%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.8010025 23.67700005 Tm 0 g [(CILK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.79499817 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.79499817 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 326.49899292 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CIL)-1(K)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.68499756 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.68499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CIL)-1(K)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.80899811 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.38500214 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.73899841 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.21299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cil)-1(io)-1(g)1(enesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.73699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.11100006 12.82499981 Tm [(asso)-1(c)1(i)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.02799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.4019928 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.46200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.83599854 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.96699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.34100342 12.82499981 Tm [(ECO)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.82800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.20199585 12.82499981 Tm [(ICK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.71099854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.08500671 12.82499981 Tm [(MRK)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.02801514 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.40200806 12.82499981 Tm [(LC)-1(K)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.00100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.375 12.82499981 Tm [(EJM10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.4710083 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-292)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(CIL)-1(K)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 326.76901245 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ci)-1(liog)1(e)-1(nesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6629982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.1629982 11.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.29000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.79000092 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.87800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.37800598 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.65600586 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ECO;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.46999931 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.96999931 11.72200012 Tm [(ICK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.51499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.01499939 11.72200012 Tm [(MRK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.56300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.06300354 11.72200012 Tm [(LCK2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.85900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.35900116 11.72200012 Tm [(EJM10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.22000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UPZ9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.6969986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(35)-1(80)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 160.875 31.95000076 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 160.875 16.35000038 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 160.125 0.75 l 160.125 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 161.125 -0.25 l 161.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.875 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 160.875 94.34999847 l h f* Q q 1 0 0 1 160.5 0 cm -0.625 -0.25 m 266.67498779 -0.25 l 266.67498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Eukaryotic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.55199814 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.05199814 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.35900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.85900116 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.11299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.61299896 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.1309967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.6309967 11.72200012 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.17799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.67799377 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.8999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.3999939 11.72200012 Tm [(belong)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.67399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.17399597 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.24899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.74899292 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.72399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(very)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.03100014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.53100014 27.3220005 Tm [(extensive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.59600067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.09600067 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.1780014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6780014 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.51999664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.01999664 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.49299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.99299622 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.08999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.58999634 27.3220005 Tm [(sha)1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.81500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.31500244 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.28999329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.78999329 27.3220005 Tm [(conse)-1(rv)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.49200058 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.99200058 42.92200089 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.76999664 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.26999664 42.92200089 Tm [(common)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.63899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.13899994 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.53500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.03500366 42.92200089 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.39900208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.89900208 42.92200089 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.25300598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75300598 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.02999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.48799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.98799896 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.29499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.79499817 58.52199936 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.21499634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.71499634 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.977005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.477005 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.99299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.49299622 58.52199936 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.41000366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91000366 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.43099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.93099976 58.52199936 Tm [(intestinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.16099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.35399628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.85399628 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.94200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.44200134 74.12200165 Tm [(ha)1(rboring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.99899292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.49899292 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.47399902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.97399902 74.12200165 Tm [(dual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.64599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.14599609 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.92001343 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02099991 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52099991 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.71099854 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.65200043 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.15200043 89.72200012 Tm [(mito)1(gen)-1(-)1(activat)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.34300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.84300232 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.1499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.6499939 89.72200012 Tm [(\(MAP)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.29400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.79400635 89.72200012 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21400452 89.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 0.75 m 160.5 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 17.10000038 m 160.5 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 33.45000076 m 160.5 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 49.80000305 m 160.5 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 66.15000153 m 160.5 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 98.1000061 m 160.5 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 114.45000458 m 160.5 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.5 130.80000305 m 160.5 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>