%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.5019989 23.67700005 Tm 0 g [(DC)-1(AF1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.09399414 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.79800415 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(DCAF)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.27999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.52999878 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.52999878 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DCAF)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.27999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.65399933 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.85600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.22999573 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.21000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.58399963 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.05799866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DDB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.95300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.32700348 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.38999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.76399994 12.82499981 Tm [(CUL4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.83599854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.21000671 12.82499981 Tm [(asso)-1(c)1(i)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.1269989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.50100708 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.88999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.26400757 12.82499981 Tm [(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.07400513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.44799805 12.82499981 Tm [(RIP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.02900696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.40299988 12.82499981 Tm [(VPRBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.62200928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1308)1(-1507)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.10299683 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13800049 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.1789856 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.21398926 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.64498901 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.67999268 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.17300415 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.20800781 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.89401245 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.9289856 12.04500008 Tm [(DCAF)-1(1)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 349.16900635 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 302.57299805 m 416.75 302.57299805 l 416.75 333.77301025 l -1.45000005 333.77301025 l h f* Q q /GS2 gs 1 g -1.45000005 333.77301025 m 416.75 333.77301025 l 416.75 364.97302246 l -1.45000005 364.97302246 l h f* Q q 1 0 0 1 0 302.57299805 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 364.97299194 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 392.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DD)1(B)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63599968 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13599968 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4129982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.9129982 11.72200012 Tm [(CUL4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.5490036 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.0490036 11.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1760025 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.6760025 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.79499817 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RIP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.69400024 11.72200012 Tm [(VPRBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.31600189 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y4B)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.24700165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(22)-1(79)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 120.27500153 16.35000038 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 119.52500153 0.75 l 119.52500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 120.52500153 -0.25 l 120.52500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 120.27500153 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 120.27500153 109.94999695 l h f* Q q 1 0 0 1 119.90000153 0 cm -0.625 -0.25 m 303.5249939 -0.25 l 303.5249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.36499977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.86499977 11.72200012 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.22900009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.72900009 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.86999893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.36999893 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.34500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.84500122 11.72200012 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.19499969 11.72200012 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.68600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.18600464 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.875 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.375 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.21699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.71699524 11.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.94299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.44299316 11.72200012 Tm [(ubiquitin-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 27.3220005 Tm [(ligas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.60100174 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.10099792 27.3220005 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.85199738 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.35199738 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.6289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.1289978 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.27000427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.77000427 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.29100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.79100037 27.3220005 Tm [(at)1(y)-1(p)1(ic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.90800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.40800476 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine-pr)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 42.92200089 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.15399933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.65399933 42.92200089 Tm [(playing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.23300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.73300171 42.92200089 Tm [(ke)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.50299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.00299835 42.92200089 Tm [(roles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.82899475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.32899475 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.27000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.77000427 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.73399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.23399353 42.92200089 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.36399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.86399841 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.6309967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.1309967 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.27200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.77200317 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.18200684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.68200684 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(yc)-1(le,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.94499969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.44499969 58.52199936 Tm [(telomerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.2440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.7440033 58.52199936 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.47499847 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.7519989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.2519989 58.52199936 Tm [(hist)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.08200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.58200073 58.52199936 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.07400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.57400513 58.52199936 Tm [(Pro)1(bab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.21099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.71099854 58.52199936 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ubst)1(rat)1(e)-1(-)1(spec)-1(ific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.53399658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.03399658 74.12200165 Tm [(ad)1(apt)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.38400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.88400269 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.72599792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.22599792 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.20100403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.70100403 74.12200165 Tm [(DCX)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.38200378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.88200378 74.12200165 Tm [(\(DD)1(B)-1(1-CU)1(L)-1(4-X-)1(box\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.68299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.18299866 74.12200165 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.40899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.90899658 74.12200165 Tm [(ubiqui)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(tin-)1(prot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49399948 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.99399948 89.72200012 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.78800201 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.28800201 89.72200012 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.93399811 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.43399811 89.72200012 Tm [(named)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.25100708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.75100708 89.72200012 Tm [(CUL4A-)1(RB)-1(X1-D)1(DB)-1(1-D)1(CAF1)-1(/VP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(RBP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.02899933 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.52899933 105.3219986 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.17499924 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.67500305 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.77200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.27200317 105.3219986 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.56399536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06399536 105.3219986 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.73500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.23500061 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.51199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.01199341 105.3219986 Tm [(pro)1(teasome-d)1(e)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 0.75 m 119.90000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 17.10000038 m 119.90000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 33.45000076 m 119.90000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 49.80000305 m 119.90000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 66.15000153 m 119.90000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 82.5 m 119.90000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 98.84999847 m 119.90000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.90000153 115.19999695 m 119.90000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>