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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.50299835 23.67700005 Tm 0 g [(DAP)-1(K)1(1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.09300232 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.79699707 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(DAP)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.98699951 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.98699951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DAP)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.11100006 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.31300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68699646 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.66700745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.04100037 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.51499939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(death-as)-1(sociated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.93600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.30999756 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.69200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.06599426 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.12600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.5 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.6309967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.00500488 12.82499981 Tm [(DAP)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.41999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1157)1(-1430)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.10299683 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13800049 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.1789856 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.21398926 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.64498901 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.67999268 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.17300415 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.20800781 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.89401245 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.9289856 12.04500008 Tm [(DAP)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.55999756 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.5289917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(deat)1(h-a)1(ssoci)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.25299835 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.55999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.05999756 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.147995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.647995 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.92599487 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DA)1(PK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.40699959 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P53)-1(35)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(66)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 122.47499847 16.35000038 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 121.72499847 0.75 l 121.72499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 122.72499847 -0.25 l 122.72499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 122.47499847 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 122.47499847 94.34999847 l h f* Q q 1 0 0 1 122.09999847 0 cm -0.625 -0.25 m 305.07501221 -0.25 l 305.07501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Deat)1(h-a)1(ssoci)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.85199738 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.35199738 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15899658 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.74699402 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.0249939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.5249939 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.08599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.58599854 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.56100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.06100464 11.72200012 Tm [(po)1(sitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.66999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.16999817 11.72200012 Tm [(mediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.84698486 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.68899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.18899536 11.72200012 Tm [(ga)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ma-)1(in)-1(t)1(e)-1(r)1(fe)-1(r)1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.06900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.56900024 27.3220005 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.18900299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.68900299 27.3220005 Tm [(pro)1(gra)1(mme)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.49299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.99299622 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.40299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.90299988 27.3220005 Tm [(deat)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.80200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.30200195 27.3220005 Tm [(DA)1(PK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.48699951 27.3220005 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.4039917 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.9039917 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.8789978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(st)1(ruc)-1(tura)1(ll)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.87799835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.37799835 42.92200089 Tm [(uni)-1(q)1(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.27400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.77400208 42.92200089 Tm [(16)-1(0-kD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.7559967 42.92200089 Tm [(calmodulin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.43200684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.93200684 42.92200089 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.95799255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45799255 42.92200089 Tm [(serine)-1(-)1(threonin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.69400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.19400024 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.41600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.91600037 58.52199936 Tm [(carries)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.94400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.44400024 58.52199936 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.22200012 58.52199936 Tm [(anky)-1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.78399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.28399658 58.52199936 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.17500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.67500305 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95199585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.45199585 58.52199936 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.72999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.22999573 58.52199936 Tm [(put)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.42999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.92999268 58.52199936 Tm [(P-)1(l)-1(o)1(op)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.91598511 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.41598511 58.52199936 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nsen)-1(sus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.24200058 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.74200058 74.12200165 Tm [(sites.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.09500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.59500122 74.12200165 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.59400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.09400177 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.65499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.15499878 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.12999725 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.62999725 74.12200165 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.12000275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.62000275 74.12200165 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.86099243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.36099243 74.12200165 Tm [(candidat)1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.90400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.40400696 74.12200165 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.12701416 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.62701416 74.12200165 Tm [(spli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ci)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.21100044 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.71100044 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.88000107 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.38000107 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.32099915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.82099915 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.19300079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.69300079 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.61500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.11500549 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.85099792 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 0.75 m 122.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 17.10000038 m 122.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 33.45000076 m 122.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 49.80000305 m 122.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 66.15000153 m 122.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 82.5 m 122.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 98.84999847 m 122.09999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 122.09999847 115.19999695 m 122.09999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92501831 209.17498779 l S Q Q q 1 0 0 1 0 605.01800537 cm Q Q 1 0 0 -1 0 841.90002441 cm
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