%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 66 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 137.76400757 23.67700005 Tm 0 Tr [(VTI1A)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 197.51199341 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 307.95199585 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.95199585 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(VT)-1(I1)1(A)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.42700195 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.92700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.17700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(VTI1A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.84999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.22399902 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.9960022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.36999512 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.69099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.06500244 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.86099243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(MMDS)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.37000275 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.7440033 12.82499981 Tm [(MVti)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.73699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.11100006 12.82499981 Tm [(Vti)-1(1-r)1(p)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.83999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.21400452 12.82499981 Tm [(VT)-1(I1)1(RP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(VT)-1(I1)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.11699677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 142.42500305 156.75 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(V-SNAR)1(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.64699936 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.14699936 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.36899948 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.8690033 11.72200012 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.16100311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.66100311 11.72200012 Tm [(vesic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.56700134 11.72200012 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.30200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80200195 11.72200012 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.42900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.92900085 11.72200012 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.82598877 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(interactions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.50600052 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.00600052 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.40200043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.90200043 27.3220005 Tm [(t-)1(SNAREs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.98200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.48200226 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.75 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.25 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.25100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.75100708 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.73100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.23100281 27.3220005 Tm [(membrane.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.18200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.68200684 27.3220005 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.76199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(interactions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.50600052 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.00600052 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.52400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.02400208 42.92200089 Tm [(pro)1(posed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.42900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.92900085 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.0039978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.5039978 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.6289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.1289978 42.92200089 Tm [(asp)1(e)-1(cts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.15600586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.65600586 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.4980011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.9980011 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.99899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.49899292 42.92200089 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.85400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.35400009 58.52199936 Tm [(vesic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.75999832 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.25999832 58.52199936 Tm [(tr)1(aff)1(i)-1(cki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.76999664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.26999664 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.54699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.04699707 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.12199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.62199402 58.52199936 Tm [(pro)1(mote)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.14300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.64300537 58.52199936 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.13800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.63800049 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.47999573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.97999573 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.98100281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.48100281 58.52199936 Tm [(lipid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.17098999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(bilayers.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.15200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.65200043 74.12200165 Tm [(Involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.77200317 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.71299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.21299744 74.12200165 Tm [(vesic)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.47000122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.97000122 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.70500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.20500183 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.91600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.41600037 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.41700745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.91700745 74.12200165 Tm [(lat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.7460022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.2460022 74.12200165 Tm [(en)-1(d)1(os)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(omes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.42700005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.92700005 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.0019989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.5019989 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.50299835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.00299835 89.72200012 Tm [(tr)1(ans-Go)1(lgi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.33399963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.83399963 89.72200012 Tm [(ne)-1(t)1(wo)1(rk)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.16999817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.66999817 89.72200012 Tm [(Alo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.42199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.92199707 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.31799316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.81799316 89.72200012 Tm [(VAMP7,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.98100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.48100281 89.72200012 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.32500076 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82500076 105.3219986 Tm [(non-conven)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.07499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.57499695 105.3219986 Tm [(RA)1(B)-1(1-dependent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.6269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.1269989 105.3219986 Tm [(tr)1(aff)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03999329 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53999329 105.3219986 Tm [(rout)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.70399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.20401001 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.2789917 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9109993 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.4109993 120.92199707 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.27400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.77400208 120.92199707 Tm [(used)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.34899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84899902 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.36100006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.86100006 120.92199707 Tm [(KCNIP)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.34100342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.84100342 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.11799622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.61799622 120.92199707 Tm [(KCND)1(2)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.96800232 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.46800232 120.92199707 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.5 120.92199707 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.35400391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.85400391 120.92199707 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 136.52200317 Tm [(inc)-1(reased)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.80500031 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.30500031 136.52200317 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.60399628 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.10399628 136.52200317 Tm [(sec)-1(retio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.44799805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.94799805 136.52200317 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.07499695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.57499695 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.97099304 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.47099304 136.52200317 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.23300171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.73300171 136.52200317 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(en)-1(esce)-1(nce)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.87599945 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.1000061 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VT)-1(I)1(1)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.50099945 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 189.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(VT)-1(I)1(1)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.84700012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 157.5 m 142.05000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 173.8500061 m 142.05000305 189.45001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 190.20001221 m 142.05000305 205.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.80001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 173.4750061 m 422.42498779 173.4750061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.82501221 m 422.42498779 189.82501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.17501831 m 423.17498779 206.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>