 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.17799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 143.17500305 203.55000305 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Zinc)-1(-f)1(in)-1(g)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.29000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79000092 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.26300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76300049 11.72200012 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.81199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.31199646 11.72200012 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.85400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.35400391 11.72200012 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.84700012 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.12399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.62399292 11.72200012 Tm [(ha)1(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.58100033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.08099937 27.3220005 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.44499969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.94499969 27.3220005 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.19799805 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.04000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.54000092 27.3220005 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.61300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.11300659 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.78700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.28700256 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.6289978 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.22599792 27.3220005 Tm [(en)-1(comp)1(ass)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.60099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.10101318 27.3220005 Tm [(so)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.53999996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.75099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.25099945 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.0929985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.5929985 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.54699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04699707 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.99699402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.49699402 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.65499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.15499878 42.92200089 Tm [(repression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.6499939 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.45700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.95700073 42.92200089 Tm [(maj)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(orit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.67000008 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.17000008 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.01200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.51200104 58.52199936 Tm [(zinc-finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.64600372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.14600372 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.6190033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.1190033 58.52199936 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.16799927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.66799927 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.64300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.14300537 58.52199936 Tm [(Kr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.29200745 58.52199936 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.83799744 58.52199936 Tm [(pp)1(e)-1(l-)1(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.69999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.19999695 58.52199936 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.70500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.20498657 58.52199936 Tm [(bi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5 74.12200165 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.32699966 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.82700348 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.10399628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.60399628 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.57900238 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.07900238 74.12200165 Tm [(KRA)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.64700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.14700317 74.12200165 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.14100647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.64100647 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.23800659 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.79899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.29899597 74.12200165 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.11199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.61199951 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.68699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.18701172 74.12200165 Tm [(int)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(eract)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.38400078 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.88400078 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.27999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.77999878 89.72200012 Tm [(KA)1(P1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.77600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.27600098 89.72200012 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.83200073 89.72200012 Tm [(rec)-1(ruit)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.31599426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.81599426 89.72200012 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.64599609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.14599609 89.72200012 Tm [(mod)1(i)-1(f)1(yi)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.53399658 89.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.87800026 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37800026 105.3219986 Tm [(ZSCAN21)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.54499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04499817 105.3219986 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.30200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.80200195 105.3219986 Tm [(calle)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.94300079 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.44300079 105.3219986 Tm [(ZNF3)-1(8,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84399414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.34399414 105.3219986 Tm [(Zipro)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.5039978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.0039978 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.16200256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.66200256 105.3219986 Tm [(NY-)1(REN-)1(2)-1(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.05999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.55999756 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.1210022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.6210022 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 120.92199707 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18899918 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.68899918 120.92199707 Tm [(ho)1(molog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.98100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.48100281 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.32299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.82299805 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.8239975 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.3239975 120.92199707 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.29699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.79699707 120.92199707 Tm [(Zscan2)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.13299561 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.63299561 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.94000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.44000244 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.71699524 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.21699524 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.77801514 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.27801514 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.25299072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.26399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.76399994 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.60599899 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.10599899 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.10700226 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.60700226 136.52200317 Tm [(Kr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.7559967 136.52200317 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30200195 136.52200317 Tm [(pp)1(e)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.30000305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.80000305 136.52200317 Tm [(C2H)-1(2-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.20199585 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.70199585 136.52200317 Tm [(zinc-finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.83599854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.33599854 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.41799927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.91799927 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.75999451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.26000977 136.52200317 Tm [(tr)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nsc)-1(r)1(i)-1(p)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.18999863 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.68999863 152.12199402 Tm [(regulat)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.74900055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.24900055 152.12199402 Tm [(Found)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.60099792 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.10099792 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.04200745 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.54200745 152.12199402 Tm [(pro)1(life)-1(r)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.92700195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.42700195 152.12199402 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.16900635 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.66900635 152.12199402 Tm [(ZSCAN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.3390007 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.8390007 167.72200012 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.65200043 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.15200043 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22699738 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.72699738 167.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.58100128 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.08100128 167.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.20799255 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.70799255 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.10400391 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.60400391 167.72200012 Tm [(ga)1(me)-1(t)1(ogene)-1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.19200134 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.69200134 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.63299561 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.13299561 167.72200012 Tm [(femal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 183.32200623 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.04899979 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.54899979 183.32200623 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.94499969 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.44499969 183.32200623 Tm [(mei)-1(o)1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.82800293 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.32800293 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26899719 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76899719 183.32200623 Tm [(males.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.01100159 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.51100159 183.32200623 Tm [(ZSCAN21)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.51199341 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.01199341 183.32200623 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.69400024 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.19400024 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.16900635 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.66900635 183.32200623 Tm [(SCAN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.53300476 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03300476 183.32200623 Tm [(do)1(mai)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 198.92199707 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.87400055 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.875 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.375 198.92199707 Tm [(N-t)1(e)-1(r)1(mi)-1(nus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.56700134 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.06700134 198.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.34400177 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84400177 198.92199707 Tm [(exhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.11099243 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.61099243 198.92199707 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.56500244 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.06500244 198.92199707 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.53700256 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.03700256 198.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.54901123 198.92199707 Tm [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>