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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.28700256 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 164.05099487 23.67700005 Tm 0 Tr [(XI)1(AP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 212.57299805 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 323.01300049 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(XIAP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 119.34500122 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.84500122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.34500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(XIA)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.70300293 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.4750061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.84899902 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.16999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.54400635 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.33999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(XIAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.59500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 379.85101318 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 219.1499939 l 0.375 219.1499939 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 220.1499939 l -0.625 220.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 113.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 113.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 219.1499939 l 146.17500305 219.1499939 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 220.1499939 l -0.625 220.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63900757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.13900757 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.21400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.71400452 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.68899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.18899536 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.27099609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.77099609 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.61300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.11300659 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(po)1(pto)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.55400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.05400085 27.3220005 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.29499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.79499817 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.43400574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.93400574 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.72399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.22399902 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.06599426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.56599426 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.02200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.52200317 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.60400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.10400391 27.3220005 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.32901001 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.55199814 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.05199814 42.92200089 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.07499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.57499695 42.92200089 Tm [(termed,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.93399811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.43399811 42.92200089 Tm [(ba)1(c)-1(ulovirus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.6000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.1000061 42.92200089 Tm [(IAP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.58399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.08399963 42.92200089 Tm [(repeat,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.97599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.47599792 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.57299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.07299805 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.63400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ne)-1(cessary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.77899933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.27899933 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.55699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.05699921 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.88999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.38999939 58.52199936 Tm [(anti-)1(apo)1(pto)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.08000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.58000183 58.52199936 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.48699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.98699951 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.24899292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.74899292 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.05599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.55599976 58.52199936 Tm [(fun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ctions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.69499969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.19499969 74.12200165 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.09200287 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.59200287 74.12200165 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.73600006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.23600006 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.31099701 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.81099701 74.12200165 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.30099487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.80099487 74.12200165 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.852005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.352005 74.12200165 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.47099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.97099304 74.12200165 Tm [(rec)-1(ept)1(or-)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ssociat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.15299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.65299988 89.72200012 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.93800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.43800354 89.72200012 Tm [(TRAF1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.86399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.36399841 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.64099884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.14100647 89.72200012 Tm [(TRAF2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.56700134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.06700134 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.34399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.84399414 89.72200012 Tm [(inhibits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.38400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.88400269 89.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.87799072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.37799072 89.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nduc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.22499847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.72499847 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.23699951 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.73699951 105.3219986 Tm [(men)-1(a)1(dione,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.48899841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.98899841 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.96399689 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.46399689 105.3219986 Tm [(po)1(ten)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.29200745 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.79200745 105.3219986 Tm [(induc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.09199524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.59199524 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.43400574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.93400574 105.3219986 Tm [(free)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.70399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.20399475 105.3219986 Tm [(rad)1(ic)-1(als,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.98199463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.48199463 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 120.92199707 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.52799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.02799988 120.92199707 Tm [(1-beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.38200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.88200378 120.92199707 Tm [(conve)-1(rt)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.98100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.48100281 120.92199707 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.02799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.52799988 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.78999329 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.28999329 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.59700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.09700012 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.35400391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(inhibits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.54000092 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.04000092 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.36800003 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.86800003 136.52200317 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.86299896 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.36299896 136.52200317 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.54399872 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.04399872 136.52200317 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.47399902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.97399902 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.81599426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.31599426 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.31700134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.81700134 136.52200317 Tm [(caspa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.46600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.96600342 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.04800415 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.54800415 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.38999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.88999939 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(-d)1(e)-1(a)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.62599945 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.12599945 152.12199402 Tm [(pro)1(teases,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.07099915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.57099915 152.12199402 Tm [(caspa)1(se)-1(-)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.39099884 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.89100647 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.16799927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.66799927 152.12199402 Tm [(caspa)1(se)-1(-)1(7)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.65499878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.15499878 152.12199402 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.0039978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.5039978 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.44500732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.94500732 152.12199402 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.57699966 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.07699966 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.59500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.09500122 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.09600067 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.59600067 167.72200012 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.90200043 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.40200043 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.2440033 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.7440033 167.72200012 Tm [(X-link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.54200745 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.04200745 167.72200012 Tm [(lymphop)1(roliferat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.55799866 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.05799866 167.72200012 Tm [(syndr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.4279995 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.9279995 183.32200623 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.53199768 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.03199768 183.32200623 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.9469986 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.4469986 183.32200623 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.61599731 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.11599731 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.05700684 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.55700684 183.32200623 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.92900085 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.42900085 183.32200623 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.35099792 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.85099792 183.32200623 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 198.92199707 Tm [(Pseudog)1(e)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31800079 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.81800079 198.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.66000366 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.16000366 198.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.61599731 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.11599731 198.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63200378 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.13200378 198.92199707 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.6499939 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.1499939 198.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.83999634 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.33999634 198.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.60800171 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.10800171 198.92199707 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.06900024 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.56900024 198.92199707 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.84698486 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 214.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 214.52200317 Tm [(11)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.49900055 214.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 219.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 235.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 219.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 219.8999939 m 145.80000305 235.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 235.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 219.5249939 m 422.42498779 219.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 235.875 m 423.17498779 235.875 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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