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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 144.3710022 23.67700005 Tm 0 g [(CHRNA3)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 226.75300598 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 270.9289856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CHRNA)1(3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 101.64199829 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 122.64199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.89199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A0006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CHRNA)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.01699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.39099884 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.59300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<00070009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(LNCR2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.43399811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.80799866 12.82499981 Tm [(PA)1(OD)-1(2)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.66200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.03599548 12.82499981 Tm [(NA)1(CHRA3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.12800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000C000D000E000B0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<00100009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 47.37799835 l -0.75 47.37799835 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Synth)-1(e)1(ti)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.04399872 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.61500168 12.04500008 Tm [(pepti)-1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.83699799 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.40799713 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.19499969 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.76599884 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.5269928 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.0980072 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.40899658 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.97999573 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.37199402 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.94299316 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.62399292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.19500732 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.01499939 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.58599854 12.04500008 Tm [(69-83)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.58700562 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.15800476 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.19900513 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.76998901 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.20098877 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.77200317 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.26501465 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.83599854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.09298706 12.04500008 Tm [(cho)-1(li)-1(ner)1(gic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 377.95599365 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.52700806 12.04500008 Tm [(re)1(ceptor,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 29.98399925 Tm [(ni)-1(coti)-1(nic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.27099991 29.98399925 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.30599976 29.98399925 Tm [(alp)-1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.45100021 29.98399925 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.48600006 29.98399925 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.04800034 29.98399925 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.08300018 29.98399925 Tm [(\(n)-1(e)1(u)-1(r)1(o)-1(nal\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.46499634 29.98399925 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 46.37799835 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 46.37799835 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 46.62799835 m 426.3500061 46.62799835 l S Q Q q 1 0 0 1 0 320.51199341 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.45098877 m 416.75 348.45098877 l 416.75 379.65100098 l -1.45000005 379.65100098 l h f* Q q 1 0 0 1 0 348.45098877 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 109.77500153 0.75 l 109.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.77500153 -0.25 l 110.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 110.52500153 16.35000038 l h f* Q q 1 0 0 1 110.15000153 0 cm -0.625 -0.25 m 313.2749939 -0.25 l 313.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(choline)-1(rg)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.31999969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.81999969 11.72200012 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.40799713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.90799713 11.72200012 Tm [(nic)-1(ot)1(ini)-1(c,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.45199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.95199585 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.58599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.08599854 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.36399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.86399841 11.72200012 Tm [(\(ne)-1(uro)1(n)-1(a)1(l\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.147995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 109.77500153 0.75 l 109.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.77500153 -0.25 l 110.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 110.52500153 16.35000038 l h f* Q q 1 0 0 1 110.15000153 0 cm -0.625 -0.25 m 313.2749939 -0.25 l 313.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(LNCR2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.27599907 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.77600098 11.72200012 Tm [(PA)1(OD2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.24900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.74900055 11.72200012 Tm [(NACHRA)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.86599731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 109.77500153 0.75 l 109.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.77500153 -0.25 l 110.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 110.52500153 16.35000038 l h f* Q q 1 0 0 1 110.15000153 0 cm -0.625 -0.25 m 313.2749939 -0.25 l 313.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NP_00)-1(07)-1(34)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.52399826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 109.77500153 0.75 l 109.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 110.77500153 -0.25 l 110.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 110.52500153 16.35000038 l h f* Q q 1 0 0 1 110.15000153 0 cm -0.625 -0.25 m 313.2749939 -0.25 l 313.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P32)-1(29)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 109.77500153 0.75 l 109.77500153 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 110.77500153 -0.25 l 110.77500153 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 110.52500153 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 110.52500153 141.1499939 l h f* Q q 1 0 0 1 110.15000153 0 cm -0.625 -0.25 m 313.2749939 -0.25 l 313.2749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(locu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.10400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60400009 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.52100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.02100372 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.9960022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.4960022 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.75999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.25999451 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.102005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.602005 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.60299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.10299683 11.72200012 Tm [(nic)-1(ot)1(ini)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.48100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.98100281 11.72200012 Tm [(ace)-1(t)1(yl)-1(cho)1(l)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.30599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.80599976 11.72200012 Tm [(rec)-1(ept)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.74000168 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.24000168 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.08200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.58200073 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.22100067 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.72100067 27.3220005 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.51100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.01100159 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.85299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.35299683 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.80900574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.30900574 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.39100647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.89100647 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.73300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.23300171 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.70599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.20599365 27.3220005 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.91699219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.41699219 27.3220005 Tm [(pen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ta)1(me)-1(ric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2120018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.7120018 42.92200089 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.46299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.96299744 42.92200089 Tm [(comprised)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.24000549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.74000549 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.58200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.08200073 42.92200089 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44599915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.94599915 42.92200089 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08000183 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.35699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.85699463 42.92200089 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.03900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.53900146 42.92200089 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.17098999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.67098999 42.92200089 Tm [(Thi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 58.52199936 Tm [(locu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.00799942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.50799942 58.52199936 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.42500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.92500305 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.44599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.94599915 58.52199936 Tm [(alph)1(a-t)1(ype)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.44500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.94500732 58.52199936 Tm [(subunit,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.91099548 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.05200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.55200195 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.30000305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.80000305 58.52199936 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.01499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.51499939 58.52199936 Tm [(chara)1(c)-1(terist)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.18701172 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ad)1(jac)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.62799835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.12799835 74.12200165 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.07800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.57800293 74.12200165 Tm [(residues.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.4240036 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9240036 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.23100281 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.23800659 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.54499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.04499817 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.60600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.10600281 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.08099365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.58099365 74.12200165 Tm [(ligand)1(-ga)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.24700928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.74700928 74.12200165 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 89.72200012 Tm [(channe)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.39099884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.89099884 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.11299896 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.61299896 89.72200012 Tm [(lik)-1(ely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.56800079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.06800079 89.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.11499786 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.61500549 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.58999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.08999634 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.75 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.25 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.19099426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.69099426 89.72200012 Tm [(ne)-1(uro)1(transmissio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.51300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.01300049 89.72200012 Tm [(Polymorp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(hisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.70199966 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.20199966 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.14300156 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.64300156 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.09899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.59899902 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.11499786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.61499786 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.96199799 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.46199799 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.96899414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.46899414 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.59599304 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.09599304 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.49200439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.99200439 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.51300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.01300049 105.3219986 Tm [(inc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.01400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.51400757 105.3219986 Tm [(risk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.41101074 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.91101074 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.75299072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(smoking)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.91799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.41799927 120.92199707 Tm [(initiat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.49199677 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.99199677 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.26899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.76899719 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.29000092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.79000092 120.92199707 Tm [(inc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.79100037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.29100037 120.92199707 Tm [(susce)-1(pt)1(ibility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33399963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83399963 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.90899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.40899658 120.92199707 Tm [(lun)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.65301514 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.15301514 120.92199707 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.40899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.90899658 120.92199707 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(lternat)1(i)-1(v)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54899979 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.04899979 136.52200317 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.12999725 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.62999725 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.55200195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05200195 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.62199402 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.12199402 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.46899414 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.96899414 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.47599792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.97599792 136.52200317 Tm [(described.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.12799072 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 206.54998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.15000153 0.75 m 110.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.15000153 17.10000038 m 110.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.15000153 33.45000076 m 110.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.15000153 49.80000305 m 110.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 110.15000153 66.15000153 m 110.15000153 206.54998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 206.54998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.92498779 m 423.17498779 206.92498779 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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