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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.66400146 23.67700005 Tm 0 g [(CTSA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.93099976 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 147.93099976 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 324.63500977 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CT)-1(SA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.61499786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 89.86499786 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.86500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CT)-1(SA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.61499786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.98899841 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.19100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56500244 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54499817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.91900635 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.39300537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cathepsi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.65100098 12.82499981 Tm [(A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.53600311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91000366 12.82499981 Tm [(GSL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.58200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.95599365 12.82499981 Tm [(GLB2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.83700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.21099854 12.82499981 Tm [(NG)1(BE)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.26100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.63499451 12.82499981 Tm [(PP)1(CA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.96699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.34100342 12.82499981 Tm [(PP)1(GB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.5249939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.30999756 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34500122 12.04500008 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.33500671 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.36999512 12.04500008 Tm [(154)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.05499268 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.08999634 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.1309967 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16600037 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.59700012 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.63200378 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.125 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.16000366 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.84599304 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88101196 12.04500008 Tm [(CT)-1(SA)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 276.4079895 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cath)1(e)-1(ps)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.34400177 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.84400177 11.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.17699814 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GSL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.67200089 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.17200089 11.72200012 Tm [(GLB2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.57500076 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.07500076 11.72200012 Tm [(NGBE;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.34600067 11.72200012 Tm [(PPCA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.87799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.37799835 11.72200012 Tm [(PPG)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.73100281 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P10)-1(61)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(59)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 169.0249939 31.95000076 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(PA)1(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47999954 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 169.0249939 16.35000038 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 168.2749939 0.75 l 168.2749939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 169.2749939 -0.25 l 169.2749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 169.0249939 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 169.0249939 94.34999847 l h f* Q q 1 0 0 1 168.6499939 0 cm -0.625 -0.25 m 258.5249939 -0.25 l 258.5249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.1269989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6269989 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.72399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.22399902 11.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.76100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.26100159 11.72200012 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 27.3220005 Tm [(lysosoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.77899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.27899933 27.3220005 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8259964 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.3259964 27.3220005 Tm [(beta)1(-ga)1(lac)-1(t)1(osida)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.65600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.15600586 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.43299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.93299866 27.3220005 Tm [(ne)-1(ura)1(min)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(da)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.00399971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.50399971 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.57899857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.07899857 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.79000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.29000092 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.26499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.76499939 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.2440033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.7440033 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.08599854 42.92200089 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.32099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.82099915 42.92200089 Tm [(molec)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.34199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.84199524 42.92200089 Tm [(weigh)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.10099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.60099792 42.92200089 Tm [(mul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(timers.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.55699921 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.36399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.86399841 58.52199936 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56600189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.06600189 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.90799713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.40799713 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.36399841 58.52199936 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.84300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.34300232 58.52199936 Tm [(pro)1(vides)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.397995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.897995 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.8730011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.3730011 58.52199936 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ctive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.09199905 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.59199905 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.2519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.7519989 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.02999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.52999878 74.12200165 Tm [(st)1(ability)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.07299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.57299805 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.84999847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.34999847 74.12200165 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.98800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.48800659 74.12200165 Tm [(Deficie)-1(nc)-1(ies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.70599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.20599365 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.14700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.64700317 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.10299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.5340004 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.0340004 89.72200012 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.13300323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63300323 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.70800018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.20800018 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.08000183 89.72200012 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.95700073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.45700073 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.29899597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.79899597 89.72200012 Tm [(ga)1(lac)-1(t)1(osialido)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.18600464 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 0.75 m 168.6499939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 17.10000038 m 168.6499939 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 33.45000076 m 168.6499939 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 49.80000305 m 168.6499939 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 66.15000153 m 168.6499939 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 98.1000061 m 168.6499939 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 114.45000458 m 168.6499939 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.6499939 130.80000305 m 168.6499939 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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