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12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(WDR61)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.89599609 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.39599609 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 189.64599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(W)1(DR61)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 115.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 118.25299835 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 147.0249939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 149.39900208 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 199.72000122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 202.09399414 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 239.88999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(REC14;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 92.87999725 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 95.2539978 12.82499981 Tm [(SKI8)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 113.50099945 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(WDR61)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 95.14600372 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0021002200230024000E>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0025>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130028000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 76 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 79 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 143.17500305 78.75 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WD)1(R6)-1(1)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 32.44499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 36.94499969 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 43.50600052 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 48.00600052 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 52.98099899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 57.48099899 11.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 89.78099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 94.28099823 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 103.1230011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 107.6230011 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 121.62400055 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 126.12400055 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 156.16499329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 160.66499329 11.72200012 Tm [(PA)1(F)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 177.28500366 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 181.78500366 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 198.06199646 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 202.56199646 11.72200012 Tm [(SKI)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 216.11500549 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 220.61500549 11.72200012 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 268.5329895 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 25.09700012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 29.59700012 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 65.33799744 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 69.83799744 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 77.77899933 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 82.27899933 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 144.23300171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 148.73300171 27.3220005 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 192.96400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 197.46400452 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 213.74099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 218.24099731 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 231.75900269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 236.25900269 27.3220005 Tm [(involve)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 18.19799995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 22.69799995 42.92200089 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 50.70000076 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 55.20000076 42.92200089 Tm [(do)1(wnstr)1(e)-1(am)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 108.80000305 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 113.30000305 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 122.14199829 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 126.64199829 42.92200089 Tm [(RNA)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 146.16700745 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 150.66700745 42.92200089 Tm [(synthesis,)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 192.03700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 196.53700256 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 216.30400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.80400085 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 229.94500732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 234.44500732 42.92200089 Tm [(RNA)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 253.97000122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 258.47000122 42.92200089 Tm [(sur)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(veil)-1(la)1(n)-1(ce)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 37.15599823 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 41.65599823 58.52199936 Tm [(\(Zhu)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 61.33000183 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 65.83000183 58.52199936 Tm [(et)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 74.28900146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 78.78900146 58.52199936 Tm [(al.,)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 90.49199677 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 94.99199677 58.52199936 Tm [(20)-1(05)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 116.10299683 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 120.60299683 58.52199936 Tm [([PubMed)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 160.06599426 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 164.56599426 58.52199936 Tm [(16)-1(02)-1(46)-1(56]\).[supplied)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 254.83399963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 259.33401489 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 269.8460083 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(OMIM,)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 29.7329998 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 34.23300171 74.12200165 Tm [(Mar)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 51.43799973 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 55.93799973 74.12200165 Tm [(20)-1(08)-1(].)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 82.22200012 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 162 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 163 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 167 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 172 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 173 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WD)1(R6)-1(1)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 32.44499969 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 175 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 176 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 177 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(WD)1(R6)-1(1)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 148.79100037 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 187 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 190 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 191 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WD)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 16.01399994 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 20.51399994 11.72200012 Tm [(repeat)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 48.23899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 52.73899841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 85.56600189 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 90.06600189 11.72200012 Tm [(61)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 100.62200165 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 105.12200165 11.72200012 Tm [(\(WD)1(R6)-1(1\),)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 145.74499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 150.24499512 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 191.16700745 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 195.66700745 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 225.07099915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 229.57099915 11.72200012 Tm [(2)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 234.84899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 207 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 208 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 209 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(REC14;)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 29.56599998 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 34.06600189 11.72200012 Tm [(SKI8)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 52.89699936 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 213 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <</MCID 214 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 215 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9GZS3)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 35.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.8500061 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 217 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 16.47100067 19.52199936 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 20.97100067 19.52199936 Tm [(positive)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 56.80799866 19.52199936 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 61.30799866 19.52199936 Tm [(control:)] TJ ET EMC /P <</MCID 222 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 143.17500305 31.95000076 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 223 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(carc)-1(inoma)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 44.50799942 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 49.00799942 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 57.84999847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 62.34999847 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 92.39099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 96.89099884 11.72200012 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 125.35900116 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 129.85899353 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 154.59100342 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 159.09100342 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 175.36799622 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 179.86799622 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 209.90899658 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 214.40899658 11.72200012 Tm [(pro)1(sta)1(te)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 250.26800537 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 254.76800537 11.72200012 Tm [(tiss)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ue)-1(;)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 12.81900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 17.31900024 27.3220005 Tm [(carc)-1(inoma)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 61.82699966 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 66.32700348 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 75.16899872 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 79.66899872 27.3220005 Tm [(human)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 109.70999908 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 114.20999908 27.3220005 Tm [(pro)1(sta)1(te)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 150.06900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 154.56900024 27.3220005 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 179.30099487 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 78.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 79.5 m 142.80000305 95.09999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 95.84999847 m 142.80000305 111.44999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 112.19999695 m 142.80000305 127.79999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 128.54998779 m 142.80000305 144.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 144.8999939 m 142.80000305 160.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 161.25 m 142.80000305 176.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 177.6000061 m 142.80000305 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.2250061 m 422.42498779 177.2250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 423.17498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 124 0 R/Length 28620>>stream
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