%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 145 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.55200195 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 151.31599426 23.67700005 Tm 0 Tr [(WD)-1(R7)1(7)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 225.30799866 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 335.74798584 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(WDR77)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.89599609 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.39599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.14599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(W)1(DR77)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.8789978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.25299835 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.0249939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.39900208 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.72000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.09399414 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.88999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 12.82499981 Tm [(re)1(p)-1(e)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72200012 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1190033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.49299622 12.82499981 Tm [(77;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.94599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.32000732 12.82499981 Tm [(p44;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.28999329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.66400146 12.82499981 Tm [(MEP50;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.64599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.02000427 12.82499981 Tm [(MEP-50;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.21600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.58999634 12.82499981 Tm [(HKMT106)1(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.77801514 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.15200806 12.82499981 Tm [(Nbla10071;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 359.3039856 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 361.67800903 12.82499981 Tm [(p44/Mep50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 412.25500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR77)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 148.42500305 141.1499939 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.68699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.18699646 11.72200012 Tm [(andr)1(ogen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53199768 11.72200012 Tm [(rec)-1(ept)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(coactivat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.61800003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.11800003 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.33999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.83999634 27.3220005 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.71700287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.21700287 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.19200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.69200134 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.17100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.67100525 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.06700134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.56700134 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.87399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.37399292 27.3220005 Tm [(arg)1(in)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.52999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.97899628 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47899628 42.92200089 Tm [(5,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.92299652 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.42299652 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.51999664 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.01999664 42.92200089 Tm [(mod)1(i)-1(f)1(ie)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.11399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.61399841 42.92200089 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.57099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.07099915 42.92200089 Tm [(arg)1(in)-1(ines)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.39300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.89300537 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.96800232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.46798706 42.92200089 Tm [(di)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(methylarg)1(in)-1(ines)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.91500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.41500092 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.35600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.85600281 58.52199936 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.76499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.26499939 58.52199936 Tm [(splice)-1(o)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.00100708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.50100708 58.52199936 Tm [(Sm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.12800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.62800598 58.52199936 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.26699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.76699829 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.57400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.07400513 58.52199936 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nc)-1(o)1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.40100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.90100098 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.20800018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.70800018 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3789978 74.12200165 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.23300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.73300171 74.12200165 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.102005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.602005 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.54299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.04299927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.04400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 74.12200165 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.22000122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.72000122 74.12200165 Tm [(st)1(ages)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.24299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.74299622 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.58500671 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.08500671 74.12200165 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ost)1(at)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.67499924 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17499924 89.72200012 Tm [(canc)-1(er,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.43099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.93099976 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.32700348 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.82700348 89.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.50099945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.00099945 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.84300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.34300232 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.34399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.84399414 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.15100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.65100098 89.72200012 Tm [(being)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.20300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.70300293 89.72200012 Tm [(nuc)-1(lear-lo)1(c)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.68400002 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.18400002 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.625 105.3219986 Tm [(benign)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22299957 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.7990036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2990036 105.3219986 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.94599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.44599915 105.3219986 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.42300415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.92300415 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.86399841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.36399841 105.3219986 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.45399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.95399475 105.3219986 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.69599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.19599915 105.3219986 Tm [(Se)-1(v)1(e)-1(ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.39499998 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.89499998 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.81700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.31700134 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.88700104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.38700104 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.72900391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.22900391 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.16900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.66900635 120.92199707 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.82899475 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.32899475 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.67599487 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.17599487 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.68301392 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.69000053 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.19000053 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.4679985 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.9679985 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.42399979 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9240036 136.52200317 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.60600281 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.89900017 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)1(R7)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.44499969 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.8500061 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(WD)1(R7)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.79100037 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 147.67500305 0.75 l 147.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 148.67500305 -0.25 l 148.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 148.42500305 16.35000038 l h f* Q q 1 0 0 1 148.05000305 0 cm -0.625 -0.25 m 275.375 -0.25 l 275.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(77)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.62200165 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 0.75 m 148.05000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 141.8999939 m 148.05000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 158.25 m 148.05000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 174.6000061 m 148.05000305 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.05000305 190.95001221 m 148.05000305 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.2250061 m 422.42498779 174.2250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 190.57501221 m 422.42498779 190.57501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.92501831 m 423.17498779 206.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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