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cm /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(ZF)-1(A)1(ND5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.68600464 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.18600464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 189.43600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 13 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <</MCID 14 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ZFAN)1(D)-1(5)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 118.11000061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 120.48400116 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 149.2559967 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 151.63000488 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 201.95100403 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 204.32499695 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 242.1210022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZA20D2;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 99.22699738 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 101.60099792 12.82499981 Tm [(ZF)-1(A)1(ND5A;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 144.86199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 147.23599243 12.82499981 Tm [(ZNF216)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 179.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0019>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZF)-1(A)1(ND5)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 97.37599945 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 90 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 143.92500305 172.3500061 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Involved)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 36.61999893 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 41.11999893 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 49.06100082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 53.56100082 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 84.86799622 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 89.36799622 11.72200012 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 142.14599609 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 146.64599609 11.72200012 Tm [(via)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 158.74000549 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 163.24000549 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 177.24099731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 181.74099731 11.72200012 Tm [(ubiquitin-)1(prot)1(e)-1(a)1(som)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(system.)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 41.76100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 46.26100159 27.3220005 Tm [(May)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 64.79299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 69.29299927 27.3220005 Tm [(act)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 82.13400269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 86.63400269 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 97.14600372 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 101.64600372 27.3220005 Tm [(anchoring)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 145.07699585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 149.57699585 27.3220005 Tm [(ubiquitinat)1(e)-1(d)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 207.44900513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 211.94900513 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 247.42199707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 251.92199707 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 260.99700928 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 265.49700928 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(he)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 10.64799976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 15.14799976 42.92200089 Tm [(pro)1(teasome.)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 69.08200073 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 73.58200073 42.92200089 Tm [(Plays)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 95.38800049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 99.88800049 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 104.86299896 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 109.36299896 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 126.02300262 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 130.522995 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 138.46400452 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 142.96400452 42.92200089 Tm [(ubiquitin-)1(me)-1(dia)1(ted)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 226.42100525 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 230.92100525 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 262.22799683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 52.77799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 57.27799988 58.52199936 Tm [(during)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 85.71499634 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 90.21499634 58.52199936 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 120.375 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 124.875 58.52199936 Tm [(at)1(roph)1(y)-1(.)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 160.58099365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 165.08099365 58.52199936 Tm [(Plays)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 186.88699341 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 191.38699341 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 196.36199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 200.86199951 58.52199936 Tm [(role)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 217.52200317 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 222.02200317 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 229.96299744 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 234.46299744 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 248.46400452 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 252.96400452 58.52199936 Tm [(reg)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ulatio)1(n)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 29.93099976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 34.43099976 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 43.27299881 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 47.77299881 74.12200165 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 99.65000153 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 104.15000153 74.12200165 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 146.1000061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 150.6000061 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 166.8769989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 171.3769989 74.12200165 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 215.53799438 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 220.03799438 74.12200165 Tm [(Inhibit)1(s)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 251.82800293 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 256.32800293 74.12200165 Tm [(NF)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(-kap)1(pa-)1(B)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 39.77899933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 44.27899933 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 86.22899628 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 90.72899628 89.72200012 Tm [(tr)1(i)-1(g)1(gered)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 130.83299255 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 135.33299255 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 145.84500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 150.34500122 89.72200012 Tm [(overexpression)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 215.28700256 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 219.78700256 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 228.6289978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 233.1289978 89.72200012 Tm [(RIPK)1(1)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 258.14700317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 262.64700317 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nd)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 11.30300045 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [(TRAF6)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 43.22900009 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 47.72900009 105.3219986 Tm [(but)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 62.37599945 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 66.87599945 105.3219986 Tm [(not)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 81.49700165 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 85.99700165 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 94.83899689 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 99.33899689 105.3219986 Tm [(RELA)1(.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 123.27999878 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 127.77999878 105.3219986 Tm [(Inhibit)1(s)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 159.57000732 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 164.07000732 105.3219986 Tm [(also)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 181.32699585 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 185.82699585 105.3219986 Tm [(tumor)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 212.31700134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 216.81700134 105.3219986 Tm [(ne)-1(crosis)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 251.86799622 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 256.36801147 105.3219986 Tm [(fa)1(c)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(to)1(r)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 12.51099968 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 17.01099968 120.92199707 Tm [(\(TNF\),)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 42.4469986 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 46.9469986 120.92199707 Tm [(IL-1)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 63.38299942 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 67.88300323 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 84.16000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 88.66000366 120.92199707 Tm [(TLR4)-1(-)1(in)-1(d)1(uc)-1(ed)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 148.10499573 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 152.60499573 120.92199707 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 204.48199463 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 208.98199463 120.92199707 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 250.93200684 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 255.43200684 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 263.37298584 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 4.9749999 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 9.47500038 136.52200317 Tm [(do)1(se)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 81.14499664 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 85.64499664 136.52200317 Tm [(manne)-1(r)1(.)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 120.85399628 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 125.35399628 136.52200317 Tm [(Overexpression)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 191.90899658 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 196.40899658 136.52200317 Tm [(sensitizes)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 237.23399353 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 241.73399353 136.52200317 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 260.30999756 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 264.80999756 136.52200317 Tm [(t)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(o)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 5.72200012 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 10.22200012 152.12199402 Tm [(TNF-induc)-1(ed)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 65.99299622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 70.49299622 152.12199402 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 114.65399933 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 119.15399933 152.12199402 Tm [(Is)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 125.96600342 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 130.46600342 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 135.44099426 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 139.94099426 152.12199402 Tm [(po)1(ten)-1(t)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 168.76899719 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 173.26899719 152.12199402 Tm [(inhibito)1(ry)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 214.56399536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 219.06399536 152.12199402 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 244.18299866 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 248.68299866 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 260.96099854 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 265.46099854 152.12199402 Tm [(o)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(st)1(e)-1(oclast)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 37.74900055 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 42.24900055 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 105.74099731 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 265 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 266 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 267 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 188.69999695 cm q 1 g 0.375 0.75 m 143.17500305 0.75 l 143.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 144.17500305 -0.25 l 144.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 269 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 274 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.92500305 16.35000038 l h f* Q q 1 0 0 1 143.55000305 0 cm -0.625 -0.25 m 279.875 -0.25 l 279.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 275 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ZFAND5)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 36.14500046 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 0.75 m 143.55000305 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 173.1000061 m 143.55000305 188.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.55000305 189.45001221 m 143.55000305 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.07501221 m 422.42498779 189.07501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 205.42501831 m 423.17498779 205.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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