%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.05001831 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.32700348 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 156.09100342 23.67700005 Tm 0 Tr [(XRCC5)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 220.53300476 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 330.97299194 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(XRCC5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 127.41999817 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(XRCC5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.40399933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.77799988 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.55000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.92399597 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.24499512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.6190033 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.41499329 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(X-ray)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.10700226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.48100281 12.82499981 Tm [(re)1(p)-1(air)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98200226 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.35600281 12.82499981 Tm [(cr)1(o)-1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.58099365 12.82499981 Tm [(compl)-1(e)1(menti)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.61099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98500061 12.82499981 Tm [(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.49000549 12.82499981 Tm [(KU)1(80;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.13499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.50900269 12.82499981 Tm [(KU)1(B2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.54400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.91799927 12.82499981 Tm [(Ku86;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.34298706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.7170105 12.82499981 Tm [(NFIV;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.73199463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.10598755 12.82499981 Tm [(KA)1(RP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 358.89300537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 361.26699829 12.82499981 Tm [(KA)1(RP-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 392.45901489 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XRCC5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 140.17500305 187.94999695 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.16700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.66700745 11.72200012 Tm [(80)-1(-)1(k)-1(iloda)1(lton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.7749939 11.72200012 Tm [(subu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29399967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79399967 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63599968 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.13599968 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.13700104 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.63700104 27.3220005 Tm [(Ku)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.89599991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.39599991 27.3220005 Tm [(heterod)1(ime)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.79000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.29000092 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.59700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.09700012 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.19400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.69400024 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.25500488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.75500488 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.01199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.51199341 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.33099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.83099365 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.97198486 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.47198486 27.3220005 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(TP-d)1(e)-1(p)1(e)-1(nda)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.45299911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.95300293 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.45800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.95800018 42.92200089 Tm [(helic)-1(as)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.15599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.65600586 42.92200089 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.94700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.44700623 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.10499573 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.61000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.11000061 42.92200089 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.20700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.70700073 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.01400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.51400757 42.92200089 Tm [(XRCC5.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.67999268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(Ku)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.25899982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.75899982 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.31999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.81999969 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.82099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.32099915 58.52199936 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.86299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.36299896 58.52199936 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.05200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.55200195 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.39399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.89399719 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.89500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.39500427 58.52199936 Tm [(DNA)1(-dependent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.81900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.31900024 58.52199936 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.55900002 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.05900002 74.12200165 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.31299973 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81299973 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.08999634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.58999634 74.12200165 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.83799744 74.12200165 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.74499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.24499512 74.12200165 Tm [(to)1(gether)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11999512 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.51600647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.01600647 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.01699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.51699829 74.12200165 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.02200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.52200317 74.12200165 Tm [(ligase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.31600952 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(IV-XRCC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.625 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.125 89.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.60399628 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.10399628 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.04499817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.54499817 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.54599762 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.04599762 89.72200012 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.14300537 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.64300537 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.48500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.98500061 89.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.49000549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.99000549 89.72200012 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.38999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.88999939 89.72200012 Tm [(brea)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9000001 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.39999962 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.91200066 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.41200066 105.3219986 Tm [(non-ho)1(mologo)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.84400177 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.34400177 105.3219986 Tm [(en)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.75299835 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.25299835 105.3219986 Tm [(joining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.01699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.51699829 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.79400635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.29400635 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.29499817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79499817 105.3219986 Tm [(completion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.72799683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.22799683 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.07000732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.57000732 105.3219986 Tm [(V\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(D\)J)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.42500019 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.92499924 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.81500244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.31500244 120.92199707 Tm [(eve)-1(nt)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.48300171 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.98300171 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.24499512 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.74499512 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.26100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.76100159 120.92199707 Tm [(func)-1(t)1(ionally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.02999878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.52999878 120.92199707 Tm [(compleme)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.51900005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.01900005 136.52200317 Tm [(Chinese)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.90100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.40100098 136.52200317 Tm [(ha)1(mster)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.41200256 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.91200256 136.52200317 Tm [(xrs-)1(6)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.41400146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91400146 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.88899994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.38899994 136.52200317 Tm [(mutant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.59500122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.09500122 136.52200317 Tm [(defec)-1(t)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.2769928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.7769928 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.71800232 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.21800232 136.52200317 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.7230072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.2230072 136.52200317 Tm [(do)1(u)-1(b)1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(-st)1(rand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.12599945 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.62599945 152.12199402 Tm [(break)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.79199982 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.29199982 152.12199402 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.38899994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.88899994 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.16600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.66600037 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.60700226 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.10700226 152.12199402 Tm [(ab)1(i)-1(lit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.1309967 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.6309967 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70599365 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.20599365 152.12199402 Tm [(undergo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.07600403 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.57600403 152.12199402 Tm [(V\(D\)J)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.09399414 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.59399414 152.12199402 Tm [(rec)-1(o)1(mbi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(natio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.70299911 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.20299911 167.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.5359993 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.0359993 167.72200012 Tm [(rar)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.99000168 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.48999786 167.72200012 Tm [(mic)-1(r)1(osat)1(e)-1(llite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.23400116 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.73399353 167.72200012 Tm [(po)1(l)-1(ymor)1(phism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.23699951 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.73699951 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.67799377 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.17799377 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.63400269 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.13400269 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.6499939 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.1499939 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.71099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.21099854 167.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(sociated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.98699951 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.48699951 183.32200623 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.88299942 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.38299942 183.32200623 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.47299957 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.97299957 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.91400146 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.41400146 183.32200623 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.05599976 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55599976 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.397995 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.897995 183.32200623 Tm [(var)1(y)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.49499512 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.99499512 183.32200623 Tm [(rad)1(iosen)-1(s)1(i)-1(t)1(ivity.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.80899048 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.06500053 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56499863 11.72200012 Tm [(IP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71699905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 188.69999695 m 139.80000305 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>