%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 114 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.9940033 23.67700005 Tm 0 g [(CLIC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.60099792 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.60099792 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 326.30499268 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CL)-1(IC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.57900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.82900238 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.82899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CL)-1(IC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.57900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.95300293 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.52899933 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.50900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.88299561 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.35699463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(chl)-1(orid)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.71499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.08899689 12.82499981 Tm [(in)-1(tr)1(acell)-1(ul)-1(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.32299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.69700623 12.82499981 Tm [(chan)-1(nel)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.3500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.72399902 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.85499573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.22900391 12.82499981 Tm [(G6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.98399353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.35800171 12.82499981 Tm [(NCC27)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.977005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(47-24)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(CL)-1(IC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.45401001 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 30.76399994 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 30.76399994 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 373.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chloride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.86600113 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.36600113 11.72200012 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.83300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.33300018 11.72200012 Tm [(channe)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.95600128 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.45599365 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.73399353 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(G6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.13700008 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.63699913 11.72200012 Tm [(NCC27)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.55099869 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O00)-1(29)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(64)-1(52)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 188.125 31.95000076 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(DS-)1(PAGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.42300034 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 188.125 16.35000038 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 187.375 0.75 l 187.375 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 188.375 -0.25 l 188.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 188.125 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 188.125 109.94999695 l h f* Q q 1 0 0 1 187.75 0 cm -0.625 -0.25 m 239.42500305 -0.25 l 239.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Chlor)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.37400055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.87400055 11.72200012 Tm [(channe)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.66300201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.16300201 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.18099976 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.15599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.65599823 11.72200012 Tm [(diverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.34700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.84700012 11.72200012 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55599976 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.397995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.897995 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.3710022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 27.3220005 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.39699936 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.89699936 27.3220005 Tm [(funda)1(me)-1(nta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.64800262 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.14800262 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.91000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.41000366 27.3220005 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.53999329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.03999329 27.3220005 Tm [(inc)-1(lud)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 42.92200089 Tm [(st)1(abilizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.54000092 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.88200378 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.29199982 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.79199982 42.92200089 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.57600403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.07600403 42.92200089 Tm [(po)1(ten)-1(t)1(ial,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.83500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.33500671 42.92200089 Tm [(tr)1(anse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pit)1(hel)-1(ia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.30400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.80400085 58.52199936 Tm [(tr)1(anspor)1(t,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.70600128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.20600128 58.52199936 Tm [(maintenanc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.69999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.19999695 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.04200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.54200745 58.52199936 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.00900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.50900269 58.52199936 Tm [(pH,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.38400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 74.12200165 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.00800323 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.50800323 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.34999847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.84999847 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.26000214 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.76000214 74.12200165 Tm [(volume.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.85299683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.35299683 74.12200165 Tm [(Chlor)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.727005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.227005 74.12200165 Tm [(intra)1(c)-1(ell)-1(ula)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 89.72200012 Tm [(channe)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.56000137 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.06000137 89.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.33800125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.83800125 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.39899826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.89900208 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.87400055 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.37400055 89.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.63800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.13800049 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.98000336 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.47999573 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.48100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.98100281 89.72200012 Tm [(p64)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.28500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.78500366 89.72200012 Tm [(fa)1(mi)-1(ly;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.03300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.53300476 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.53399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.03399658 89.72200012 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 105.3219986 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.7140007 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.21399689 105.3219986 Tm [(principally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.52400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.02400208 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.09899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.59899902 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.6000061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.1000061 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.50999451 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.00999451 105.3219986 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.82800293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.32800293 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.60499573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.10499573 105.3219986 Tm [(e)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 0.75 m 187.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 17.10000038 m 187.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 33.45000076 m 187.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 49.80000305 m 187.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 66.15000153 m 187.75 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 98.1000061 m 187.75 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 114.45000458 m 187.75 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 187.75 130.80000305 m 187.75 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 240 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 240.375 m 426.92498779 240.375 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>