%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.72499847 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 160.48899841 23.67700005 Tm 0 Tr [(XRN)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.13400269 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.57400513 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(XRN2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 123.00099945 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.50100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.75100708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(XRN)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.98400116 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.35800171 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.13000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.5039978 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.82499695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.19900513 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.99499512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(5'-3')] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.49299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.86699677 12.82499981 Tm [(exorib)-1(onu)-1(clease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.76800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.14199829 12.82499981 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.46400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XRN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.25099945 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 146.17500305 63.15000153 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(5')-1(-)1(3)-1(')] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.73300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.23300171 11.72200012 Tm [(exonuc)-1(lease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.97599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.47599792 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.69799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.19799805 11.72200012 Tm [(pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.88499451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.38499451 11.72200012 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(cription)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.10800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.60800171 27.3220005 Tm [(terminat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.86799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36799622 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.69599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.19599915 27.3220005 Tm [(cotra)1(n)-1(s)1(c)-1(ript)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.38499451 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.88499451 27.3220005 Tm [(cl)-1(eava)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.43600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.93600464 27.3220005 Tm [(sites.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.28900146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.78900146 27.3220005 Tm [(Alt)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5359993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0359993 42.92200089 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9509964 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.4509964 42.92200089 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.62000275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.12000275 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.06099701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.56099701 42.92200089 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.93299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.43299866 42.92200089 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.35499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.85499573 42.92200089 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.42500305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.92500305 42.92200089 Tm [(en)-1(cod)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.74300003 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.24300003 58.52199936 Tm [(isof)1(orms.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.06999969 58.52199936 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.72099304 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.22099304 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.73300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.23300171 58.52199936 Tm [(RefSeq,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.55900574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.05900574 58.52199936 Tm [(Dec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.53399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.03399658 58.52199936 Tm [(20)-1(15)-1(])] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.15100098 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(XRN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.27499962 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(XRN2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.6210022 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(5')-1(-)1(3)-1(')] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.06299973 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.56299973 11.72200012 Tm [(exoribo)1(n)-1(ucle)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.60700226 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.10700226 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.38500214 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(0D6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.98400116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 19.52199936 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 19.52199936 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 146.17500305 31.95000076 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(colorec)-1(t)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.08999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.58999634 11.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.18000031 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.45700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.95700073 11.72200012 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.41700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.91700745 11.72200012 Tm [(lymph)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79800415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.29800415 11.72200012 Tm [(node)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.42900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.92900085 11.72200012 Tm [(tiss)1(u)-1(e;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.82800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.32800293 11.72200012 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(uman)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.5 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29 27.3220005 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4679985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.9679985 27.3220005 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.05799866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.55799866 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.83499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.33499908 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.29499817 27.3220005 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.26300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.76300049 27.3220005 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.85299683 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.8500061 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(Recommend)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.78299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.28299713 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 120.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(50)-1(0-20)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.83800125 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 193.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(10)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.83300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33300018 11.72200012 Tm [(KD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.90100098 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 63.90000153 m 145.80000305 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 80.25 m 145.80000305 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 96.59999847 m 145.80000305 112.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 112.94999695 m 145.80000305 128.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 129.30000305 m 145.80000305 144.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 145.65000916 m 145.80000305 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 177.6000061 m 145.80000305 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 193.95001221 m 145.80000305 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.2250061 m 422.42498779 177.2250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 193.57501221 m 422.42498779 193.57501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.92501831 m 423.17498779 209.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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