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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.95200348 23.67700005 Tm 0 g [(CO)-1(G4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.64300537 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 150.64300537 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 327.34698486 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(COG4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.49700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 92.74700165 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.74699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COG4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.49700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8710022 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.07299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.4469986 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.42700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.80099487 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.2749939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(compo)-1(nent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.19300079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.56700134 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.30799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.68199921 12.82499981 Tm [(ol)-1(igomer)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.63999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.01400757 12.82499981 Tm [(gol)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.6289978 12.82499981 Tm [(compl)-1(e)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.69200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.06599426 12.82499981 Tm [(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19700623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.57099915 12.82499981 Tm [(COD)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.7130127 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.08700562 12.82499981 Tm [(CDG2J)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.43899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(586-7)1(85)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(COG4)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 336.80300903 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.68899918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.18899918 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.03099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.53099823 11.72200012 Tm [(oligo)1(me)-1(ric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.90599823 11.72200012 Tm [(go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.93099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.43099976 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91000366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.41000366 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.68800354 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(COD1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.65500069 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.15499878 11.72200012 Tm [(CDG)1(2)-1(J)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.56600189 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(9E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(13)-1(34)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 132.125 16.35000038 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 131.375 0.75 l 131.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 132.375 -0.25 l 132.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 132.125 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 132.125 94.34999847 l h f* Q q 1 0 0 1 131.75 0 cm -0.625 -0.25 m 295.42498779 -0.25 l 295.42498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.33000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.83000183 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.67199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.17199707 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.69299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.19299316 11.72200012 Tm [(oligo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(meric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.88400078 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.38400078 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.69100189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.19100189 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.66999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.16999817 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.53900146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.03900146 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.97999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.47999573 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.48100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.98100281 27.3220005 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.43800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.93800354 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.21499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.71499634 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.45599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.95599365 27.3220005 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.62100029 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.12100029 42.92200089 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.58200073 42.92200089 Tm [(ap)1(para)1(tus.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.66999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.16999817 42.92200089 Tm [(Defec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.39100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.89100647 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.33200073 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.78799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.28799438 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.80400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.30400085 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4750061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.9750061 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.82899475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.32899475 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.30400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.80400085 42.92200089 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.10998535 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.60998535 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.45199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.30799866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.80799866 58.52199936 Tm [(diso)1(rder)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.58399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.08399963 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.9260025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.4260025 58.52199936 Tm [(glyc)-1(o)1(syl)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.89100647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.39100647 58.52199936 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.36199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.86199951 58.52199936 Tm [(IIj.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.7230072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.2230072 58.52199936 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.21000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.71000671 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.63198853 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.13198853 58.52199936 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ants)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54000092 74.12200165 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.88199997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.38200378 74.12200165 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.3219986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.8219986 74.12200165 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.98199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.48199463 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.82899475 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.32899475 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.83599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.33599854 74.12200165 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.02600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.52600098 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.80400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.30400085 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.76000977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.26000977 74.12200165 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.27299976 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 0.75 m 131.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 17.10000038 m 131.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 33.45000076 m 131.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 49.80000305 m 131.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 66.15000153 m 131.75 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 82.5 m 131.75 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 98.84999847 m 131.75 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.75 115.19999695 m 131.75 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm
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