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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.8690033 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 156.63299561 23.67700005 Tm 0 Tr [(ZAP70)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 219.99000549 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 330.42999268 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ZAP)1(70)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.80999756 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.30999756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.05999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(ZA)1(P70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.79299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.16699982 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.93899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.31300354 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.63400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.00799561 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.80400085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(zeta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.91899872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.68599701 12.82499981 Tm [(chai)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.59799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.36499786 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.10600281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8730011 12.82499981 Tm [(T-cell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.68800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.45500183 12.82499981 Tm [(re)1(ceptor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.23599243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.00300598 12.82499981 Tm [(asso)-1(c)1(i)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.68699646 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.06900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.83599854 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.89599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.66299438 12.82499981 Tm [(70;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.88299561 12.82499981 Tm [(SRK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.67300415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 345.44000244 12.82499981 Tm [(ST)-1(D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.65100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.41799927 12.82499981 Tm [(TZ)-1(K)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 386.71600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 390.48300171 12.82499981 Tm [(ST)-1(CD;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29199219 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(IMD48;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.5359993 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.90999985 30.49699783 Tm [(ADMIO2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.15200043 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.52600098 30.49699783 Tm [(ZAP)1(-)-1(7)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.8010025 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ZAP)1(70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.05999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 141.67500305 187.94999695 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21600342 11.72200012 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.09700012 11.72200012 Tm [(belonging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.06900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.56900024 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.64399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.14399719 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.14500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.64500427 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.95199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.45199585 11.72200012 Tm [(tyr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(osine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.93499947 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.43499947 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52299881 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.02299881 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.27100372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77100372 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.04799652 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.54799652 27.3220005 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.29599762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.79599762 27.3220005 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.84300232 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.34300232 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.31799316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.81799316 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.97799683 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.91900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.41900635 27.3220005 Tm [(T-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.8809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.3809967 27.3220005 Tm [(developme)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6760006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.17599869 42.92200089 Tm [(lymphocyte)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.51499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.01499939 42.92200089 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.13200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.63200378 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.89399719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.39399719 42.92200089 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.94099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.44099426 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.03799438 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.59899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.09899902 42.92200089 Tm [(ph)1(osph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(orylat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.50799942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.00799942 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.27600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.77600098 58.52199936 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.26399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.76399994 58.52199936 Tm [(residues)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.44299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.94299316 58.52199936 Tm [(upon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.00500488 58.52199936 Tm [(T-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.96699524 58.52199936 Tm [(antig)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.64500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.14500427 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.56698608 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.06698608 58.52199936 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(TCR\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.06100082 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.56100082 74.12200165 Tm [(st)1(i)-1(mulat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.0059967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.5059967 74.12200165 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.41300201 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.91300201 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.85400391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.35400391 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.35499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.85499573 74.12200165 Tm [(initial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.30900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.80900574 74.12200165 Tm [(st)1(e)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.18299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.68299866 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.5249939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.0249939 74.12200165 Tm [(TCR-mediat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.59600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.09600067 89.72200012 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.40399933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.90399933 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34500122 89.72200012 Tm [(combinatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.69200134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.19200134 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.58799744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.08799744 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.08900452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.58900452 89.72200012 Tm [(Src)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.73300171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.23300171 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.31500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.81500244 89.72200012 Tm [(ki)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.625 105.3219986 Tm [(Lc)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.6570015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.1570015 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43399811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93399811 105.3219986 Tm [(Fy)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.19100189 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.69100189 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.95300293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.45300293 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.33399963 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.89500427 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.39500427 105.3219986 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.6519928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1519928 105.3219986 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.36000061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.86000061 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.13800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.63800049 105.3219986 Tm [(th)1(y)-1(mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cy)-1(t)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.73600006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.23600006 120.92199707 Tm [(development.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.40000153 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.90000153 120.92199707 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.74899292 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.24899292 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.19000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.69000244 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.14599609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.64599609 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.16200256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.66200256 120.92199707 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.96800232 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.46800232 120.92199707 Tm [(sele)-1(ctive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.33401489 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.83401489 120.92199707 Tm [(T-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.40999985 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.90999985 136.52200317 Tm [(defec)-1(t)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.03300095 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.53300095 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.50799942 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.00799942 136.52200317 Tm [(seve)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.65399933 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.15399933 136.52200317 Tm [(combine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.37399292 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.87399292 136.52200317 Tm [(immun)-1(o)1(defic)-1(ienc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.16499329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.66499329 136.52200317 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.33599854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.83599854 136.52200317 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ara)1(c)-1(t)1(e)-1(riz)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.47900009 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.97900009 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.49100113 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.99099731 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.96600342 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.46600342 152.12199402 Tm [(sele)-1(ctive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33200073 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.83200073 152.12199402 Tm [(ab)1(se)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.99299622 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.49299622 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.33500671 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.83500671 152.12199402 Tm [(CD8-p)1(ositive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.49200439 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.99200439 152.12199402 Tm [(T-ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.7869873 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.2869873 152.12199402 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 167.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.25 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.75 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.31999969 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.81999969 167.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.04199982 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.54199982 167.72200012 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.29200745 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.79200745 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.73199463 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.23199463 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.39199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.89199829 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.23901367 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.73901367 167.72200012 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ee)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75899982 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25900078 183.32200623 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.94900131 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.44900131 183.32200623 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.72700119 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.22699738 183.32200623 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.68299866 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.18299866 183.32200623 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.86499786 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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