%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 140 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 44 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 115.76399994 23.67700005 Tm 0 Tr [(ZSCAN1)1(8)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 203.94700623 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 314.38699341 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.38699341 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(ZS)-1(CAN)1(18)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 136.14700317 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.64700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.89700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ZSC)-1(A)1(N18)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.94400024 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.08999634 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.41099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.78500366 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.58099365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZNF447)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.48400116 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZS)-1(CAN)1(18)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.83699799 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 146.17500305 203.55000305 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.03499985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.53499985 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.89599991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.39599991 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.8690033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.3690033 11.72200012 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.41799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.91799927 11.72200012 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.46000671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.96000671 11.72200012 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.95300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.45300293 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.72999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.22999573 11.72200012 Tm [(ha)1(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.58100033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.08099937 27.3220005 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.44499969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.94499969 27.3220005 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.19799805 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.04000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.54000092 27.3220005 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.61300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.11300659 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.78700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.28700256 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.6289978 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.22599792 27.3220005 Tm [(en)-1(comp)1(ass)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.60099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.10101318 27.3220005 Tm [(so)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.53999996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.75099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.25099945 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.0929985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.5929985 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.54699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04699707 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.99699402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.49699402 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.65499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.15499878 42.92200089 Tm [(repression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.6499939 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.45700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.95700073 42.92200089 Tm [(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(jorit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0739994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.5739994 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.41600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.91600037 58.52199936 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 58.52199936 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.65599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.15599823 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6289978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.1289978 58.52199936 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.17799377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.67799377 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.65299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.15299988 58.52199936 Tm [(Kr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.30200195 58.52199936 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.8480072 58.52199936 Tm [(pp)1(e)-1(l-)1(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.71000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.21000671 58.52199936 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.71499634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.21499634 58.52199936 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(inding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.39599991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 74.12200165 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22299957 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.5 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.97499847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47499847 74.12200165 Tm [(KRA)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54299927 74.12200165 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.53700256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.03700256 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.13400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.63400269 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.19500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.69500732 74.12200165 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.50799561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.00799561 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.08300781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.58300781 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(teract)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.73699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.23699951 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.63299942 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.13299942 89.72200012 Tm [(KA)1(P1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.1289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.6289978 89.72200012 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.68499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.18499756 89.72200012 Tm [(rec)-1(ruit)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.66900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.16900635 89.72200012 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.99899292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.49899292 89.72200012 Tm [(mod)1(i)-1(f)1(yi)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.38699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.88699341 89.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ein)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.37999916 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.87999916 105.3219986 Tm [(ZSCAN18)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.8809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.3809967 105.3219986 Tm [(\(Zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.42199707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.92199707 105.3219986 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.28299713 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.78299713 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.05999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.55999756 105.3219986 Tm [(SCAN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.42399597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.92399597 105.3219986 Tm [(do)1(main-c)-1(o)1(ntaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.39199829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.89199829 105.3219986 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(rot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.55900002 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.05900002 120.92199707 Tm [(18)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.78699875 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.28699875 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.54399872 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.04399872 120.92199707 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.86299896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.36299896 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.5039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.0039978 120.92199707 Tm [(ZNF4)-1(47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.51699829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.01699829 120.92199707 Tm [(\(Zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.55799866 120.92199707 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.91900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.41900635 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.72599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.22599792 120.92199707 Tm [(44)-1(7\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.23199463 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.0359993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.5359993 136.52200317 Tm [(51)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.36899948 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.86899948 136.52200317 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.93900299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.43900299 136.52200317 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.07900238 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.57900238 136.52200317 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.84300232 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.34300232 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.18499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.68499756 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.68600464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.18600464 136.52200317 Tm [(Kr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.33500671 136.52200317 Tm [(?] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.8809967 136.52200317 Tm [(pp)1(e)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.8789978 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.3789978 136.52200317 Tm [(C2H)-1(2-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.78100586 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.28100586 136.52200317 Tm [(zin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.51300001 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.01299953 152.12199402 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.37400055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.87400055 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.18099976 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.68099976 152.12199402 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.26300049 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.54000092 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.04000092 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.60099792 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.10099792 152.12199402 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.91400146 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41400146 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.48899841 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.98899841 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.84300232 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.34300232 152.12199402 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.71200562 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.21200562 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.15299988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.65301514 152.12199402 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(anscript)1(i)-1(o)1(n)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.16500092 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.66500092 167.72200012 Tm [(regulat)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.06199646 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.56199646 167.72200012 Tm [(Localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.46899414 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.96899414 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.04400635 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.54400635 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54499817 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04499817 167.72200012 Tm [(nuc)-1(leu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.02999878 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.52999878 167.72200012 Tm [(ZSCAN18)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.53100586 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.21500015 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.71500015 183.32200623 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.0890007 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.5890007 183.32200623 Tm [(KRA)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.15699768 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.65699768 183.32200623 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.48400116 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.98400116 183.32200623 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.26100159 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.76100159 183.32200623 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.94200134 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.44200134 183.32200623 Tm [(C2H)-1(2-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.84399414 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.34399414 183.32200623 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2230072 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.7230072 183.32200623 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 198.92199707 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.56299973 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.06299973 198.92199707 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.16000366 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.66000366 198.92199707 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.40799713 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.90799713 198.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.07900238 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.57900238 198.92199707 Tm [(conve)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95399475 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.45399475 198.92199707 Tm [(DNA)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.125 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.625 198.92199707 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.1499939 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.6499939 198.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.92700195 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.42700195 198.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.73399353 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.23399353 198.92199707 Tm [(bin)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>