%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 119 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(ZMAT4)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 142.38299561 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 252.82299805 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ZMAT4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 130.15800476 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.65800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.90800476 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ZMA)1(T)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.14099884 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.51499939 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66099548 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.98199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.35600281 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.1519928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(zi)-1(nc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88800049 12.82499981 Tm [(fi)-1(nge)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.84600067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.22000122 12.82499981 Tm [(matr)1(i)-1(n-type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.96699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.34100342 12.82499981 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.66299438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZMAT4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.40799713 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 140.92500305 187.94999695 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Zinc)-1(-f)1(in)-1(g)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.29000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.79000092 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.26300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76300049 11.72200012 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.81199646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.31199646 11.72200012 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.85400391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.35400391 11.72200012 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.84700012 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.12399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.62399292 11.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.9710083 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 27.3220005 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.8390007 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.3390007 27.3220005 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.09199905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.59200287 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.43399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.93399811 27.3220005 Tm [(func)-1(t)1(ions,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.00700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.50700378 27.3220005 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.18099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.68099976 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.522995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.022995 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.11999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.61999512 27.3220005 Tm [(en)-1(comp)1(ass)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.99499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.49499512 27.3220005 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.92199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.71100044 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.21100044 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0530014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5530014 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.50700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.00700378 42.92200089 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.95700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.45700073 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.61500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.11500549 42.92200089 Tm [(repression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.11000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.61000061 42.92200089 Tm [(Zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.64500427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.14500427 42.92200089 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.50601196 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mat)1(rin-type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.00299835 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.50299835 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.80999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.30999756 58.52199936 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.58799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.08799744 58.52199936 Tm [(\(ZMAT4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.2440033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.7440033 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.30499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80499268 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.77999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.27999878 58.52199936 Tm [(22)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.11300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.61300659 58.52199936 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.68299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.18299866 58.52199936 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.82299805 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.32299805 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.63000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 74.12200165 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.93700027 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.43700027 74.12200165 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26100159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76100159 74.12200165 Tm [(mat)1(rin-type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.76400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.26400757 74.12200165 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.14300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.64300537 74.12200165 Tm [(fingers.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.33599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.83599854 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.64300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.14300537 74.12200165 Tm [(mat)1(rin-type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.14599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.87899971 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.37899971 89.72200012 Tm [(finger,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.90599823 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.40599823 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.50299835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.00299835 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.56400299 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.06400299 89.72200012 Tm [(very)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.09500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.59500122 89.72200012 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.78999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.28999329 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.23100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.73100281 89.72200012 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.18800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.68800354 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.76300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.26300049 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.26400757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.76400757 89.72200012 Tm [(cl)-1(a)1(ssic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.25698853 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.54199982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.04199982 105.3219986 Tm [(C2H)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.57900238 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.07900238 105.3219986 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.95800018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.45800018 105.3219986 Tm [(finger,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.98500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.48500061 105.3219986 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.73199463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.23199463 105.3219986 Tm [(first)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.70300293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.20300293 105.3219986 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.13400269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.63400269 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.57499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.07499695 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.07598877 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.57598877 105.3219986 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 120.92199707 Tm [(mat)1(rin-3)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.09799957 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.59799957 120.92199707 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.59700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.09700012 120.92199707 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.77899933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.27899933 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.53600311 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.03600311 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.54299927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.04299927 120.92199707 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.97399902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.47399902 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.41499329 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.91499329 120.92199707 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.82400513 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.32400513 120.92199707 Tm [(splice)-1(o)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.26099968 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.76099968 136.52200317 Tm [(RNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.32299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.82299805 136.52200317 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.46199799 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.96199799 136.52200317 Tm [(sugg)1(e)-1(st)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.51100159 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.01100159 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.98599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.48599243 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.14599609 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.64599609 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.58700562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.08700562 136.52200317 Tm [(pre-mR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.23001099 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(binding.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.31000137 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.81000137 152.12199402 Tm [(ZMAT4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.95400238 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.45400238 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.01499939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.51499939 152.12199402 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19799805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.69799805 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.772995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.272995 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.27400208 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.77400208 152.12199402 Tm [(nuc)-1(leu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.75900269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.25900269 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.53599548 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.03599548 152.12199402 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.21699524 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.71699524 152.12199402 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.4640007 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.9640007 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.27100372 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.77100372 167.72200012 Tm [(exist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.35299683 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.85299683 167.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.9940033 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.4940033 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.46900177 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.96900177 167.72200012 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.97200012 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.47200012 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.31399536 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.81399536 167.72200012 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.17900085 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.67900085 167.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.59399414 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.09399414 167.72200012 Tm [(eve)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ts)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.68599987 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 0.75 m 140.55000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 188.69999695 m 140.55000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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